Biology of circulating nucleic acids and possible roles in diagnosis and treatment in diabetes and cancer [0.03%]
循环核酸的生物学及其在糖尿病和癌症诊断与治疗中的潜在作用
Peter B Gahan
Peter B Gahan
The presence of DNA and RNA circulating in human plasma and serum is described. The possible sources of the DNA/RNA in blood, their ability to enter other cells and to express in the recipient cells are discussed and the relationship with m...
Adherence to anti-retroviral therapy and its determinants in HIV/AIDS patients: a review [0.03%]
艾滋病患者抗逆转录病毒治疗的依从性及其影响因素综述
Sahra Emamzadeh-Fard,Sahar E Fard,SeyedAhmad SeyedAlinaghi et al.
Sahra Emamzadeh-Fard et al.
Although Highly Active Anti-Retroviral Therapy (HAART) significantly reduced HIV/AIDS mortality, appropriate adherence level is recommended for viral suppression and therapeutic response in People Living with HIV/AIDS (PLWHA). In the most s...
Is Helicobacter pylori the infectious target to prevent gastric cancer? An interdisciplinary point of view [0.03%]
Hp：预防胃癌的感染目标吗？一种跨学科观点
Carmelo Luigiano,Francesco Ferrara,Sharmila Fagoonee et al.
Carmelo Luigiano et al.
Gastric carcinogenesis, which may well extend over decades, is characterized by a slow stepwise evolution from superficial gastritis to glandular atrophy, intestinal metaplasia, dysplasia, and finally, adenocarcinoma. This sequence provides...
Shooting at the DARC: potential issues with species-specific antimalarials [0.03%]
针对DARC的射击：物种特异性抗疟药潜在问题
I Woolley,K Horne
I Woolley
Scientific drug design enables the production of novel agents that may be specific for individual malaria species, particularly by targeting their methods of cellular entry. Though there are practical and theoretical barriers to introducing...
Chromium-picolinate therapy in diabetes care: individual outcomes require new guidelines and navigation by predictive diagnostics [0.03%]
糖尿病治疗中铬匹可隆疗法的个体化结局需要新的指南和预测性诊断导航
Kristina Yeghiazaryan,Hans H Schild,Olga Golubnitschaja
Kristina Yeghiazaryan
Aims: Nephropathy is the leading secondary complication of metabolic syndrome. Nutritional supplement by chromium-picolinate is assumed to have renoprotective effects. However, potential toxic effects reported increase th...
Antimicrobials targeted to the replication-specific DNA polymerases of gram-positive bacteria: target potential of dnaE [0.03%]
靶向革兰氏阳性菌复制特异性DNA聚合酶的抗菌药物：dnaE靶点潜力分析
Marjorie H Barnes,Michelle M Butler,George E Wright et al.
Marjorie H Barnes et al.
DNA polymerases pol IIIC and dnaE [i.e. pol IIIE] are essential for replicative DNA synthesis in low G:C Gram-positive eubacteria. Therefore, they have strong potential as targets for development of Gram-positive-selective antibacterial age...
Lacticin LC14, a new bacteriocin produced by Lactococcus lactis BMG6.14: isolation, purification and partial characterization [0.03%]
由乳酸链球菌BMG6.14产生的新型细菌素LC14的分离、纯化及部分性质研究
Samar Lasta,Hadda Ouzari,Nicolas Andreotti et al.
Samar Lasta et al.
A new bacteriocin, lacticin LC14, produced by Lactococcus lactis BMG6.14, was isolated and characterized. It was purified to homogeneity from overnight broth culture by ammonium sulfate precipitation, Sep-Pak chromatography, and two steps o...
Inflammatory mechanisms and redox status in periodontal and cardiometabolic diseases: effects of adjunctive nutritional antioxidants and statins [0.03%]
炎症机制和氧化还原状态在牙周疾病和心血管代谢性疾病中的作用：辅助使用营养抗氧化剂和他汀类药物的影响
Mena Soory
Mena Soory
Periodontal pathogens in plaque biofilm initiate periodontitis, which is influenced by genetic and environmental factors. The resultant pro-oxidant status imposed on the periodontium, exacerbated by episodic hyperinflammatory damage contrib...
Necrotizing acute pancreatitis current status - emerging new strategies in surgical management [0.03%]
急性坏死性胰腺炎的外科治疗新策略
George H Sakorafas,Dimitrios Sampanis,Christos Lappas et al.
George H Sakorafas et al.
Despite that pancreatic necrosis complicates only 15 % of cases of acute pancreatitis (AP), it is associated with high morbidity and considerable mortality. In an attempt to improve prognosis, many surgical strategies have been described du...