Pharmacokinetic and Pharmacodynamic Relationship of Blinatumomab in Patients with Non-Hodgkin Lymphoma [0.03%]
Blinatumomab在非霍奇金淋巴瘤患者中的药代动力学和药效学关系研究
Youssef Hijazi,Matthias Klinger,Andrea Kratzer et al.
Youssef Hijazi et al.
Background: Blinatumomab is a bispecific T-cell engager (BiTE®) antibody construct targeting CD3ε on T cells and CD19 on B cells. We describe the relationship between pharmacokinetics (PK) of blinatumomab and pharmacody...
Analysis of Toxicity Effects of Buspirone, Cetirizine and Olanzapine on Human Blood Lymphocytes: in Vitro Model [0.03%]
巴氯芬、西替利嗪和奥氮平对人外周血淋巴细胞毒性的分析：体外模型
Ahmad Salimi,Mosleh Razian,Jalal Pourahmad
Ahmad Salimi
Background: The current study investigates the cytotoxicity mechanism of common drugs with piperazine ring such as cetirizine, olanzapine and buspirone on human lymphocytes. ...
The Effect of Tranexamic Acid on Preventing Post-partum Hemorrhage Due to Uterine Atony: A Triple-blind Randomized Clinical Trial [0.03%]
氨甲环酸预防子宫乏力性产后出血的疗效研究：一项三盲随机临床试验
Mahvash Zargar,Roshan Nikbakht,Mahzad Ahmadi
Mahvash Zargar
Background: Postpartum haemorrhage (PPH) is an important cause of early maternal death which needs to be controlled. Objective: This st...
Bruno Mario Cesana,Elia Mario Biganzoli
Bruno Mario Cesana
Background: There is an increasing need to face regulatory aspects as well as ethics and scientific ones in the pharmaceutical research phase after the authorization of a drug. Traditionally, Phase IV studies, after the a...
The Benefit of Prescribing Vitamin D as Add on Therapy on the Electrocardiographic Changes in Epileptic Patients [0.03%]
维生素D作为附加疗法对癫痫患者心电图改变的影响研究
Marwan S Al-Nimer
Marwan S Al-Nimer
Background: Epileptic children and adolescent have a significantly low serum level of vitamin D due to the effect of antiepileptic drugs on the vitamin D metabolism. Those patients are at risk of cardiovascular events. ...
Targeting Brain Tumors with Nanomedicines: Overcoming Blood Brain Barrier Challenges [0.03%]
靶向脑肿瘤的纳米药物：克服血脑屏障挑战
Divya Khaitan,Polluru L Reddy,Nagendra Ningaraj
Divya Khaitan
Background: This review elucidates ongoing research, which show improved delivery of anticancer drugs alone and/ or enclosed in carriers collectively called nanomedicines to cross the BBB/ BTB to kill tumor cells and impa...
Fahad Aziz,Kunal Chaudhary
Fahad Aziz
Background: Lupus nephritis (LN) is a common complication in many patients with systemic lupus erythematosus, although renal-limited lupus nephritis has been reported as well. Early diagnosis of lupus nephritis is critica...
Claudio Daniel Gonzalez,Jorge Alvarinas,Ricardo Bolanos et al.
Claudio Daniel Gonzalez et al.
Background: The liver is the major metabolic clearance organ for chemical agents from the human body. Pregnancy is associated with several physiological changes that may affect one or more of these factors, and also induc...
Knowledge, Attitudes, and Practices of Pharmacovigilance and ADRs Spontaneous Reporting Among Pediatricians and Pediatric Residents in Jordan [0.03%]
约旦儿科医生和儿童住院医的药品警戒及不良反应自发报告的知识、态度与实践状况
Tareq L Mukattash,Maysaa W Alwadi,Rana K Abu-Farha et al.
Tareq L Mukattash et al.
Introduction: Pharmacovigilance (PV) is the science responsible for ADRs reporting and accordingly medication safety. Pediatrics age group is a special concern as they have a higher risk of developing ADRs; this put more ...