Metformin and Pregnancy Outcomes: Evidence Gaps and Unanswered Questions [0.03%]
二甲双胍与妊娠结局：有待解决的问题和未知领域
Claudio D Gonzalez,Jorge Alvariñas,Maria F G Bagnes et al.
Claudio D Gonzalez et al.
Background: Metformin is sometimes used as an alternative to insulin in gestational diabetes mellitus (GDM). It is also used to achieve ovulation in polycystic ovary syndrome (PCOS). Pre-natal exposure to metformin result...
The Possibility of Therapeutic Drug Monitoring of the Most Important Interactions in Nursing Homes [0.03%]
疗养院最重要的药物相互作用实行治疗药物监测的可能性
Pernille Schjøtt,Martina Šutovská,Jan Schjøtt
Pernille Schjøtt
Background: Therapeutic drug monitoring is a relevant tool in drug treatment of elderly patients. The aim of this study was to assess the possibility of therapeutic drug monitoring of the most important potential interact...
Protective Effect of Selenium-L-methionine on Radiation-induced Acute Pneumonitis and Lung Fibrosis in Rat [0.03%]
硒-左旋甲硫氨酸对放射致大鼠急性放射性肺炎和肺纤维化的保护作用研究
Peyman Amini,Sedighe Kolivand,Hana Saffar et al.
Peyman Amini et al.
Background: In this study, we aimed to detect the changes in the level of interleukin (IL)-4 and IL-13 cytokines and their downstream genes including interleukin-13 receptor subunit alpha-2 (IL13Ra2), interleukin-4 recept...
Role of Muscarinic Acetylcholine Receptors in Breast Cancer: Design of Metronomic Chemotherapy [0.03%]
胆碱能乙酰胆碱受体在乳腺癌中的作用：设计节律性化疗
María E Sales,Alejandro J Español,Agustina R Salem et al.
María E Sales et al.
Background: muscarinic acetylcholine receptors (mAChRs) have attracted interest as targets for therapeutic interventions in different illnesses like Alzheimer´s disease, viral infections and different tumors. Regarding t...
Pycnogenol Protects against Pentylenetetrazole-Induced Oxidative Stress and Seizures in Mice [0.03%]
吡咯烷二硫代氨基甲酸诱导的小鼠癫痫发作中的氧化应激损伤及法国松树皮提取物(Pycnogenol)的干预作用研究
Radha Goel,Prasoon Saxena
Radha Goel
Background: Epilepsy is one of the most common and severe brain disorders in the world, characterized by recurrent spontaneous seizures due to an imbalance between cerebral excitability and inhibition. Oxidative stress is...
Rabbit as an Animal Model for Pharmacokinetics Studies of Enteric Capsule Contains Recombinant Human Keratinocyte Growth Factor Loaded Chitosan Nanoparticles [0.03%]
口服壳聚糖纳米粒递送的重组人角化细胞生长因子药代动力学研究兔模型选择与建立
Palanirajan V Kumar,Marwan A Abdelkarim Maki,Yeong S Wei et al.
Palanirajan V Kumar et al.
Background: Recombinant human keratinocyte growth factor (rHuKGF) has gained considerable attention by researchers as epithelial cells proliferating agent. Moreover, intravenous truncated rHuKGF (palifermin) has been appr...
The Ascent of Mineralocorticoid Receptor Antagonists in Diabetic Nephropathy [0.03%]
盐皮质激素受体拮抗剂在糖尿病肾病中地位的提升
Luxitaa Goenka,Raghavan Padmanaban,Melvin George
Luxitaa Goenka
Diabetic nephropathy is defined as a decline in the renal function and an increase in the amount of albuminuria (>300 mg/day). The interruption of the renin-angiotensin-aldosterone system (RAAS) by well-established therapies such as angiote...
The Cytotoxicity and Synergistic Potential of Aspirin and Aspirin Analogues Towards Oesophageal and Colorectal Cancer [0.03%]
关于阿司匹林及其衍生物对食道癌和结直肠癌细胞毒性和协同作用的体外研究
Rajagopal S Kilari,Asma&#x;u I J Bashir,Andreue Devitt et al.
Rajagopal S Kilari et al.
Background: Oesophageal cancer (OC) is a deadly cancer because of its aggressive nature with survival rates that have barely improved in decades. Epidemiologic studies have shown that low-dose daily intake of aspirin can ...
Multiple Drug Intolerance Syndrome: An Underreported Distinct Clinical Entity [0.03%]
多重药物耐受综合症：一种被低估的独立临床实体
Sapan K Behera,Saibal Das,Kavadichanda G Chengappa et al.
Sapan K Behera et al.
Aim: Multiple drug intolerance syndrome (MDIS) is a unique clinical entity distinct from other drug hypersensitivity syndromes. The aim of this review was to critically appraise the various aspects of MDIS. ...
Desensitization of 5-HT-1A Somatodentritic Receptors in Tryptophan Treated and Co-treated Rats Induced by Methylphenidate [0.03%]
甲基苯丙胺诱导色氨酸喂养及联合给药大鼠5-ht-1a胞体树突突触脱敏化
Muhammad Farhan,Fatima Riaz,Sana Wali et al.
Muhammad Farhan et al.
Background: Psychostimulants can induce behavioral sensitization by their chronic use. The main target for the action of these drugs is dopamine, neither epinephrine nor serotonin transporters. Serotonin is synthesized by...