A review of clinical pharmacokinetics and pharmacodynamics of galantamine, a reversible acetylcholinesterase inhibitor for the treatment of Alzheimer's disease, in healthy subjects and patients [0.03%]
一项关于可逆性乙酰胆碱酯酶抑制剂石南花低托品在健康受试者和病人中用于治疗阿尔茨海默病的临床药动学及药效学评价的综述文章
Fenglei Huang,Yali Fu
Fenglei Huang
Galantamine is a reversible acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. Following oral administration, galantamine is rapidly absorbed and reaches C(max) in approximately one hour for immediate release (IR) tabl...
Ronald W Pero
Ronald W Pero
Hippuric acid has been a major human metabolite for years. However, there is no well-known documented health benefit associated with it except for excretion of environmental-toxic exposures of aromatic compounds such as toluene, or from die...
Daniela Ilieva Batovska,Iva Todorova Todorova
Daniela Ilieva Batovska
Chalcones (1,3-diaryl-2-propen-1-ones) are open chain flavonoids that are widely biosynthesized in plants. They are important for the pigmentation of flowers and, hence, act as attractants to the pollinators. As flavonoids, chalcones also p...
Antje Wolf,Mohammad Shahid,Vinod Kasam et al.
Antje Wolf et al.
The first step in finding a "drug" is screening chemical compound databases against a protein target. In silico approaches like virtual screening by molecular docking are well established in modern drug discovery. As molecular databases of ...
Is there a place for drug combination strategies using clinical pharmacology attributes?--review of current trends in research [0.03%]
临床药理特征的联合用药策略展望—目前研究趋势综述
Nuggehally R Srinivas
Nuggehally R Srinivas
Drug discovery is the main flag ship of the pharmaceutical industry in order to ensure that innovations constantly occur in the identification and development of novel therapeutic options for the management of diseases. Recently, research t...
Zuzana Adamova,Sifa Ozkan,Raouf A Khalil
Zuzana Adamova
Normal pregnancy is associated with significant hemodynamic changes in the cardiovascular system in order to meet the metabolic demands of mother and fetus. These changes include increased cardiac output, decreased vascular resistance, and ...
Gender differences in aminoglycoside induced nephrotoxicity: a prospective, hospital-based study [0.03%]
氨基糖苷类致肾毒性的性别差异：一项基于医院的前瞻性研究
Waleed M Sweileh
Waleed M Sweileh
Aim: Impact of gender on aminoglycoside induced nephrotoxicity is still controversial and inconclusive. The objective of this study was to investigate the nephrotoxic potential of amikacin (AK) and gentamicin (GM) in male...
Comparative Study
Current clinical pharmacology. 2009 Sep;4(3):229-32. DOI:10.2174/157488409789375339 2009
Identifying the metabolic syndrome in obese children and adolescents: do age and definition matter? [0.03%]
在肥胖儿童和青少年中诊断代谢综合征：年龄和定义重要吗？
Mariska van Vliet,Inès A von Rosenstiel,Roger K Schindhelm et al.
Mariska van Vliet et al.
Objectives: To assess the prevalence of the metabolic syndrome (MetS) in overweight/obese children and adolescents of an out-patient clinic, and to compare two definitions of MetS in adolescents. ...
Comparative Study
Current clinical pharmacology. 2009 Sep;4(3):233-8. DOI:10.2174/157488409789375276 2009
Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity [0.03%]
适应性草药改善疲劳的循证疗效及其压力保护活性的相关分子机制
Alexander Panossian,Georg Wikman
Alexander Panossian
The aim of this review article is to assess the level of scientific evidence presented by clinical trials of adaptogens in fatigue, and to provide a rationale at the molecular level for verified effects. Strong scientific evidence is availa...
Molecular determinants of fluoroquinolone antibacterial agents pharmacokinetics [0.03%]
氟喹诺酮类抗菌药物药动学的分子决定因素
Dominique Levêque,François Jehl
Dominique Levêque
This review presents the published data regarding the molecular determinants (enzymes, transporters, orphan nuclear receptors) of fluoroquinolones pharmacokinetics in humans. The clinical impact of these determinants (drug disposition, drug...