Emma J Woodward,Chris Twelves
Emma J Woodward
The taxanes are widely used in the cytotoxic treatment of many solid tumours. Their optimal scheduling, however, remains unconfirmed. Here we review the development of both paclitaxel and docetaxel to identify evidence influencing the choic...
Lianet Monzote,Lars Gille
Lianet Monzote
Diseases caused by parasitic infections are responsible for considerable morbidity and mortality. The progress in the development of vaccines against parasite infections tends to be slow and the epidemiological control of diseases is unsati...
Antibiotics in endophthalmitis: microbiological and pharmacokinetic considerations [0.03%]
玻璃体炎的抗生素治疗：微生物及药动学因素的影响
Carmen López-Cabezas,Dolors Soy Muner,Merce Roca Massa et al.
Carmen López-Cabezas et al.
Ocular infections must be treated with active antibiotics which could be administered by different routes: topical, systemic or intravitreal. In the case of endophthalmitis, the most important factor to avoid permanent damage of retina is a...
Hyperhomocysteinemia and cardiovascular risk: effect of vitamin supplementation in risk reduction [0.03%]
同型半胱氨酸与心血管风险：维生素补充剂的干预作用
Marcello Ciaccio,Chiara Bellia
Marcello Ciaccio
Homocysteine is a sulfur-containing aminoacid produced during metabolism of methionine. Since 1969 the relationship between altered homocysteine metabolism and both coronary and peripheral atherotrombosis has been known; in recent years exp...
Clinical pharmacology and lesion penetrating properties of second- and third-line antituberculous agents used in the management of multidrug-resistant (MDR) and extensively-drug resistant (XDR) tuberculosis [0.03%]
临床药物研究和二线及三线抗结核病药治疗多耐药（MDR）和广泛耐药（XDR）肺结核的病灶穿透属性
Véronique Dartois,Clifton E Barry
Véronique Dartois
Failure of first-line chemotherapy to cure tuberculosis (TB) patients occurs, in part, because of the development of resistance to isoniazid (INH) and rifampicin (RIF) the two most sterilizing agents in the four-drug regimen used to treat p...
Hepatitis C virus infection and antiviral treatment in marginal zone lymphomas [0.03%]
边缘区淋巴瘤患者中的丙型肝炎病毒感染及抗病毒治疗
Luca Arcaini,Raffaele Bruno
Luca Arcaini
The association between hepatitis C virus (HCV) infection and B-cell non-Hodgkin's lymphomas has been demonstrated in epidemiological studies, in particular in highly endemic geographical areas such as Italy, Japan and southern parts of Uni...
The treatment of cardiovascular disease continuum: focus on prevention and RAS blockade [0.03%]
心血管疾病连续体的治疗：侧重于预防和肾素血管紧张素系统阻断疗法
Steven G Chrysant,George S Chrysant,Catherine Chrysant et al.
Steven G Chrysant et al.
The cardiovascular disease continuum is a sequence of events, which begins with a host of risk factors consisting of diabetes mellitus, dyslipidemia, hypertension, smoking and visceral obesity. If left untreated, it will inexorably progress...
Pretreatment by hyperoxia--a tool to reduce ischaemia-reperfusion injury in the myocardium [0.03%]
高压氧预处理可减少心肌缺血再灌注损伤
Inga Karu,Peeter Tähepõld,Arno Ruusalepp et al.
Inga Karu et al.
Atherosclerosis leads to narrowing and occlusion of coronary arteries, resulting in inadequate oxygen supply for maintenance of normal oxidative metabolism. To avoid profound ischaemia and subsequent necrosis of cardiomyocytes, blood flow h...
Kei Nakajima
Kei Nakajima
People with metabolic syndrome (MetS) are at increased risk of type 2 diabetes and cardiovascular diseases, and often have increased triglyceride, reduced high-density lipoprotein cholesterol (HDL-C) and sometimes moderately increased low-d...
Kunal Chaudhary,Shadi Haddadin,Ravi Nistala et al.
Kunal Chaudhary et al.
The peritoneum is a cavity which has been successfully utilized by nephrologists to perform peritoneal dialysis (PD) in patients with renal failure. The physiologic characteristic of the peritoneal cavity not only helps remove toxic metabol...