From treatment adherence to advanced shared decision making: new professional strategies and attitudes in mental health care [0.03%]
从治疗依从性到先进共决制定策：精神健康照护中的新专业策略和态度
Giuseppe Tibaldi,Luis Salvador-Carulla,Juan Carlos García-Gutierrez
Giuseppe Tibaldi
Treatment adherence is related to "self-regulation" of prescribed drugs. Patients organise their drug intake around their own priorities, which may be very different from prescribers' priorities, since most of the patients value their perso...
Tissue protective and anti-fibrotic actions of suramin: new uses of an old drug [0.03%]
磺达肝葵钠的组织保护和抗纤维化作用：老药新用
Na Liu,Shougang Zhuang
Na Liu
Suramin is a polysulfonated naphthylurea, which was originally synthesized and designed as a treatment for trypanosomiasis and selected malignancies and metastatic diseases. Increasing evidence indicates that suramin is also effective in in...
Looking beyond inhibition of VEGF/mTOR: emerging targets for renal cell carcinoma drug development [0.03%]
从VEGF/mTOR抑制作用着眼：肾细胞癌药物研发的新靶点初探
Neal Rasmussen,W Kimryn Rathmell
Neal Rasmussen
The incidence rates of renal cell carcinoma (RCC) have continued to rise with 58,000 new cases in the United States. RCC has notoriously been refractory to traditional chemotherapeutic including radiation and cytokine therapies. The advent ...
Christoph Metalidis,Dirk R J Kuypers
Christoph Metalidis
Calcineurin inhibitors (CNI), a cornerstone of current immunosuppressive therapy, have important cardiovascular and oncogenic side effects and CNI nephrotoxicity contributes to the multifactorial process called "chronic allograft dysfunctio...
Francesco Azzaroli,Laura Turco,Andrea Lisotti et al.
Francesco Azzaroli et al.
Intrahepatic cholestasis of pregnancy is the most common liver disease occurring in the second half of pregnancy, characterized by pruritus and elevated serum bile acids often coupled to abnormal liver tests. Maternal prognosis is favourabl...
A comprehensive literature search: drugs as possible triggers of Takotsubo cardiomyopathy [0.03%]
全面文献检索：药物诱发应激性心肌病的证据
Pedro Amariles
Pedro Amariles
Background: Takotsubo cardiomyopathy (TCM) is a syndrome of transient cardiac dysfunction precipitated by intense emotional or physical stress. Excessive sympathetic stimulation is believed to be central to the pathogenes...
Tigecycline treatment of critically ill patients: the LatinUser experience [0.03%]
重症患者替加环素治疗的拉丁用户体验
Daniel Curcio,Sandra Whittle Vargas,Sebastián Ugarte Ubiergo et al.
Daniel Curcio et al.
Tigecycline is the first of a new class of antibiotics named glycylcyclines and it was approved for the treatment of complicated intra-abdominal infections and skin and skin structure infections and community-acquired bacterial pneumonia. N...
Comparative bioavailability study of a new formulation of injection of 75 mg diclofenac sodium in 1 ml with the conventional injection of 75 mg diclofenac sodium given in 3 ml volume [0.03%]
75毫克硫酸舒林酸注射液新剂型与常规75毫克硫酸舒林酸3毫升体积规格的注射液生物等效性研究
Dhaneshwar Shep,Ashwini Ojha,Sweta Patel et al.
Dhaneshwar Shep et al.
Objectives: Diclofenac a non-steroidal anti-inflammatory drug (NSAID) is widely used for the management of various musculoskeletal conditions. An injectable test formulation of diclofenac sodium (75 mg/mL) was prepared to...
Randomized Controlled Trial
Current clinical pharmacology. 2011 Feb;6(1):26-9. DOI:10.2174/157488411794941359 2011
Pharmacodynamic biomarkers in model-based drug development in oncology [0.03%]
基于模型的肿瘤药物研发中的药效学生物标志物
Ron J Keizer,Jan H M Schellens,Jos H Beijnen et al.
Ron J Keizer et al.
Introduction: Model-based drug development (MBDD) is recognized as an initiative able to improve success rates in the development of new anti-cancer agents. The use of pharmacodynamic (PD) biomarkers may be valuable in th...
Bronchodilator combination therapy for the treatment of chronic obstructive pulmonary disease [0.03%]
慢性阻塞性肺疾病的支气管扩张剂联合疗法
Sanjay Sethi,Claudia Cote
Sanjay Sethi
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality, and its prevalence is rising worldwide. Bronchodilators remain the cornerstone of COPD treatment, especially inhaled β2-adrenergic receptor agonists ...