Antithrombotic Therapy in Patients with Complex Percutaneous Coronary Intervention and Cardiogenic Shock [0.03%]
复杂经皮冠状动脉介入治疗合并心脏源性休克患者的抗栓治疗
Jose Ignacio Larrubia Valle,Cristóbal A Urbano-Carrillo,Francesco Costa
Jose Ignacio Larrubia Valle
Managing antithrombotic therapy in patients undergoing complex and high-risk in indicated patients, including those treated with complex percutaneous coronary intervention (PCI) or presenting with cardiogenic shock (CS), is challenging. Thi...
Riccardo Rinaldi,Andrea Ruberti,Salvatore Brugaletta
Riccardo Rinaldi
Early mechanical reperfusion, primarily via percutaneous coronary intervention, combined with timely antithrombotic drug administration, constitutes the main approach for managing acute coronary syndrome (ACS). Clinicians have access to a v...
Placido Maria Mazzone,Marco Spagnolo,Davide Capodanno
Placido Maria Mazzone
The antithrombotic management of chronic coronary syndrome (CCS) involves a 6-month course of dual antiplatelet therapy (DAPT), followed by chronic aspirin therapy. In patients with a baseline indication for anticoagulation, a variable dura...
High Bleeding Risk in Patients Undergoing Coronary and Structural Heart Interventions [0.03%]
冠脉和结构性心脏介入手术患者的高出血风险
Mattia Galli,Domenico D&#x;Amario
Mattia Galli
Percutaneous coronary and structural heart interventions are increasingly preferred over cardiac surgery due to reduced rates of periprocedural complications and faster recovery but often require postprocedural antithrombotic therapy for th...
Genetic Determinants of Response to P2Y12 Inhibitors and Clinical Implications [0.03%]
P2Y12抑制剂反应的遗传决定因素及其临床意义
Larisa H Cavallari,James C Coons
Larisa H Cavallari
The CYP2C19 enzyme metabolizes clopidogrel, a prodrug, to its active form. Approximately 30% of individuals inherit a loss-of-function (LoF) polymorphism in the CYP2C19 gene, leading to reduced formation of the active clopidogrel metabolite...
Regulation of Platelet Activation and Coagulation: Current Concepts, Novel Targets, and Therapies [0.03%]
血小板活化和凝血的调控：当前概念、新靶点及疗法
Tobias Harm,Karin Anne Lydia Mueller,Tobias Geisler
Tobias Harm
Antiplatelet and anticoagulant therapies are cornerstones of secondary prevention in high-risk cardiovascular patients. Whereas in former days the focus was set on effective antithrombotic effects, more recent trials and guidelines placed e...
Pathogenesis, Diagnosis, and Management of Chronic Thromboembolic Pulmonary Hypertension [0.03%]
慢性血栓性肺动脉高压的发病机制、诊断和治疗
Malika Elhage Hassan,Jorge Vinales,Sidney Perkins et al.
Malika Elhage Hassan et al.
Chronic thromboembolic pulmonary hypertension (CTEPH) is thought to occur as a sequelae of thromboembolic processes in the pulmonary vasculature. The pathophysiology of CTEPH is multifactorial, including impaired fibrinolysis, endothelial d...
Known Unknowns in the Contemporary Management of High-Risk Pulmonary Embolism: What Do the Guidelines Tell Us [0.03%]
高危肺栓塞当代治疗中的已知未知问题——指南述评
Chaitra Janga,Anand Reddy Maligireddy,Vikas Aggarwal et al.
Chaitra Janga et al.
Pulmonary embolism (PE) is a life-threatening condition with increasing hospital admissions. Prompt identification and treatment of PE patients with hemodynamic collapse are essential. Conflicting recommendations and weak evidence hinder ef...
Amine Nasri,Riyaz Bashir,Vladimir Lakhter
Amine Nasri
Since the publication of the first case series reporting the outcomes of patients with chronic thromboembolic pulmonary hypertension who underwent treatment with balloon pulmonary angioplasty more than 30 years ago, significant improvements...
Novel Risk Stratification and Hemodynamic Profiling in Acute Pulmonary Embolism: A Proposed Classification Inspired by Society for Cardiovascular Angiography and Intervention Shock Staging [0.03%]
急性肺栓塞新型风险分层及血流动力学分类 profiling急诊心血管介入医师学会休克分期的启示
Sonali Arora,Saraschandra Vallabhajosyula,Vikas Aggarwal et al.
Sonali Arora et al.
Treatment options for patients with acute pulmonary embolism (PE) and right ventricular shock (RVS) have grown exponentially. Therapy options include anticoagulation, systemic thrombolysis, catheter-based thrombolysis/ thrombectomy, and may...