Nanocrystalization: An Emerging Technology to Enhance the Bioavailability of Poorly Soluble Drugs [0.03%]
纳米结晶技术提高药物溶解度和生物利用度的研究进展与发展机遇展望
Kavita Joshi,Akhilesh Chandra,Keerti Jain et al.
Kavita Joshi et al.
Most of the active pharmaceutical ingredient used in the management of disease have poor water solubility and offer grueling problems in drug formulation development since low solubility is generally associated with poor dissolution charact...
The Scalability of Wet Ball Milling for The Production of Nanosuspensions [0.03%]
纳米悬浮液生产过程中湿式球磨的可扩展性研究
Maria L A D Lestari,Rainer H Müller,Jan P Möschwitzer
Maria L A D Lestari
Background: Miniaturization of nanosuspensions preparation is a necessity in order to enable proper formulation screening before nanosizing can be performed on a large scale. Ideally, the information generated at small sc...
Systematic Development of Sertraline Loaded Solid Lipid Nanoparticle (SLN) by Emulsification-Ultrasonication Method and Pharmacokinetic Study in Sprague-Dawley Rats [0.03%]
载舒必利固脂体纳米粒的系统制备及在Sprague Dawley大鼠中的药动学研究
Mohammad A Rahman,Ranjit K Harwansh,Zeenat Iqbal
Mohammad A Rahman
Objective: To circumvent the aforementioned problems and for the successful delivery of those newly discovered poorly soluble compounds, researchers have focused on the feasibility of biocompatible lipids such as Solid li...
Reza Baradaran Eftekhari,Niloufar Maghsoudnia,Shabnam Samimi et al.
Reza Baradaran Eftekhari et al.
Massive data available on cancer therapy more than ever lead our mind to the general concept that there is no perfect treatment for cancer. Indeed, the biological complexity of this disease is too excessive to be treated by a single therape...
Fatemah Bahman,Khaled Greish,Sebastien Taurin
Fatemah Bahman
Diabetes is a group of diseases characterized by hyperglycemia and originating from the deficiency or resistance to insulin, or both. Ultimately, the most effective treatment for patients with diabetes involves subcutaneous injections of in...
Functional Nanomaterials and Their Potential Applications in Antibacterial Therapy [0.03%]
功能性纳米材料及其在抗菌治疗中的潜在应用
Le Hong,Shu-Han Luo,Chen-Hao Yu et al.
Le Hong et al.
In the past decades, nanomaterials have shown great potential in biomedical fields, especially in drug delivery, imaging and targeted therapy. Recently, the development of novel functional nanomaterials for antibacterial application has att...
Preparation, Optimization and In vitro Evaluation of Glipizide Nanoparticles Integrated with Eudragit RS-100 [0.03%]
与Eudragit RS-100共沉淀的格列吡嗪纳米颗粒的制备、优化及体外评价研究
P Saharan,K Bahmani,S P Saharan
P Saharan
Background: Solubility is an important criterion for drug efficacy, independent of the route of administration. It also poses a major challenge for pharmaceutical industries, which are developing new pharmaceutical produc...
Unusual Enthalpy Driven Self Assembly at Room Temperature with Chitosan Amphiphiles [0.03%]
室温下壳聚糖两亲剂的焓驱动自组装现象
Uchechukwu Odunze,Fionn O&#x;Brien,Lisa Godfrey et al.
Uchechukwu Odunze et al.
Background: GCPQ (N-palmitoyl-N-monomethyl-N,N-dimethyl-N,N,N-trimethyl- 6-O-glycolchitosan) is a self-assembling polymer being investigated as a pharmaceutical nano-carrier. GCPQ nanoparticles shuttle drugs across biolog...
Ijeoma Uchegbu
Ijeoma Uchegbu
Enhanced Water Dispersibility of Curcumin Encapsulated in Alginate-Polysorbate 80 Nano Particles and Bioavailability in Healthy Human Volunteers [0.03%]
包裹姜黄素的海藻酸-吐温80纳米颗粒的增强亲水性和健康志愿者中的生物利用度研究
Roopa Govindaraju,Roopa Karki,Jayanthi Chandrashekarappa et al.
Roopa Govindaraju et al.
Background: The turmeric (Curcuma longa) plant, a perennial herb of the ginger family, is an agronomic crop in the south and southeast tropical Asia. Turmeric an Indian yellow gold and universal spice is described in Ayur...