Upper limb rehabilitation in multiple sclerosis: A retrospective analysis of nine hole peg test and box and block test responses across disability levels and disease courses [0.03%]
多发性硬化上肢康复的回顾性分析：九孔插钉测试和盒子与积木测试在不同残疾等级和疾病病程中的反应
Rita Bertoni,Albino Spedicato,Matteo Meotti et al.
Rita Bertoni et al.
Background: Early impairments in Multiple Sclerosis, such as reduced hand dexterity, worsen as disability progresses. Rehabilitation is essential, yet evidence on the efficacy of upper limb (UL) interventions remains limi...
Retinal neuroaxonal degeneration in NMOSD vs. MS and unaffected controls: A systematic review and meta-analysis of OCT biomarkers [0.03%]
NMOSD和多发性硬化症以及健康对照者的眼科相干层析成像生物标志物系统评价和meta分析：视网膜神经轴索损伤的对比研究
Bojun Wang,Jiayue Liu,Huiyuan Zhang et al.
Bojun Wang et al.
Background: Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease characterized by optic neuritis and myelitis, often misdiagnosed as multiple sclerosis (MS). Optical coherence tomography (OCT) provides ...
A case-control study of the oral microbiome among Australian female adults with relapsing-remitting multiple sclerosis: A pilot study [0.03%]
澳大利亚复发缓解型多发性硬化症成人女性口腔微生物组的病例对照研究：一项试点研究
Olivia C Wills,Xin-Yi Chua,Conor McEvoy et al.
Olivia C Wills et al.
Background: There is growing evidence investigating the role of the gut microbiome in the onset and progression of multiple sclerosis (MS). However, the role of the oral microbiome in MS is poorly understood, despite its ...
Vasoactive intestinal Peptide as a diagnostic or prognostic biomarker in multiple sclerosis: A systematic review [0.03%]
血管活性肠肽可作为多发性硬化症的诊断或预后生物标志物吗：系统综述研究
Alicia Cabrera-Martín,Yasmina Juarranz,Irene Gutiérrez-Cañas et al.
Alicia Cabrera-Martín et al.
Background: Biomarkers are crucial in multiple sclerosis (MS) to improve diagnosis, prognosis, and disease monitoring in this heterogeneous immune-mediated disorder. Vasoactive intestinal peptide (VIP) is an immunomodulat...
Discontinuing immunotherapy in aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorder: Relapse risk and disability outcomes after treatment withdrawal [0.03%]
抗水通道蛋白-4免疫球蛋白阳性神经脊髓炎谱系障碍患者停止使用免疫疗法后的复发风险和停药后果
Natapong Thaneerat,Jirud Buranaattachai,Chatdaw Lapngampian et al.
Natapong Thaneerat et al.
Background: Aquaporin-4-immunoglobulin G-seropositive neuromyelitis optica spectrum disorder (AQP4-IgG+ NMOSD) is a relapse-associated inflammatory disease in which attacks drive irreversible disability. Treatment discont...
Overweight and obesity: A second functional burden that amplifies gait vulnerability in early multiple sclerosis [0.03%]
体重超重和肥胖对早期多发性硬化症步态脆弱性的放大作用
David Péron,Sébastien Leteneur,Béatrice Degraeve et al.
David Péron et al.
Background: Overweight and obesity (OW/OB) are prevalent in patients with multiple sclerosis (PwMS) from disease onset and are associated with faster disease progression. While gait impairment is one of the most disabling...
Evidence of musculoskeletal pain sensitization in patients with multiple sclerosis: Case-control study [0.03%]
多发性硬化患者肌肉骨骼疼痛敏感化的证据：病例对照研究
Abdullah Alqarni,Areej Khan,Awatef Aljohani et al.
Abdullah Alqarni et al.
Background: Chronic musculoskeletal pain is a common symptom in individuals with multiple sclerosis (MS), however the underlying pain mechanisms remain complex and not fully understood. Therefore, this study aims to inves...
Spatially heterogeneous T1w/T2w ratio alterations in relapsing-remitting multiple sclerosis: associations with cognitive impairment [0.03%]
复发缓解型多发性硬化患者的T1w / T2w空间异质性比率变化与认知障碍的关系
Xiaoshuang Ru,Xuesong Li,Shilong Zhao et al.
Xiaoshuang Ru et al.
Objective: The T1w/T2w ratio has been proposed as a feasible MRI biomarker reflecting tissue microstructural integrity. This study investigated its alterations across brain tissue types and regions in relapsing-remitting ...
DIscontinuation of disease-modifying therapies in older adults with multiple sclerosis [0.03%]
多发性硬化症老年患者的疾病修正治疗停药问题
Jieni Li,George J Hutton,Rajender R Aparasu
Jieni Li
Background: Disease-modifying therapy (DMT) use in older adults with multiple sclerosis (MS) is debated due to age-related factors, effectiveness, and economic concerns of DMTs. Therefore, this study examined the factors ...
Urinary tract infections, urosepsis, and multiple sclerosis disease modifying therapies: a disproportionality analysis of the FDA Adverse Event Reporting System [0.03%]
基于FDA不良事件报告系统的泌尿系统感染和败血症与多发性硬化治疗药物的关联分析
Alexandra Balshi,Madelyn Esser,Tamara B Kaplan
Alexandra Balshi
Infection-related complications, including urinary tract infections (UTIs) and urosepsis, account for a significant proportion of morbidity and mortality in patients with advanced multiple sclerosis (MS). However, the role of specific disea...