PP023. Soluble Fms-like tyrosine kinase-1 and placental growth factor expression in a rat model of pre-eclampsia [0.03%]
溶血性胎盘生长因子在子痫前期大鼠模型中的表达研究
Lei Liu,Huishu Liu,Shaun Brennecke et al.
Lei Liu et al.
Background/aims: Soluble Fms-like tyrosine kinase-1(sFlt-1) and placental growth factor (PIGF) have been used clinically to predict preeclampsia (PE). This study investigated these factors in a rat model of preeclampsia i...
Lei Liu,Huishu Liu,Qian Huang et al.
Lei Liu et al.
Background/aims: Eclampsia, a leading cause of maternal mortality. Little is known about the causes of eclampsia and there is no effective treatment. Development of an animal model may help to expand our understanding and...
PP019. A new player in preeclampsia: The NF-E2-related factor 2 (NRF2) [0.03%]
子痫前期的新星球员：NF-E2相关因子2(NRF2)
Nisreen Kweider,Berthold Huppertz,Ulrich Pecks et al.
Nisreen Kweider et al.
Introduction: Preeclampsia PE is characterized by diminished antioxidant capacity. These enzymes are mainly regulated via the transcription factor Nrf2. O...
PP018. Does altitude affect the placental renin angiotensin system (RAS) in pre-eclampsia (PE)? [0.03%]
高原地区子痫前期患者胎盘肾素血管紧张素系统的改变及其临床意义
Lesia Kurlak,Hiten Mistry,Tereza Cindrova-Davies et al.
Lesia Kurlak et al.
Introduction: We have previously shown the activation of placental RAS in high altitude normotensive (NT) pregnancies [1], presumably related to hypoxia during placental development. PE incidence is increased at high alti...
PP021. The role of the transcription factor Nrf2 in the murine placental development [0.03%]
转录因子Nrf2在小鼠胎盘发育中的作用
Nisreen Kweider,Jenny Kistermann,Christoph Jan Wruck et al.
Nisreen Kweider et al.
Introduction: The placenta is the key organ for successful pregnancy and fetal growth. Oxidative stress during early human placental development is associated with pregnancy-related disorders. The transcription of many an...
Nisreen Kweider,Christoph Jan Wruck,Andreas Ludwig et al.
Nisreen Kweider et al.
Introduction: Smoking during pregnancy is associated with lower preeclampsia risk. This has been mainly explained through the effect of carbon monoxide CO. ...
PP015. Plasma levels and placental expression of BNP/NT-proBNP in early and late onset preeclampsia [0.03%]
早期和晚期子痫前期患者血浆利钠肽及胎盘BNP/NT-proBNP表达水平分析
Junus Katja,Wikström Anna-Karin,Larsson Anders et al.
Junus Katja et al.
Introduction: Women with preeclampsia (PE) have elevated plasma levels of NT-proBNP. We hypothesized that the placenta may be a source to these elevated levels. ...
PP016. Relation of apoptosis, proliferation and angiogenesis in early and late onset of preeclampsia [0.03%]
早期和晚期子痫前期发生的凋亡、增殖及血管生成的关系研究
Zulfiya Khodzhaeva,Eugenia Kogan,Alexey Kholin et al.
Zulfiya Khodzhaeva et al.
Introduction: The placental bed plays a key role in placentation during gestation. Most studies investigated the expression of angiogenic factors in the placenta, but their expression and potential role in the placental b...
PP013. Single nucleotide polymorphisms of the maternal cystathionine-b-synthase gene are associated with preeclampsia (PE) [0.03%]
母体胱硫醚-β-合成酶基因单核苷酸多态性与子痫前期(PE)相关
Kim Holwerda,Susanne Weedon-Fekjær,Annetine Staff et al.
Kim Holwerda et al.
Introduction: Cystathionine-b-synthase (CBS) produces the vasodilatory and anti-inflammatory hydrogen sulfide (H2S) by conversion of homocysteine (Hcy). H2S is involved in placental vascular tone regulation. Previously, w...