Development and Verification of a novel cuproptosis- and immune-associated based prognostic genetic signature for pancreatic ductal adenocarcinoma [0.03%]
一种新型杯状细胞凋亡和免疫相关基因预后特征在胰腺导管腺癌中的研发与验证
Xiang Xu,Jia-Hua Liang,Qiong-Cong Xu et al.
Xiang Xu et al.
Objective: Pancreatic ductal adenocarcinoma (PDAC) is a malignancy with a dismal prognosis. Cuproptosis, a novel mechanism mediated by protein lipoylation, results in acute proteotoxic stress and ultimately cell death. Ho...
Familial pancreatic cancer [0.03%]
家族性胰腺癌
Lorenzo Del Nero,Emanuele Dabizzi,Antonella De Ceglie et al.
Lorenzo Del Nero et al.
Pancreatic cancer (PC) carries a poor prognosis with an overall 5-year survival of less than 10%. Early diagnosis, though cumbersome, is essential to allow complete surgical resection. Therefore, primary and secondary prevention are critica...
Development and validation of a multivariable risk factor questionnaire to detect oesophageal cancer in 2-week wait patients [0.03%]
用于诊断两周等待患者食道癌的多因素风险评估问卷的建立与验证
Kai Man Alexander Ho,Avi Rosenfeld,Áine Hogan et al.
Kai Man Alexander Ho et al.
Introduction: Oesophageal cancer is associated with poor health outcomes. Upper GI (UGI) endoscopy is the gold standard for diagnosis but is associated with patient discomfort and low yield for cancer. We used a machine l...
2D shear wave elastography of the rectus femoris muscle in patients with cirrhosis: Feasibility and clinical findings. A pilot study [0.03%]
肝硬化患者股直肌二维剪切波弹性成像的可行性及临床发现。初步研究
Chiara Becchetti,Naomi F Lange,Maria Gabriela Delgado et al.
Chiara Becchetti et al.
Background and aims: Frailty is frequent in cirrhosis and associated with skeletal muscle abnormalities and worse prognosis. 2D shear-wave elastography (2D-SWE) could mirror biomechanical properties of skeletal muscle ref...
The research progress of Wnt/β-catenin signaling pathway in colorectal cancer [0.03%]
Wnt/β-catenin信号通路在结直肠癌研究中的进展
Xueling Zhang,Congcong Li,Yue Wu et al.
Xueling Zhang et al.
The Wnt/β-catenin signaling pathway is highly conservative. β-catenin is the key molecule in this pathway. The β-catenin target genes regulate cell proliferation and apoptosis. Since Wnt pathway proteins are distributed on the cell membr...
Which liver transplant patients will become octogenarians? A French single-center study [0.03%]
哪些肝移植患者能成为八旬老人？一项法国单中心研究
Jérôme Dumortier,Olivier Guillaud,Olivier Boillot
Jérôme Dumortier
Efficacy and safety of HER2-targeted therapy in patients with colorectal cancer: What should we expect from a meta-analysis? [0.03%]
HER2靶向治疗在结直肠癌患者中的有效性和安全性：我们能从荟萃分析中期待什么？
Menglei Wang,Jingyang Su,Jinhua Lu et al.
Menglei Wang et al.
Background and objective: Human epidermal growth factor receptor 2 (HER2) is an effective therapeutic target for breast and stomach cancers. However, the application of HER2-targeted therapy in colorectal cancer (CRC) rem...
Clinical application study on miR-98-5p as a prognostic biomarker in hepatocellular carcinoma [0.03%]
miR-98-5p作为肝细胞癌预后生物标志物的临床应用研究
Peng-Tian Ji,Xiao-Yan Wang
Peng-Tian Ji
Background: On the one hand, to investigate the targeted regulation of miR-98-5p on heparin-binding epidermal growth factor-like growth factor (HBEGF) in patients with hepatocellular carcinoma (HCC). On the other hand, el...
The detection rate of granulomas differs between intestinal segments and lesions in Chinese patients with Crohn's disease [0.03%]
克罗恩病患者肠道各段和病灶肉芽肿检出率的差异性研究
Lin-Teng Chen,Jin-Yan Zhang,Jian-Wei Zheng et al.
Lin-Teng Chen et al.
Background: Crohn's disease (CD) is characterized by non-caseating intestinal granulomas. However, the reported detection rate of granulomas on endoscopy is low. This study aimed to analyze the differences in the detectio...
Transarterial chemoembolization failure in patients with hepatocellular carcinoma: Incidence, manifestation and risk factors [0.03%]
肝细胞癌患者的经动脉化疗栓塞失败：发生率、表现和危险因素
Lijie Zhang,Xin Zhang,Qing Li et al.
Lijie Zhang et al.
Background: To identify the incidence, manifestation and risk factors of transarterial chemoembolization (TACE) failure defined as untreatable progression (UP) in patients with hepatocellular carcinoma (HCC) on short-term...