ZNF300 promotes proliferation and migration of hepatocellular carcinoma by upregulating c-MYC gene expression [0.03%]
锌指蛋白300通过上调c-MYC基因表达促进肝癌细胞增殖和迁移
Wei Xiang,Junwei Ni,Liyang Dong et al.
Wei Xiang et al.
Background: Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver. Currently, the treatments of HCC are limited to surgical resection and liver transplantation, and there is no effective s...
Liquid biopsy as a tool for KRAS/NRAS/BRAF baseline testing in metastatic colorectal cancer [0.03%]
液体活检在转移性结直肠癌KRAS/NRAS/BRAF基线检测中的应用价值研究
Hampig Raphael Kourie,Joseph Zouein,Ziad Zalaquett et al.
Hampig Raphael Kourie et al.
Background: The absence of KRAS and NRAS gene mutations (RAS wild type) in metastatic colorectal cancer (mCRC), is associated with a good response to targeted therapy with anti-EGFR receptor antibodies. The current gold s...
Pharidah Rajan Ibrahim Omar Sundi,Velaphi C Thipe,Mohamed Abdullahi Omar et al.
Pharidah Rajan Ibrahim Omar Sundi et al.
Hepatocellular carcinoma (HCC) is the most frequent liver cancer, which account for more than 90 % of all liver cancer cases. It is the fifth leading cause of cancer globally and the second leading cause of cancer-related mortality in men. ...
Quiescent hepatic stellate cell activation in liver fibrosis: Have we found the right trigger yet? [0.03%]
肝纤维化中静息肝星状细胞活化的触发因素找到了吗？
Devaraj Ezhilarasan,Mustapha Najimi
Devaraj Ezhilarasan
Spermine oxidase regulates liver inflammation and fibrosis through β-catenin pathway [0.03%]
精胺氧化酶通过β-连环蛋白信号通路调节肝炎和肝纤维化
Tingting Hu,Wenqing Tang,Wandong Hong et al.
Tingting Hu et al.
Background: Spermine oxidase (SMOX), an inducible enzyme involved in the catabolic pathway of polyamine, was found to be upregulated in hepatocellular carcinoma and might be an important oncogene of it in our previous stu...
Sinomenine hydrochloride improves DSS-induced colitis in mice through inhibition of the TLR2/NF-κB signaling pathway [0.03%]
盐酸汉防己甲素通过抑制TLR2/NF-κB信号通路改善DSS诱导的小鼠结肠炎
Huimin Zhang,Hailun Zheng,Qizhi Wang et al.
Huimin Zhang et al.
Background: Sinomenine hydrochloride (SH) has anti-inflammatory and immunosuppressive effects, and its effectiveness in inflammatory diseases, such as rheumatoid arthritis, has been demonstrated. However, whether SH has a...
Association between primary biliary cholangitis with diabetes and cardiovascular diseases: A bidirectional multivariable Mendelian randomization study [0.03%]
基于孟德尔随机化方法研究原发性胆汁性肝硬化与糖尿病和心血管疾病的相关性：双向多变量孟德尔随机化研究
Yun-Lu Lin,Tao Yao,Ying-Wei Wang et al.
Yun-Lu Lin et al.
Background and aims: Primary biliary cholangitis (PBC) is an autoimmune disease often accompanied by multisystem damage. This study aimed to explore the causal association between genetically predicted PBC and diabetes, a...
Palliative care and end stage liver disease: a survey study comparing perspectives of hepatology and palliative care physicians and clinical scenarios that could require palliative care intervention [0.03%]
肝病终末期的姑息治疗：肝病医生和姑息治疗医生观点的调查研究以及可能需要姑息干预的临床场景分析
Hugo Miguel Oliveira,José Presa Ramos,Francisca Rego et al.
Hugo Miguel Oliveira et al.
Background and aims: The prevalence and mortality of chronic liver disease has risen significantly. In end stage liver disease (ESLD) the survival of patients is approximately 2 years. Despite the poor prognosis and high ...
Validation of a novel BCM model for recurrence risk prediction after mucosectomy of colorectal lateral spreading tumors in a European cohort [0.03%]
欧洲队列中验证一种新型BCM模型以预测黏膜内切除的侧向发育型结直肠肿瘤术后复发风险
Sofia Bragança,Ana Catarina Garcia,Gonçalo Alexandrino et al.
Sofia Bragança et al.
Background and aim: Piecemeal endoscopic mucosal resection (pEMR) is the best approach to resect large lateral spreading tumors (LST, > 20 mm width). However, it is associated with early recurrence (ER) and late recurrenc...
Strong association between sarcopenic obesity and non-alcoholic fatty liver disease: An observational study with ISarcoPRM algorithm [0.03%]
低肌肥胖与非酒精性脂肪肝强关联：一项使用ISarcoPRM算法的观察研究
Selim Demirci,Semih Sezer,Kübra Erdoğan et al.
Selim Demirci et al.
Background: In recent times, sarcopenia and non-alcoholic fatty liver disease (NAFLD) have garnered widespread attention in public health. Nevertheless, the relationship between sarcopenia and NAFLD remains uncertain. Thi...