Reconsidering the Post-SVR Landscape: Clinical Implications of Rising Steatosis Despite Fibrosis Regression [0.03%]
重新考虑SVR后的治疗格局：脂肪变性增加而纤维化减少的临床意义
Nathkapach Kaewpitoon Rattanapitoon,Nav La,Schawanya Kaewpitoon Rattanapitoon
Nathkapach Kaewpitoon Rattanapitoon
The recent work by Shengir et al. offers compelling insight into the evolving metabolic landscape following hepatitis C virus (HCV) eradication via direct-acting antivirals (DAAs). While liver stiffness and fibrosis indices significantly im...
Percutaneous transhepatic bilio-enteric neoanastomosis via the transseptal puncture system in a child with split liver transplant and severe occluded hepatico-jejunostomy [0.03%]
儿童半肝移植术后胆道狭窄的经皮经分隔穿刺途径胆肠新吻合术
Guglielmo Paolantonio,Claudia Benassi,Gian Luigi Natali
Guglielmo Paolantonio
Pediatric split liver transplantation can be frequently complicated with stenosis of the hepatico-jejunostomy, a high-morbidity outcome that might progress to secondary biliary cirrhosis and require re-transplantation if left untreated. Per...
The Association Between Metabolic-Associated Fatty Liver Diseases and Risk of Colorectal Polyps, Neoplasia, and Cancer: A Systematic Review and Meta-Analysis of over 56 million individuals [0.03%]
代谢相关性非酒精性脂肪肝与结直肠息肉、肿瘤和癌症风险的关联：超过5600万人的系统评价和meta分析
Amir Azimi,Amir Ghaffari Jolfayi,Vida Rezayifar et al.
Amir Azimi et al.
Background and aims: Non-alcoholic fatty liver disease (NAFLD) and metabolic-associated fatty liver disease (MAFLD) affect over 30% of the global population. Extrahepatic manifestations, including colorectal malignancies,...
Kuan-Fu Liao,Shih-Wei Lai
Kuan-Fu Liao
Steatosis Non-Invasive Tests Accurately Predict Metabolic Dysfunction-Associated Steatotic Liver Disease, While Fibrosis Non-Invasive Tests Fall Short: Validation in U.S. Adult Population [0.03%]
代谢异常相关性非酒精性脂肪性肝病的无创检测准确性优于纤维化的无创检测：在美国成年人群中的验证研究
Ayesha Sualeheen,Sze-Yen Tan,Robin M Daly et al.
Ayesha Sualeheen et al.
Introduction: Metabolic dysfunction associated steatotic liver disease (MASLD) has replaced NAFLD as the diagnostic standard. This study aimed to validate non-invasive tests (NITs) for hepatic steatosis and fibrosis, orig...
Specific Association and Independent Predictive Value of HBV RNA in the Disease Progression of Hepatitis B with Low-Level Viremia [0.03%]
低病毒血症乙肝患者HBV RNA的特异关联及独立预后价值分析
Liang Xu,Bin Yin,Dandan Chen et al.
Liang Xu et al.
Background and objective(s): HBV RNA serve as a downstream transcriptional product of cccDNA within the liver. This study is the first to investigate the diagnostic significance of serum HBV RNA in HBV low-level viremia (...
The Impact of Low HER2 expression on clinicopathological features and clinical outcomes in patients with metastatic gastric cancer [0.03%]
低HER2表达对转移性胃癌临床病理特征及预后的影响
Murad Guliyev,Shamkhal Safarov,Murat Günaltılı et al.
Murad Guliyev et al.
Background: Metastatic gastric cancer (GC) is an extremely fatal malignant disease. Human epidermal growth factor receptor 2 (HER2) is an important therapeutic target in patients with HER2 overexpression or gene amplifica...
Involvement of oxidative stress, lipid dysmetabolism and gut microbiol dysbiosis in oxaliplatin-induced fatty liver disease: evidence from a tree shrew model [0.03%]
氧化应激、脂质代谢紊乱和肠道菌群失调在奥沙利铂诱导的脂肪肝病中的作用：来源于裸小鼠模型的证据
Yulei Lu,Fei Yi,Wende Chen et al.
Yulei Lu et al.
Background: Oxaliplatin is cornerstone treatment for colorectal cancer, yet a significant proportion of patients develop drug-induced fatty liver disease (DILI). How it induces such liver injury is poorly understood and w...
Hepatic organoids as a platform for liver disease modeling and the development of novel therapies [0.03%]
基于肝脏类器官的肝病模型建立及新药开发研究进展
E Luce,A Messina,J C Duclos-Vallée
E Luce
Background and aims: Liver diseases pose a major global health burden, and progress in understanding liver pathophysiology and therapeutic development is hampered by the lack of predictive human models. Hepatic organoids ...