Depletion of lncRNA MEG3 Ameliorates Imatinib-Induced Injury of Cardiomyocytes via Regulating miR-129-5p/HMGB1 Axis [0.03%]
长链非编码RNA MEG3通过调节miR-129-5p/HMGB1轴缓解伊马替尼诱导的心肌细胞损伤
Peng Tang,Jinjian Zhou,Huagang Liu et al.
Peng Tang et al.
Imatinib is a classical targeted drug to treat chronic myeloid leukemia (CML). However, it shows cardiotoxicity, which limits its clinical application. Long noncoding RNA (lncRNA) maternally expressed gene 3 (MEG3) shows proapoptotic proper...
Inhibitory Effect of β-Sitosterol on the Ang II-Induced Proliferation of A7r5 Aortic Smooth Muscle Cells [0.03%]
β-谷固醇对ang ii诱导的a7r5主动脉平滑肌细胞增殖的抑制作用
Yuankun Chen,Shumiao He,Ao Zeng et al.
Yuankun Chen et al.
Objective: To explore the effects of β-sitosterol on VSMC proliferation. Materials and methods: A7r5 cells were pretreated with 2 µM ...
METTL16 Inhibits the Malignant Progression of Epithelial Ovarian Cancer through the lncRNA MALAT1/ β-Catenin Axis [0.03%]
METTL16通过lncRNA MALAT1/β-catenin轴抑制上皮性卵巢癌恶性进展
Changshu Li,Ji Liu,Yuanyuan Lyu et al.
Changshu Li et al.
Epithelial ovarian cancer (EOC) ranks third in the incidence of gynecological malignancies. m6A methylation as RNA modification plays a crucial role in the evolution, migration, and invasion of various tumors. However, the role of m6A methy...
Low-Density Lipoprotein Contributes to Endometrial Carcinoma Cell Proliferation, Migration, and Invasion by Activating the JAK-STAT Signaling Pathway [0.03%]
低密度脂蛋白通过激活JAK-STAT信号通路促进子宫内膜癌细胞增殖、迁移和侵袭
Lifan Shen,Chen Zhang,Kaiying Cui et al.
Lifan Shen et al.
Background: Cholesterol-rich low-density lipoprotein (LDL) particles have been demonstrated to regulate breast cancer cell proliferation and migration, but their biological function and relevant mechanisms in endometrial ...
Machine Learning Developed a Programmed Cell Death Signature for Predicting Prognosis, Ecosystem, and Drug Sensitivity in Ovarian Cancer [0.03%]
机器学习开发出预测卵巢癌预后、生态系统和药物敏感性的程序性细胞死亡标志物模型
Le Wang,Xi Chen,Lei Song et al.
Le Wang et al.
Background: Ovarian cancer (OC) is the leading cause of gynecological cancer death and the fifth most common cause of cancer-related death in women in America. Programmed cell death played a vital role in tumor progressio...
miR-432-5p Inhibits the Ferroptosis in Cardiomyocytes Induced by Hypoxia/Reoxygenation via Activating Nrf2/SLC7A11 Axis by Degrading Keap1 [0.03%]
miR-432-5p通过降解Keap1激活Nrf2/SLC7A11轴抑制缺氧复氧诱导的心肌细胞铁死亡
Wei Geng,Shaohua Yan,Xinyue Li et al.
Wei Geng et al.
Early reperfusion into the myocardium after ischemia causes myocardial ischemia-reperfusion (I/R) injury and ferroptosis was involved. Ischemia activates the expression of a series of oxidative stress genes and their downstream regulatory g...
Selenium Donor Inhibited Hepatitis B Virus Associated Hepatotoxicity via the Apoptosis and Ferroptosis Pathways [0.03%]
硒 donors通过凋亡和铁死亡途径抑制乙型肝炎病毒相关肝毒性
Jingdong Shi,Zhen Liu,Weina Li et al.
Jingdong Shi et al.
Methods: The serum selenium level was determined in 45 patients with HBV-positive HCC (HBV+-HCC group), 45 patients with chronic hepatitis B virus infection (CHB group), and 45 healthy cases (HC group). The sodium selenit...
Overexpression of Bruton Tyrosine Kinase Inhibits the Proliferation, Migration, and Invasion of Non-Small Cell Lung Cancer Cells [0.03%]
布氏酪氨酸激酶过表达抑制非小细胞肺癌细胞的增殖、迁移和侵袭
Wenjia Ren,Cheng Yue,Linjun Liu et al.
Wenjia Ren et al.
Lung cancer is one of the most lethal malignant tumors in the world. Non-small cell lung cancer (NSCLC) is the most common pathological subtype. However, the molecular mechanism of NSCLC progress is still unclear. We extracted the expressio...
Mesenchymal Stem Cell-Derived Exosomal miRNA-222-3p Increases Th1/Th2 Ratio and Promotes Apoptosis of Acute Myeloid Leukemia Cells [0.03%]
间充质干细胞源外泌体携带的miRNA-222-3p可通过增加Th1/Th2比值促进急性髓系白血病细胞凋亡
Yuan Yuan,Shengfen Tan,Huanhuan Wang et al.
Yuan Yuan et al.
Interferon regulatory factor 2 (IRF2) participates in the differentiation of immune T cells. Bone marrow mesenchymal stem cell (BM-MSC)-derived exosomes can secret mRNA, miRNAs, and proteins to regulate tumor microenvironment. The present s...
Brain Renin-Angiotensin System: From Physiology to Pathology in Neuronal Complications Induced by SARS-CoV-2 [0.03%]
SARS-CoV-2诱导的神经并发症从生理到病理的脑肾素血管紧张素系统研究
Shamseddin Ahmadi,Shiler Khaledi
Shamseddin Ahmadi
Angiotensin-converting enzyme 2 (ACE2), a key enzyme in the renin-angiotensin system (RAS), is expressed in various tissues and organs, including the central nervous system (CNS). The spike protein of severe acute respiratory syndrome coron...