LncRNA H19 Promotes Gastric Cancer Metastasis via miR-148-3p/SOX-12 Axis [0.03%]
长链非编码RNA H19通过miR-148-3p/SOX12轴促进胃癌转移
Xin Zhang,Ge Wang,Xiaoru Li et al.
Xin Zhang et al.
Background: Gastric cancer (GC) is the most common malignant tumor and ranks third in the world. LncRNA H19 (H19), one of the members of lncRNA, is overexpressed in various tumors. However, many undetermined molecular mec...
Shock Wave Therapy Alleviates Hypoxia/Reoxygenation-Induced Cardiomyocyte Injury by Inhibiting Both Apoptosis and Ferroptosis [0.03%]
冲击波通过抑制凋亡和铁死亡来缓解心肌细胞缺氧/复氧损伤
Jiannan Wang,Na Jia,Kaiyi Zhu et al.
Jiannan Wang et al.
Shock wave therapy (SWT) is a new alternative therapy for patients with severe coronary artery disease that improves myocardial ischemic symptoms by delivering low-energy shock wave stimulation to ischaemic myocardium with low-energy pulsed...
Role of miR-93-5p and Its Opposing Effect of Ionizing Radiation in Non-Small Cell Lung Cancer [0.03%]
miR-93-5p在非小细胞肺癌中的作用及其与电离辐射的拮抗效应
Qingtao Ni,Kai Sang,Jian Zhou et al.
Qingtao Ni et al.
Background: Radiation therapy is an effective local therapy for lung cancer. However, the interaction between genes and radiotherapy is multifaceted and intricate. Therefore, we explored the role of miR-93-5p in the proli...
Immunohistochemical Profile of p62/SQSTM1/Sequestosome-1 in Human Low- and High-Grade Intracranial Meningiomas [0.03%]
p62/SQSTM1/凋亡相关斑蛋白在人脑低级别和高级别脑膜瘤中的免疫组化特征分析
Antonio Ieni,Cristina Pizzimenti,Vincenzo Fiorentino et al.
Antonio Ieni et al.
Among autophagic-related proteins, p62/SQSTM1/Sequestosome-1 represents a relevant actor in cellular proliferation and neoplastic growth. Although, recently, p62 expression has been analyzed in different neurodegenerative and glial neoplast...
Construction and Identification of Eukaryotic Expression Vector pEGFP-N1-MIC-1 for Mouse MIC-1 Gene and Its Effect on Gastric Cancer Cells [0.03%]
胃癌细胞中鼠源MIC-1基因的真核表达载体pEGFP-N1-MIC-1的构建、鉴定及其作用效应研究
HuiPeng Zhang,Zhongyu Qin,ShuaiShuai Shi et al.
HuiPeng Zhang et al.
This study aimed to construct an eukaryotic expression vector, pEGFP-N1-MIC-1, for overexpressing the mouse macrophage inhibitory cytokine-1 (MIC-1) gene. Additionally, we transfected the MFC cell line to observe the upregulation of MIC-1 g...
Synergistic Effects of Icariin and Extracellular Vesicles Derived from Rabbit Synovial Membrane-Derived Mesenchymal Stem Cells on Osteochondral Repair via the Wnt/ β-Catenin Pathway [0.03%]
淫羊藿素和兔滑膜间充质干细胞源外泌体通过Wnt/β-catenin信号通路协同促进软骨下骨修复的作用研究
Dongming Tang,Wang Tang,Huanqing Chen et al.
Dongming Tang et al.
Objectives: Osteochondral defects (OCDs) are localized areas of damaged cartilage and underlying subchondral bone that can produce pain and seriously impair joint function. Literature reports indicated that icariin (ICA) ...
Combination of Pirfenidone and Andrographolide Ameliorates Hepatic Stellate Cell Activation and Liver Fibrosis by Mediating TGF- β/Smad Signaling Pathway [0.03%]
穿心莲内酯联合吡非尼酮通过调节TGF-β/smad信号通路改善肝星状细胞活化和肝纤维化的研究
Guang Xu,Tidong Ma,Chonggao Zhou et al.
Guang Xu et al.
Background: Biliary atresia (BA) is a devastating congenital disease characterized by inflammation and progressive liver fibrosis. Activation of hepatic stellate cells (HSCs) plays a central role in the pathogenesis of he...
FAP Serves as a Prognostic Biomarker in Head and Neck Squamous Cell Carcinoma [0.03%]
FAP可作为头颈部鳞状细胞癌的预后生物标志物
Zhanpeng Liao,Haidong Fan,Junquan Weng et al.
Zhanpeng Liao et al.
Head and neck squamous cell carcinoma (HNSCC) poses significant challenges with poor survival rates and limited therapeutic strategies. Our study, using The Cancer Genome Atlas (TCGA) data, assesses cancer-associated fibroblast (CAF) gene s...
Identification of circRNA Expression Profile and Potential Systemic Immune Imbalance Modulation in Premature Rupture of Membranes [0.03%]
circRNA表达谱的鉴定及其在胎膜早破系统性免疫失衡调节中的潜在作用
Dongni Huang,Yuxin Ran,Ruixin Chen et al.
Dongni Huang et al.
Premature rupture of membrane (PROM) refers to the rupture of membranes before the onset of labor which increases the risk of perinatal morbidity and mortality. Recently, circular RNAs (circRNAs) have emerged as promising regulators of dive...
Regulation of Cancer-Associated miRNAs Expression under Hypoxic Conditions [0.03%]
低氧条件下癌症相关miRNA表达的调节机制研究
Jesús Valencia-Cervantes,Martha Patricia Sierra-Vargas
Jesús Valencia-Cervantes
Solid tumors frequently experience hypoxia or low O2 levels. In these conditions, hypoxia-inducible factor 1 alpha (HIF-1α) is activated and acts as a transcription factor that regulates cancer cell adaptation to O2 and nutrient deprivatio...