N-Acetylcysteine Treats Spinal Cord Injury by Inhibiting Astrocyte Proliferation [0.03%]
N-乙酰半胱氨酸通过抑制星形胶质细胞增殖治疗脊髓损伤
Dong Zhang,Chaoxi Qin,Fei Meng et al.
Dong Zhang et al.
Astrocyte proliferation commonly occurs after spinal cord injury (SCI). N-Acetylcysteine (NAC) has a regulatory effect on many diseases. In this study, we investigated the effect and underlying mechanism of NAC on astrocytes in SCI. We isol...
Mitochondria-Associated Gene SLC25A32 as a Novel Prognostic and Immunotherapy Biomarker: From Pan-Cancer Multiomics Analysis to Breast Cancer Validation [0.03%]
线粒体相关基因SLC25A32作为新型预后和免疫治疗生物标志物：从泛癌多组学分析到乳腺癌验证
Shiqi Zuo,Siyuan He,Zhiqin Zhu et al.
Shiqi Zuo et al.
Background: Mutations in SLC25A32 in humans cause late-onset exercise intolerance, which is associated with various neurological and metabolic diseases. However, its specific mechanism of action in tumour development is p...
Shikonin Induces Autophagy and Apoptosis in Esophageal Cancer EC9706 Cells by Regulating the AMPK/mTOR/ULK Axis [0.03%]
漆酚通过调节AMPK/mTOR/ULK信号轴诱导食管癌EC9706细胞自噬和凋亡
Junli Zhang,Jiayi Guo,Biao Gu et al.
Junli Zhang et al.
Shikonin is a plant medicine extracted from Lithospermum, which dominate influential antioxidant and antitumor effect. Here, we report that shikonin was capable of inducing human esophageal cancer EC9706 cell apoptosis and autophagy, in a t...
Hippo Signaling Pathway in Colorectal Cancer: Modulation by Various Signals and Therapeutic Potential [0.03%]
hippo信号通路在结直肠癌中的调控及治疗潜能
Somayeh Mohammadpour,Amir Torshizi Esfahani,SeyedKasra Sarpash et al.
Somayeh Mohammadpour et al.
Colorectal cancer (CRC) stands as a significant global health issue, marked by elevated occurrence and mortality statistics. Despite the availability of various treatments, including chemotherapy, radiotherapy, and targeted therapy, CRC cel...
Exosomal PDL1 Suppresses the Anticancer Activity of CD8+ T Cells in Hepatocellular Carcinoma [0.03%]
外泌体PDL1在肝细胞癌中抑制CD8+t细胞的抗癌活性
Qi Hu,Shuai Chen,Rilin Deng et al.
Qi Hu et al.
Tumor microenvironment (TME) is essential for the development and progression of hepatocellular carcinoma (HCC). Exosomes participate in constructing TME by passing biological information, but the regulatory effect of PDL1 in exosomes on an...
AZD8055 Is More Effective Than Rapamycin in Inhibiting Proliferation and Promoting Mitochondrial Clearance in Erythroid Differentiation [0.03%]
AZD8055抑制增殖及促进红系分化线粒体自噬的能力优于雷帕霉素
Qian Liu,Tao Hao,Ze Lin et al.
Qian Liu et al.
Background: As an important downstream effector of various signaling pathways, mTOR plays critical roles in regulating many physiological processes including erythropoiesis. It is composed of two distinct complexes, mTORC1 and mTORC2, which...
Malignant Transformation of Normal Oral Tissue to Dysplasia and Early Oral Squamous Cell Carcinoma: An In Silico Transcriptomics Approach [0.03%]
正常口腔组织向发育不全和早期口腔鳞状细胞癌恶性转化的转录组学研究
Shokoofeh Jamshidi,Matina Tavangar,Setareh Shojaei et al.
Shokoofeh Jamshidi et al.
Background: Oral squamous cell carcinoma (OSCC) is a prevalent and aggressive form of head and neck cancer, often diagnosed at advanced stages. Elucidating the molecular mechanisms involved in the malignant transformation from normal oral t...
Astragaloside IV Protects against Shear Stress-Induced Glycocalyx Damage and Alleviates Abdominal Aortic Aneurysm by Regulating miR-17-3p/Syndecan-1 [0.03%]
Astragaloside Ⅳ通过调控miR-17-3p/SYNDECAN-1信号通路保护血管 glycocalyx抵抗剪切力损伤及治疗腹主动脉瘤的作用研究
Guojian Li,Qionghui Yang,Kaikai Luo et al.
Guojian Li et al.
Background: The present study aimed to analyze the impact of astragaloside IV (AS-IV) on abdominal aortic aneurysm (AAA) and the glycocalyx, elucidating the potential mechanism of AS-IV. ...
LINC01614 Promotes Colorectal Cancer Cell Growth and Migration by Regulating miR-217-5p/HMGA1 Axis [0.03%]
长链非编码RNA LINC01614通过调控miR-217-5p/HMGA1轴促进结直肠癌细胞增殖和迁移
Jiwei Jia,Pei Guo,Li Zhang et al.
Jiwei Jia et al.
Colorectal cancer (CRC) substantially contributes to cancer-related deaths worldwide. Recently, a long non-coding RNA (lncRNA), LINC01614, has emerged as a vital gene regulator in cancer progression. Yet, how LINC01614 affects CRC progressi...
Development of a Novel KCNN4-Related ceRNA Network and Prognostic Model for Renal Clear Cell Carcinoma [0.03%]
开发与KCNN4相关的新型ceRNA网络和肾透明细胞癌预后模型
Hengtao Bu,Qiang Song,Jiexiu Zhang et al.
Hengtao Bu et al.
Background: Clear cell renal cell carcinoma (ccRCC) accounts for more than 80% of renal cell carcinomas. Yet, it has not been fully understood about the derivation and progression of the tumor, as well as the long-term be...