Decoding Osteosarcoma's Lactylation Gene Expression: Insights Into Prognosis, Immune Dynamics, and Treatment [0.03%]
破译骨肉瘤的乳酰化基因表达：对预后、免疫动态和治疗的见解
Cheng Peng,Chaoqun You,Shuang Cao et al.
Cheng Peng et al.
Osteosarcoma (OS), characterized by a complex tumor microenvironment, poses challenges in treatment, metastasis, and therapy resistance. This study examined the impact of lactylation, a posttranslational modification, on gene expression and...
The Association of VDR/FokI Gene Polymorphism and Protein Expression With Histopathological Alterations in Patients With Thyroid Colloid Nodule [0.03%]
甲状腺胶性结节患者VDR/FokI基因多态性和蛋白表达与病理性改变的关联性研究
Mariwan F Abdalfatah,Abdullah A Shareef,Lana S Saleh et al.
Mariwan F Abdalfatah et al.
Objective: Colloid nodules are common and benign thyroid lesions that usually progress slowly and are asymptomatic. It requires follow-up because untreated colloid nodules may develop into malignant tumor. The study aimed to examine the con...
Circular RNA Circ_0079226 Plays an Oncogenic Role in Gastric Cancer via the miR-155-5p/FOXK1/AKT Pathway [0.03%]
环状RNA Circ_0079226通过miR-155-5p/FOXK1/AKT通路在胃癌中发挥致癌作用
Hui Zhang,Zhisheng Huang,Yingyun Zhong
Hui Zhang
Background: Circular RNA (circRNA) is implicated in various biological processes, including the progression of gastric cancer (GC). The specific functions and underlying mechanisms of circ_0079226 in GC are unknown. Methods: We examined can...
SLC1A4 Promotes Malignant Transformation of Hepatocellular Carcinoma by Activating the AKT Signaling [0.03%]
SLC1A4通过激活AKT信号促进肝细胞癌恶性转化
Jiaoyun Zheng,Jian Gong
Jiaoyun Zheng
Due to the difficulty in early diagnosis and the lack of treatment for advanced disease, the mortality rate of hepatocellular carcinoma (HCC) is high, and the 5-year overall survival rate is low at present. SLC1A4 is a neutral amino acid tr...
DDX21 Is a Potential Biomarker for Predicting Recurrence and Prognosis in Hepatocellular Carcinoma [0.03%]
DDX21是预测肝细胞癌复发和预后的潜在生物标志物
Chengjie Ji,Qing Zhong,Huilan Su et al.
Chengjie Ji et al.
DEAD-box helicase 21 (DDX21) is a conserved Asp-Glu-Ala-Asp (DEAD) box RNA helicase with multiple functions that is involved in various cellular processes and diseases. However, the role of DDX21 in the recurrence and prognosis of hepatocel...
Development of a Novel Prognostic Model for Lung Adenocarcinoma Utilizing Pyroptosis-Associated LncRNAs [0.03%]
利用焦亡相关长链非编码RNA构建肺腺癌预后模型
Hong-Yan Bai,Tian-Tian Li,Li-Na Sun et al.
Hong-Yan Bai et al.
Lung cancer is a highly prevalent and fatal cancer that seriously threatens the safety of people in various regions around the world. Difficulty in early diagnosis and strong drug resistance have always been difficulties in the treatment of...
High Glucose-Induced Senescent Fibroblasts-Derived Exosomal miR-497 Inhibits Wound Healing by Regulating Endothelial Cellular Autophagy via ATG13 [0.03%]
高糖诱导成纤维细胞源外泌体miR-497通过ATG13调节内皮细胞自噬抑制伤口愈合
Changjiang Liu,Yuting Liu,Yifeng Yu et al.
Changjiang Liu et al.
Background: Fibroblasts play a crucial role in diabetic wound healing, and their senescence is the cause of delayed wound repair. It was reported that fibroblasts can secrete exosomes that can mediate a vital role in diabetic complications....
circ-ZEB1 Enhances NSCLC Metastasis and Proliferation by Modulating the miR-491-5p/EIF5A Axis [0.03%]
circ-ZEB1通过调控miR-491-5p/EIF5A轴促进NSCLC转移和增殖
Qi Wang,Shengying Ling,Jia Lv et al.
Qi Wang et al.
Background: Circular RNAs (circRNAs), covalently closed single-stranded RNAs, have been implicated in cancer progression. A previous investigation revealed that circ-ZEB1 is expressed abnormally in liver cancer. However, the roles of circ-Z...
Gold Nanoparticle Inhibits the Tumor-Associated Macrophage M2 Polarization by Inhibiting m6A Methylation-Dependent ATG5/Autophagy in Prostate Cancer [0.03%]
金纳米颗粒通过抑制m6A甲基化依赖的ATG5/自噬来抑制前列腺癌相关巨噬细胞M2极化
Yuanyuan Hao,Feng Duan,Xianning Dong et al.
Yuanyuan Hao et al.
Background: This study aims to study how gold nanoparticles (AuNPs) function in the recruitment and polarization of tumor-associated macrophages (TAMs) in hormone-sensitive prostate cancer (HSPC) and castration-resistant prostate cancer (CR...
Exploring the Research Focus of RNA-Binding Proteins in Trauma and Burns [0.03%]
探究RNA结合蛋白在创伤与烧伤中的研究焦点
Sujie Xie,Yifan Liu,Wei Zhang et al.
Sujie Xie et al.
Background: Trauma and burns are leading causes of death and significant global health concerns. RNA-binding proteins (RBPs) play a crucial role in post-transcriptional gene regulation, influencing various biological processes of cellular R...