PYCR1 Downregulation Induces Autophagy Dependent Apoptosis Through Inhibiting PI3K/AKT/mTOR Axis in Human Hepatocellular Carcinoma Cells [0.03%]
下调PYCR1通过抑制PI3K/AKT/mTOR轴诱导自噬依赖性凋亡在人类肝癌细胞中的作用研究
Junli Zhang,Yachao Hou,Xinxin Jin et al.
Junli Zhang et al.
Background: Hepatocellular carcinoma (HCC) is a global malignant tumor type. Pyrroline-5-carboxylate reductase 1 (PYCR1) is a metabolic enzyme that exhibits pro-tumor properties in cancer progression. However, the exact m...
Regulation of Cell Function and Myeloid-Derived Suppressor Cell Chemotaxis by hsa_circ_0006466-miR-1286-PDGFRA/B Axis in Triple Negative Breast Cancer [0.03%]
circRNA-has-circ-0006466通过miR-1286-PDGFRA/B轴调控三阴性乳腺癌细胞功能和髓源抑制性细胞趋化作用
Fengqin Gao,Mingkai Gong,Yufeng Cao et al.
Fengqin Gao et al.
Background: Circular RNAs (circRNAs) play critical regulatory roles in diverse biological processes of breast cancer. This study aimed to investigate the circRNAs potentially related to immunity in triple-negative breast ...
Identification of Potential Therapeutic Agents for Primary Amebic Meningoencephalitis Using Text Mining and Bioinformatics Analyses [0.03%]
基于文本挖掘和生物信息学分析鉴定原发性阿米巴脑膜脑炎的潜在治疗药物
Eun Jung Sohn,Hyeonseo Jo,Kun Taek Park
Eun Jung Sohn
Naegleria fowleri, the brain-eating ameba, causes primary amebic meningoencephalitis (PAM), a fatal infectious disease that affects the central nervous system (CNS). We aimed to evaluate the functions and potential drugs targeting PAM using...
CCDC97 is a Promising Predictor in Cancer Diagnosis: A Pan Cancer Analysis [0.03%]
CCDC97在癌症诊断中是一个有前景的预测因子：泛癌分析
Changye Yang,Ruirui Yang,Rundong Wang et al.
Changye Yang et al.
Background: Coiled-coil domain-containing 97 (CCDC97) can bind to the splicing factor SF3B complex to participate significantly in pre-mRNA splicing. However, there may be a risk of cancer development in the case of disru...
THBS2 Promotes Prostate Cancer Malignancy via INHBA-Dependent FAK/PI3K/AKT Signaling Activation [0.03%]
THBS2通过INHBA依赖性FAK/PI3K/AKT信号激活促进前列腺癌恶性进展
Yifeng Yao,Yiyang Guo,Shoulei Liu et al.
Yifeng Yao et al.
Prostate cancer (PCa) is a leading malignancy among men, with a growing incidence and mortality rate worldwide. There is a pressing need to identify novel molecular biomarkers and therapeutic targets to improve prognosis and treatment strat...
How the Fibrotic Lung Microenvironment Regulates Stem Cell Behavior: Immune Cues, Extracellular Matrix Remodeling, and Therapeutic Implications [0.03%]
纤维化肺微环境如何调节干细胞行为：免疫线索、细胞外基质重塑及治疗意义
Zihan Zhou,Shuhua Han,Yuanfang Duan et al.
Zihan Zhou et al.
Pulmonary fibrosis (PF) is a chronic and progressive interstitial lung disease characterized by excessive extracellular matrix (ECM) deposition and remodeling of lung structures. Currently, no effective clinical treatments exist to reverse ...
Xinlikang Capsule Alleviates Chemotherapy-Induced Fatigue by Inhibiting the PI3K/AKT-mTOR-FoxO Pathway [0.03%]
欣力康胶囊通过抑制PI3K/AKT-mTOR-FoxO途径缓解化疗引起的疲劳反应
Suzhou Huang,Yiheng Zhang,Tianle Ma et al.
Suzhou Huang et al.
Objective: Chemotherapy-induced fatigue (CIF) remains a clinically challenging condition with limited therapeutic options. This study aimed to elucidate the therapeutic potential and underlying mechanisms of the multiherb...
Apoptosis, Cell Cycle and Differentiation Effects of Propolis Extracted in Olive Oil on HL-60 AML Cells: A Flow Cytometric Analysis [0.03%]
橄榄油提取的蜂胶对HL-60急性髓系白血病细胞凋亡、细胞周期和分化作用的流式分析研究
Hamide Dogan,A Ata Ozcimen,Erkan Alabas et al.
Hamide Dogan et al.
In recent years, researchers have focused on the drug capacity of natural products and their components with low side effects in the treatment of leukemia. This study aims to elucidate the antileukemic mechanism of action of olive oil extra...
Prognostic Value of UBE2S, HIF-1α, and FOXM1 Expression in Esophageal Squamous Cell Carcinoma [0.03%]
UBE2S、HIF-1α和FOXM1表达在食管鳞癌中的预后价值
Wan Li,Keming Zhou,Mengyan Li et al.
Wan Li et al.
Objective: The present investigation was aimed to examine ubiquitin-conjugating enzyme E2S (UBE2S), hypoxia-inducible factor (HIF)-1α, and factor forkhead box M1 (FOXM1) levels in esophageal squamous cell carcinoma (ESCC...
m6A-Mediated Stabilization of PRMT9 mRNA by IGF2BP1 Drives Proliferation and Metastasis in Lung Adenocarcinoma [0.03%]
IGF2BP1介导的m6A修饰稳定PRMT9 mRNA驱动肺腺癌增殖和转移
Jinghua Chen,Jiahao Yang,Zihao Chen et al.
Jinghua Chen et al.
Background: Protein arginine methyltransferase 9 (PRMT9) is dysregulated in various malignancies, particularly in lung adenocarcinoma (LUAD). This study aims to systematically investigate the expression patterns, biologic...