Mitochondrial DNA Sensing Pathogen Recognition Receptors in Systemic Sclerosis Associated Interstitial Lung Disease: A Review [0.03%]
线粒体DNA识别受体在系统性硬化症相关间质性肺疾病中的研究进展
Alexander Ghincea,Samuel Woo,Sheeline Yu et al.
Alexander Ghincea et al.
Purpose of the review: Systemic sclerosis (SSc) is a condition of dermal and visceral scar formation characterized by immune dysregulation and inflammatory fibrosis. Approximately 90% of SSc patients develop interstitial ...
Inhibiting interferon pathways in dermatomyositis: rationale and preliminary evidence [0.03%]
皮肌炎中抑制干扰素途径的理据及初步证据
Maria Casal-Dominguez,Iago Pinal-Fernandez,Andrew L Mammen
Maria Casal-Dominguez
Purpose of review: Dermatomyositis (DM) is a systemic autoimmune disease affecting multiple organs, including skeletal muscle, skin, and lungs. Although DM disease mechanisms are incompletely understood, accumulating evid...
Exercise Therapy for Knee and Hip Osteoarthritis: Is There An Ideal Prescription? [0.03%]
膝骨关节炎和髋骨关节炎的运动疗法：最佳处方是什么？
James J Young,Julie Rønne Pedersen,Alessio Bricca
James J Young
Purpose of review: Exercise therapy is the first line treatment for patients with knee and hip osteoarthritis (OA) but is consistently underutilized. In this review, we aim to provide health care professionals with an ove...
Rana S Hinman,Belinda J Lawford,Rachel K Nelligan et al.
Rana S Hinman et al.
Purpose of review: There is increasing recognition that virtual tools, enabled by the internet and telecommunications technology, can increase access to health care. We review evidence about the clinical effectiveness and...
Albert Selva-O&#x;Callaghan,Ernesto Trallero-Araguás,Javier Ros et al.
Albert Selva-O&#x;Callaghan et al.
Purpose of the review: Cancer-associated myositis (CAM) is defined as when cancer appears within 3 years of myositis onset. Dermatomyositis and seronegative immune-mediated necrotizing myopathy are the phenotypes mostly r...
Jordan L Saag,Maria I Danila
Jordan L Saag
Purpose of review: Osteoporosis management has evolved significantly over the past decade, with telehealth emerging as an effective tool to manage bone health in a growing patient population. This review explores the adva...
Elena Tsourdi,Matthew T Drake
Elena Tsourdi
Purpose of review: This review provides an overview regarding osteoporosis therapies during the COVID-19 pandemic. Recent findings: The...
Dysregulation of Type 1 Interferon Signaling in Systemic Sclerosis: a Promising Therapeutic Target? [0.03%]
系统性硬化症中Ⅰ型干扰素信号转导异常：一个有希望的治疗靶点吗？
Minghua Wu,Shervin Assassi
Minghua Wu
Purpose of review: There are several lines of evidence at the genetic and gene expression levels linking type I interferon (IFN) activation to systemic sclerosis (SSc) pathogenesis. Herein, we summarize the potential role...
Pharmacologic Treatment of Anti-MDA5 Rapidly Progressive Interstitial Lung Disease [0.03%]
抗MDA5快速进展性间质性肺疾病的药物治疗
A Selva-O&#x;Callaghan,F Romero-Bueno,E Trallero-Araguás et al.
A Selva-O&#x;Callaghan et al.
Purpose of the review: Idiopathic inflammatory myopathies are a heterogeneous group of autoimmune disorders. The presence of different autoantibodies allows clinicians to define distinct phenotypes. Antibodies against the...
Emma Weeding,Eleni Tiniakou
Emma Weeding
Purpose of review: The idiopathic inflammatory myopathies are a heterogeneous group of autoimmune disorders characterized by skeletal muscle inflammation leading to chronic muscle weakness. Immune-mediated necrotizing myo...