Neural network-aided unsupervised input function estimation for dual-time-window PET Patlak analysis [0.03%]
基于神经网络的双时间窗口PET Patlak分析无监督输入函数估计方法
Wenrui Shao,Yarong Zhang,Fen Du et al.
Wenrui Shao et al.
Purpose: This study aims to develop and validate a dual-time-window (DTW) Patlak plot method that eliminates the need for invasive blood sampling and reduces scan duration. We seek to improve the accuracy of the net influ...
Comparison of imaging-based bone marrow dosimetry methodologies and their dose-effect relationships in [177Lu]Lu-PSMA-617 RLT including a novel method with active marrow localization [0.03%]
基于影像的骨髓剂量学方法及其在[177Lu]Lu-PSMA-617放射性治疗中的剂量效应关系的比较，包括一种新的活性骨髓定位方法
Avery B Peterson,Scott J Wilderman,Johan Blakkisrud et al.
Avery B Peterson et al.
Purpose: Establishing accurate methods for red marrow (RM) dosimetry is an important step toward patient-specific treatment guidance. We compared image-based dosimetry methods and investigated their role in predicting cha...
Motion study on upright patient positioning in walk-through PET: evaluation in a clinical setting [0.03%]
立位PET显像中患者体位稳定的运动研究及临床评价
Rabia Aziz,Florence Marie Muller,Nadia Withofs et al.
Rabia Aziz et al.
Background: The novel upright walk-through PET (WT-PET) scanner enhances patient throughput compared to the conventional cylindrical PET systems but introduces unique challenges related to patient motion. This study evalu...
Diagnostic CT organ dose estimation in whole-body PET/CT examinations-comparison of a patient-specific monte carlo approach and a computational phantom-based CT dosimetry tool [0.03%]
全身PET/CT检查中的诊断CT器官剂量估算-基于患者特定蒙特卡洛方法与计算人体模型的CT剂量学工具之间的比较研究
Gwenny Verfaillie,Yves D&#x;Asseler,Klaus Bacher
Gwenny Verfaillie
Background: Studies evaluating the impact of advances in CT dosimetry tools on CT organ dose estimations are often limited to a comparison with TLD measurements in anthropomorphic phantoms or a comparison of different dos...
Monte Carlo-based subcellular comparison of electron energy deposition by 177Lu and 161 Tb: implications for targeted radiopharmaceutical therapy [0.03%]
基于蒙特卡罗的177Lu和161Tb电子能量沉积的亚细胞比较：对放射性药物治疗的意义
Alexandre França Velo,Lukas M Carter,John L Humm
Alexandre França Velo
Purpose: This study compares the subcellular dosimetry of 161 Tb and 177Lu, focusing on β⁻ particles, conversion electrons, and Auger electrons, and their relative contributions to cellular and subcellular damage. We ai...
Regional impact of time-to-equilibrium on indirect Patlak whole-body parametric imaging: a multi-tissue class analysis at the entire body level [0.03%]
时至平衡时间对间接Patlak全身参数成像区域影响的多组织类分析：全身水平上的研究
Abarnaa Sivapathasundaram,Agnieszka Buffon,Jérôme Ghidaglia et al.
Abarnaa Sivapathasundaram et al.
Purpose: Patlak parametric imaging is widely employed for kinetic modeling due to its simplicity and robustness. The time-to-equilibrium (t*), which must be defined to estimate kinetic parameters, is currently set empiric...
Predicting PSA50 response to [Formula: see text]Lu-PSMA therapy using machine learning and automated total tumor volume [0.03%]
基于机器学习和自动化总肿瘤体积预测PSA50对177Lu-PSMA治疗的反应
Eduardo Rios-Sanchez,Anne-Laure Giraudet,Alicia Sanchez-Lajusticia et al.
Eduardo Rios-Sanchez et al.
The 177Lu-PSMA therapy is an established treatment for metastatic castration-resistant prostate cancer (mCRPC), targeting the prostate-specific membrane antigen (PSMA). Despite well-established correlations between 68Ga-PSMA PET/CT imaging ...
Radiation exposure to families of patients following administration of 177Lu-DOTATATE for the treatment of metastatic neuroendocrine tumours [0.03%]
镥-177_DOTATATE治疗转移性神经内分泌肿瘤后患者的家人辐射暴露剂量分析
D Levart,S Wicks,N Heraghty et al.
D Levart et al.
Background: The administration of 177Lu-DOTATATE peptide receptor radionuclide therapy to patients for the treatment of well-differentiated, metastatic neuroendocrine tumours poses an external radiation hazard due to gamm...
Impact of 18F-FDG radioactivity outside the field of view on image quality in a SiPM-based time-of-flight dedicated breast PET scanner: a phantom study [0.03%]
基于SiPM的专用乳腺PET扫描仪视场外18F-FDG放射性对图像质量影响的体模研究
Takuro Shiiba,Hana Katakami,Aiko Naito et al.
Takuro Shiiba et al.
Background: This study aimed to evaluate the impact of F-fluorodeoxyglucose (18F-FDG) uptake outside the field of view on image quality of a silicon photomultiplier tube (SiPM)-based dedicated breast (db) positron emissio...
Quantifying DNA strand breaks from targeted alpha emitters 225Ac and 227Th via Geant4-DNA: implications for RBE and cell survival [0.03%]
Geant4-DNA计算的靶向发射α粒子的225Ac和227Th引起的DNA单链断裂：对射线生物效应和细胞存活的影响
Samaneh Zolghadri,Payman Rafiepour,Hassan Yousefnia
Samaneh Zolghadri
Background: Targeted alpha therapy (TAT) utilizing high-LET alpha particles from radionuclides like 225Ac and 227Th shows promise in cancer treatment due to their ability to induce dense, localized DNA damage. This study ...