Novel vaccines targeting dendritic cells by coupling allergoids to mannan [0.03%]
甘露糖结合变应原多肽疫苗通过靶向树突状细胞治疗过敏性疾病
Cristina Benito-Villalvilla,Irene Soria,José Luis Subiza et al.
Cristina Benito-Villalvilla et al.
Allergen-specific immunotherapy (AIT) is the single disease-modifying treatment for allergy. Clinical trials show AIT to be safe and effective for many patients; however, it still faces problems related to efficacy, safety, long treatment d...
Virus-like particles (VLP) in prophylaxis and immunotherapy of allergic diseases [0.03%]
病毒样颗粒(VLP)在过敏性疾病预防和免疫治疗中的作用
Ludger Klimek,Thomas Kündig,Matthias F Kramer et al.
Ludger Klimek et al.
Background: Apart from active allergen avoidance, immunotherapy is regarded as the most effective form of treatment available for type I allergies. Such treatments involve the administration of allergen preparations in va...
Long-acting muscarinic antagonists for the treatment of asthma in children-a new kid in town [0.03%]
长效毒蕈碱受体拮抗剂用于儿童哮喘治疗的新进展
Eckard Hamelmann
Eckard Hamelmann
Background: Asthma is the most prevalent chronic airway disease observed in children and adolescents, yet the variety of treatment options available for this age group is limited. With many factors influencing therapeutic...
Non-celiac gluten/wheat sensitivity (NCGS)-a currently undefined disorder without validated diagnostic criteria and of unknown prevalence: Position statement of the task force on food allergy of the German Society of Allergology and Clinical Immunology (DGAKI) [0.03%]
非乳糜泻麸质/小麦敏感性（NCGS）-一个目前尚未定义的疾病，没有有效的诊断标准且发病率未知：德国过敏和临床免疫学会食品过敏工作组立场文件
Imke Reese,Christiane Schäfer,Jörg Kleine-Tebbe et al.
Imke Reese et al.
Within the last decade, non-celiac gluten/wheat sensitivity (NCGS) has been increasingly discussed not only in the media but also among medical specialties. The existence and the possible triggers of NCGS are controversial. Three internatio...
SCIT with a high-dose house dust mite allergoid is well tolerated: safety data from pooled clinical trials and more than 10 years of daily practice analyzed in different subgroups [0.03%]
高剂量尘螨过敏疫苗安全耐受：临床试验及十多年的每日实践中的亚组分析安全数据
Ludger Klimek,Gabriele-Cornelia Fox,Susanne Thum-Oltmer
Ludger Klimek
Background: Efficacy of house dust mite (HDM) allergen immunotherapy (AIT) in allergic rhinitis and controlled allergic asthma has been documented in controlled trials with adults and children. However, tolerability compa...
Roy Gerth van Wijk
Roy Gerth van Wijk
Background: Allergen immunotherapy has proven to be efficacious in allergic rhinitis and asthma. However, results from randomised clinical trials may vary substantially. Clinical trials may unexpectedly fail. The purpose ...
Anthony J Frew,Oliver Pfaar
Anthony J Frew
Placebo effects are common in medicine. Randomised clinical trials help us to understand their magnitude in different therapies. There are particular problems with placebo effects in allergen immunotherapy (AIT) as it is difficult to blind ...
Perioperative drug reactions - practical recommendations for allergy testing and patient management [0.03%]
围手术期药物过敏反应——过敏试验及患者管理的实用建议
Wolfgang Pfützner,Knut Brockow
Wolfgang Pfützner
Background: Allergy testing for perioperative drug reactions poses a particular diagnostic challenge. Neuromuscular blocking agents (NMBA) and antibiotics are among the most common triggers. In principle, however, any dru...
NSAID hypersensitivity - recommendations for diagnostic work up and patient management [0.03%]
非甾体抗炎药过敏：诊断和患者管理建议
Stefan Wöhrl
Stefan Wöhrl
Background: Adverse drug reactions (ADR) to analgesics (i.e., non-steroidal anti-inflammatory drug hypersensitivity, NSAID-HS) are one of the most common ADR, affecting approximately 1.6% of all patients. Despite the fact...
Vitamin A and D in allergy: from experimental animal models and cellular studies to human disease [0.03%]
维生素A和D在过敏中的作用：从实验动物模型和细胞研究到人类疾病的研究进展
Karin Hufnagl,Erika Jensen-Jarolim
Karin Hufnagl
Introduction: Vitamins A and D are able to modulate innate and adaptive immune responses and may therefore influence the development and the course of allergic diseases. ...