The Pregnancy Exposome [0.03%]
孕期暴露组学
Oliver Robinson,Martine Vrijheid
Oliver Robinson
The exposome concept takes a holistic approach facilitated by new and emerging technologies to describe 'the totality of human environmental (i.e. non-genetic) exposures from conception onwards, complementing the genome'. It provides a fram...
Effect of Gene-Mercury Interactions on Mercury Toxicokinetics and Neurotoxicity [0.03%]
基因-汞交互作用对汞毒代动力学和神经毒性的效应
Sabrina Llop,Ferran Ballester,Karin Broberg
Sabrina Llop
Individuals differ in susceptibility to mercury neurotoxicity, in part, due to underlying genetic differences. This review aims to evaluate the state-of-the-art of the effect of (1) genetics on mercury toxicokinetics and (2) gene-mercury in...
Stephen Stansfeld,Charlotte Clark
Stephen Stansfeld
Environmental noise exposure, such as road traffic noise and aircraft noise, is associated with a range of health outcomes in children. Children demonstrate annoyance responses to noise, and noise is also related to lower well-being and str...
The Role of the Epigenome in Translating Neighborhood Disadvantage Into Health Disparities [0.03%]
表观基因组在将邻里不利因素转化为健康差异中的作用
Kenneth Olden,Heather A Olden,Yu-Sheng Lin
Kenneth Olden
The possible causal role of the environment in health disparities is not well understood, even though it has been a national priority for many years. Progress to investigate the relationship between genetics, environmental exposures, and he...
E Andres Houseman,Stephanie Kim,Karl T Kelsey et al.
E Andres Houseman et al.
Due to its convenience, the blood is commonly used in epigenomic studies, but its heterogeneous nature leads to interpretation difficulties, given the now widely recognized potential for confounding by cell composition effects. Many recent ...
Arsenic Exposure and Epigenetic Alterations: Recent Findings Based on the Illumina 450K DNA Methylation Array [0.03%]
砷暴露与表观遗传改变：基于Illumina 450K DNA甲基化芯片的最新研究发现
Maria Argos
Maria Argos
Arsenic is a major public health concern worldwide. While it is an established carcinogen and associated with a number of other adverse health outcomes, the molecular mechanisms underlying arsenic toxicity are not completely clarified. Ther...
Select Prenatal Environmental Exposures and Subsequent Alterations of Gene-Specific and Repetitive Element DNA Methylation in Fetal Tissues [0.03%]
选择性宫内环境暴露与胎儿组织特异性基因和重复元件DNA甲基化改变的关系研究
Benjamin B Green,Carmen J Marsit
Benjamin B Green
Strong evidence implicates maternal environmental exposures in contributing to adverse outcomes during pregnancy and later in life through the developmental origins of health and disease hypothesis. Recent research suggests these effects ar...
Christine Ladd-Acosta
Christine Ladd-Acosta
To advance our knowledge of the influence of environmental exposures on human health and disease, robust studies are needed. However, for many exposures, robust studies are not feasible due to limitations with current ascertainment methods ...
Cristina M Villanueva,Sylvaine Cordier,Laia Font-Ribera et al.
Cristina M Villanueva et al.
The presence of chemical compounds formed as disinfection by-products (DBPs) is widespread in developed countries, and virtually whole populations are exposed to these chemicals through ingestion, inhalation, or dermal absorption from drink...
Health Effects of Toxic Cyanobacteria in U.S. Drinking and Recreational Waters: Our Current Understanding and Proposed Direction [0.03%]
美国饮用水和娱乐水中有毒蓝细菌的健康影响：我们的当前理解及建议方向
Timothy G Otten,Hans W Paerl
Timothy G Otten
Cyanobacterial-derived water quality impairment issues are a growing concern worldwide. In addition to their ecological impacts, these organisms are prolific producers of bioactive secondary metabolites, many of which are known human intoxi...