New Tools in Experimental Cellular Therapy for the Treatment of Liver Diseases [0.03%]
实验细胞疗法治疗肝病的新工具
Jennifer R Ferrer,Attasit Chokechanachaisakul,Jason A Wertheim
Jennifer R Ferrer
The current standard of care for end stage liver disease is orthotopic liver transplantation (OLT). Through improvement in surgical techniques, immunosuppression, and general medical care, liver transplantation has become an effective treat...
Jordi Ochando,Patricia Conde,Vincenzo Bronte
Jordi Ochando
Myeloid-derived suppressor cells (MDSC) are cells of myeloid origin with enhanced suppressive function. They are negative regulators of the immune responses and comprise a heterogeneous mixture of immunosuppressive cells of monocytic (M-MDS...
Alexandra James,Roslyn B Mannon
Alexandra James
A solid organ transplant is life-saving therapy that engenders the use of immunosuppressive medications for the lifetime of the transplanted organ and its recipient. Conventional therapy includes both induction therapy (a biologic that is i...
Hypothermic Oxygenated Liver Perfusion: Basic Mechanisms and Clinical Application [0.03%]
超氧化肝脏灌注：基本原理及临床应用
A Schlegel,P Kron,P Dutkowski
A Schlegel
Dynamic preservation strategies such as hypothermic machine perfusion are increasingly discussed to improve liver graft quality before transplantation. This review summarizes current knowledge of this perfusion technique for liver preservat...
Mahboobe Ghaedi,Laura E Niklason,Jordana Williams
Mahboobe Ghaedi
Considerable progress has been made in the field of in vitro development of alveolar epithelium from induced pluripotent stem cells. Patient specific derived alveolar cells could potentially populate tissue engineered lungs, provide a cell ...
R R Redfield,D B Kaufman,J S Odorico
R R Redfield
Despite significant improvement in pancreas allograft survival, rejection of the pancreas remains a major clinical problem. In addition to cellular rejection of the pancreas, antibody-mediated rejection of the pancreas is now a well-describ...
Robotic-assisted Kidney Transplantation: Our Experience and Literature Review [0.03%]
机器人辅助的肾移植：我们的经验和文献回顾
Ivo Tzvetanov,Giuseppe D&#x;Amico,Enrico Benedetti
Ivo Tzvetanov
Kidney transplantation is the preferred treatment for patients with end-stage renal disease. While open surgery remains the gold standard, minimally invasive surgery has recently been introduced for the recipient undergoing kidney transplan...
Cecilia Cabello-Kindelan,Shane Mackey,Allison L Bayer
Cecilia Cabello-Kindelan
There is a clear need to develop strategies to induce tolerance without the need of chronic immunosuppression in transplant recipient and in patients with autoimmunity. Adoptive T regulatory cell (Treg) therapy offers the potential of long-...
Vascularized Composite Allografts: Procurement, Allocation, and Implementation [0.03%]
血管化复合异体移植：获取、分配与实施
Axel Rahmel
Axel Rahmel
Vascularized composite allotransplantation is a continuously evolving area of modern transplant medicine. Recently, vascularized composite allografts (VCAs) have been formally classified as 'organs'. In this review, key aspects of VCA procu...
T Follicular Helper Cells in Transplantation: The Target to Attenuate Antibody-Mediated Allogeneic Responses? [0.03%]
移植中的滤泡辅助T细胞：抑制抗体介导的同种异体反应的目标？
Carla C Baan,Gretchen N de Graav,Karin Boer
Carla C Baan
Antibody-mediated, humoral rejection has been recognized as a common cause of transplant dysfunction and is responsible for 30-50 % of failed allografts. The production of antibody is dependent on instructions from memory CD4+ T helper cell...