Gene Editing, Gene Therapy, and Cell Xenotransplantation: Cell Transplantation Across Species [0.03%]
基因编辑、基因治疗和异种细胞移植：跨物种的细胞移植
Nizar I Mourad,Pierre Gianello
Nizar I Mourad
Purpose of review: Cell xenotransplantation has the potential to provide a safe, ethically acceptable, unlimited source for cell replacement therapies. This review focuses on genetic modification strategies aimed to overc...
Hepatocyte Transplantation: Cell Sheet Technology for Liver Cell Transplantation [0.03%]
肝细胞移植：肝细胞移植的细胞片技术
Kohei Tatsumi,Teruo Okano
Kohei Tatsumi
Purpose of review: We will review the recent developments of cell sheet technology as a feasible tissue engineering approach. Specifically, we will focus on the technological advancement for engineering functional liver t...
Yianzhu Liu,Malgorzata Kloc,Xian C Li
Yianzhu Liu
Organ transplants give a second chance of life to patients with end-stage organ failure. However, the immuno-logical barriers prove to be very challenging to overcome and graft rejection remains a major hurdle to long-term transplant surviv...
Adoptive Cell Therapy with Tregs to Improve Transplant Outcomes: The Promise and the Stumbling Blocks [0.03%]
调节性T细胞过继免疫治疗改善移植预后的希望与挑战
Mohamed B Ezzelarab,Angus W Thomson
Mohamed B Ezzelarab
The contribution of regulatory T cells (Treg) to the induction and maintenance of tolerance is well-recognized in rodents and may contribute to long-term human organ allograft survival. The therapeutic efficacy of adoptively-transferred Tre...
Luciano De Carlis,Stefano Di Sandro,Leonardo Centonze et al.
Luciano De Carlis et al.
The main goal of organ allocation systems is to guarantee an equal access to the limited resource of liver grafts for every patients on the waiting list, balancing between the ethical principles of equity, utility, benefit, need, and fairne...
Christian Schuetz,James F Markmann
Christian Schuetz
In the last 15 years clinical islet transplantation has made the leap from experimental procedure to standard of care for a highly selective group of patients. Due to a risk-benefit calculation involving the required systemic immunosuppress...
Antibodies to HLA Molecules Mimic Agonistic Stimulation to Trigger Vascular Cell Changes and Induce Allograft Injury [0.03%]
补体结合的HLA抗体通过模仿激动剂刺激诱导移植物血管病和血管细胞损伤
Nicole M Valenzuela,Elaine F Reed
Nicole M Valenzuela
Human leukocyte antigen (HLA)-induced signaling in endothelial and smooth muscle cells causes dramatic cytoskeletal rearrangement, increased survival, motility, proliferation, adhesion molecule and chemokine expression, and adhesion of leuk...
Jason M Gauthier,Ramsey R Hachem,Daniel Kreisel
Jason M Gauthier
Chronic lung allograft dysfunction (CLAD) encompasses a range of pathologies that cause a transplanted lung to not achieve or maintain normal function. CLAD manifests as airflow restriction and/or obstruction and is predominantly a result o...
Ryan D Sochol,Navin R Gupta,Joseph V Bonventre
Ryan D Sochol
The advancement of "kidney-on-a-chip" platforms - submillimeter-scale fluidic systems designed to recapitulate renal functions in vitro - directly impacts a wide range of biomedical fields, including drug screening, cell and tissue engineer...
Tomas Castro-Dopico,Menna R Clatworthy
Tomas Castro-Dopico
In the current era, one of the major factors limiting graft survival is chronic antibody-mediated rejection (ABMR), whilst patient survival is impacted by the effects of immunosuppression on susceptibility to infection, malignancy and ather...