Combining Adoptive Treg Transfer with Bone Marrow Transplantation for Transplantation Tolerance [0.03%]
调控型T细胞联合骨髓移植诱导移植耐受
Nina Pilat,Nicolas Granofszky,Thomas Wekerle
Nina Pilat
Purpose of review: The mixed chimerism approach is an exceptionally potent strategy for the induction of donor-specific tolerance in organ transplantation and so far the only one that was demonstrated to work in the clini...
Harnessing Apoptotic Cells for Transplantation Tolerance: Current Status and Future Perspectives [0.03%]
凋亡细胞在移植耐受中的作用及其研究进展
Anil Dangi,Xunrong Luo
Anil Dangi
Purpose of review: The use of donor apoptotic cells is an emerging therapy for inducing transplantation tolerance. In this review, we will discuss current understanding of mechanisms of this approach, as well as crucial a...
William S Oetting,Casey Dorr,Rory P Remmel et al.
William S Oetting et al.
Purpose of review: Identification of genetic variants to aid in individualized treatment of solid organ allograft recipients would improve graft survival. We will review the current state of knowledge for associations of ...
Negin Karimian,Heidi Yeh
Negin Karimian
Purpose of review: There is a vast discrepancy between the number of patients waiting for organ transplantation and the available donor organs. Ex vivo machine perfusion (MP) has emerged in an effort to expand the donor p...
Nanotechnological Approaches to Immunosuppression and Tolerance Induction [0.03%]
纳米技术在免疫抑制和耐受诱导中的应用
Kunal Patel,Carl Atkinson,Danh Tran et al.
Kunal Patel et al.
Purpose of review: Several preclinical studies have engineered nanoparticles for immune regulation, and have shown promising results in the fields of autoimmunity and cancer. In solid organ transplantation, the use of nan...
Vrushali V Agashe,William J Burlingham
Vrushali V Agashe
Organ transplantation is the only viable treatment for several end-stage organ failures. However chronic rejection prevents long-term graft survival. Traditionally this rejection was attributed to the development of alloimmunity in transpla...
Jennifer C Gander,Elisa J Gordon,Rachel E Patzer
Jennifer C Gander
Purpose of review: For the more than 636,000 adults with end-stage renal disease (ESRD) in the U.S., kidney transplantation is the preferred treatment compared to dialysis. Living donor kidney transplantation (LDKT) compr...
Xenotransplantation: Where Are We with Potential Kidney Recipients? Recent Progress and Potential Future Clinical Trials [0.03%]
异种移植：潜在的肾脏受者的现状近期进展和未来临床试验的潜力
Kazuhiko Yamada,Jigesh A Shah,Tatsu Tanabe et al.
Kazuhiko Yamada et al.
Purpose: Inter-species transplantation, xenotransplantation, is becoming a realistic strategy to solve the organ shortage crisis. Here we focus on seminal publications that have driven research in xenotransplantation, as ...
Measuring transplant center performance: The goals are not controversial but the methods and consequences can be [0.03%]
移植中心绩效评估：目标无争议 方法和结果有争议
Colleen Jay,Jesse D Schold
Colleen Jay
Purpose of review: Risks of regulatory scrutiny has generated widespread concern about increasingly risk averse transplant center behaviors regarding both donor and candidate acceptance patterns. To address potential unin...
Wayne M Tsuang
Wayne M Tsuang
Purpose of review: To discuss the current state of donor lung allocation in the United States, and future opportunities to increase the efficiency of donor lung allocation. ...