James E Squires,Kyle A Soltys,Patrick McKiernan et al.
James E Squires et al.
Purpose of review: Significant recent scientific developments have occurred in the field of liver repopulation and regeneration. While techniques to facilitate liver repopulation with donor hepatocytes and different cell ...
Carlo D L Ceresa,David Nasralla,Wayel Jassem
Carlo D L Ceresa
Purpose of review: This review aims to introduce the concept of normothermic machine perfusion (NMP) and its role in liver transplantation. By discussing results from recent clinical studies and highlighting the potential...
Andrea Schlegel,Xavier Muller,Philipp Dutkowski
Andrea Schlegel
Purpose of review: In this review, we highlight which livers may benefit from additional treatment before implantation and describe the concept of hypothermic machine liver perfusion. Furthermore, we explain why cold oxyg...
From "Gut Feeling" to Objectivity: Machine Preservation of the Liver as a Tool to Assess Organ Viability [0.03%]
从"直觉"到客观性：利用机器保存肝脏以评估器官活力
Christopher J E Watson,Ina Jochmans
Christopher J E Watson
Purpose of review: The purpose of this review was to summarise how machine perfusion could contribute to viability assessment of donor livers. Recent find...
Elena Garreta,Sonia Sanchez,Jeronimo Lajara et al.
Elena Garreta et al.
Purpose of review: The goal of this paper is to highlight the major challenges in the translation of human pluripotent stem cells into a clinical setting. ...
Simultaneous Liver-Kidney Transplantation: Impact on Liver Transplant Patients and the Kidney Transplant Waiting List [0.03%]
肝肾联合移植：对肝移植受者和肾脏移植等待名单的影响
Clifford D Miles,Scott Westphal,AnnMarie Liapakis et al.
Clifford D Miles et al.
Purpose: The number of simultaneous liver-kidney transplants (SLKT) performed in the USA has been rising. The Organ Procurement and Transplantation Network implemented a new policy governing SLKT that specifies eligibilit...
Vasishta S Tatapudi,Robert A Montgomery
Vasishta S Tatapudi
Purpose of review: Over the past two decades, significant strides made in our understanding of the etiology of antibody-mediated rejection (AMR) in transplantation have put the complement system in the spotlight. Here, we...
Donation, Not Disease! A Multiple-Hit Hypothesis on Development of Post-Donation Kidney Disease [0.03%]
捐献而非疾病！关于捐后肾脏疾病的多因素假设
Xingxing S Cheng,Richard J Glassock,Krista L Lentine et al.
Xingxing S Cheng et al.
Purpose of review: The risks following living kidney donation has been the subject of rigorous investigation in the past several decades. How to utilize the burgeoning new knowledge base to better the risk assessment, edu...
Combining Adoptive Treg Transfer with Bone Marrow Transplantation for Transplantation Tolerance [0.03%]
调控型T细胞联合骨髓移植诱导移植耐受
Nina Pilat,Nicolas Granofszky,Thomas Wekerle
Nina Pilat
Purpose of review: The mixed chimerism approach is an exceptionally potent strategy for the induction of donor-specific tolerance in organ transplantation and so far the only one that was demonstrated to work in the clini...
Harnessing Apoptotic Cells for Transplantation Tolerance: Current Status and Future Perspectives [0.03%]
凋亡细胞在移植耐受中的作用及其研究进展
Anil Dangi,Xunrong Luo
Anil Dangi
Purpose of review: The use of donor apoptotic cells is an emerging therapy for inducing transplantation tolerance. In this review, we will discuss current understanding of mechanisms of this approach, as well as crucial a...