CRISPR as agent: a metaphor that rhetorically inhibits the prospects for responsible research [0.03%]
作为代理的CRISPR：一个限制责任研究前景的修辞隐喻
Leah Ceccarelli
Leah Ceccarelli
In 2015, a group of 18 scientists and bioethicists published an editorial in Science calling for "open discourse on the use of CRISPR-Cas9 technology to manipulate the human genome" and recommending that steps be taken to strongly discourag...
Understanding the emotion of shame in transgender individuals - some insight from Kafka [0.03%]
理解跨性别者的羞耻感——从卡夫卡的作品中获得的一些启示
Simona Giordano
Simona Giordano
Both clinical literature and biographical accounts suggest that many transgender individuals experience shame or have experienced shame at some point in their life for reasons related to their gender identity. In clinical psychology, at lea...
How to do things with metaphors: engineering life as hodgepodge [0.03%]
修辞立其诚——工程生命为什锦集粹式的生命合成伦理的建构与反思
Matthew Kearnes,Declan Kuch,Angus Johnston
Matthew Kearnes
This paper presents a collaboration between social scientists and a chemist exploring the promises for new therapy development at the intersection between synthetic biology and nanotechnology. Drawing from ethnographic studies of laboratori...
Constructing future scenarios as a tool to foster responsible research and innovation among future synthetic biologists [0.03%]
构建未来场景以促进合成生物学家的责任研究和创新
Afke Wieke Betten,Virgil Rerimassie,Jacqueline E W Broerse et al.
Afke Wieke Betten et al.
The emerging field of synthetic biology, the (re-)designing and construction of biological parts, devices and systems for useful purposes, may simultaneously resolve some issues and raise others. In order to develop applications robustly an...
The governance structure for data access in the DIRECT consortium: an innovative medicines initiative (IMI) project [0.03%]
直接联盟的数据访问治理结构：一个创新药物倡议（IMI）项目
Harriet J A Teare,Federico de Masi,Karina Banasik et al.
Harriet J A Teare et al.
Biomedical research projects involving multiple partners from public and private sectors require coherent internal governance mechanisms to engender good working relationships. The DIRECT project is an example of such a venture, funded by t...
Manuel Porcar,Juli Peretó
Manuel Porcar
Synthetic biology is the engineering view on biotechnology that ultimately aims at fulfilling the quest of building an artificial cell. From the very first attempts of synthesizing life, this subject has made an impact on the media through,...
Evolutionary tinkering vs. rational engineering in the times of synthetic biology [0.03%]
合成生物学时代下的进化改良与理性工程学
Víctor de Lorenzo
Víctor de Lorenzo
Synthetic biology is not only a contemporary reformulation of the recombinant DNA technologies of the last 30 years, combined with descriptive language imported from electrical and industrial engineering. It is also a new way to interpret l...
Clinical exome sequencing in France and Quebec: what are the challenges? What does the future hold? [0.03%]
法国和魁北克的临床外显子测序面临哪些挑战？未来会怎样？
Gabrielle Bertier,Yann Joly
Gabrielle Bertier
Background: The decreasing cost of next-generation sequencing technologies (NGS) has resulted in their increased use in research, and in the clinic. However, France and Quebec have not yet implemented nation-wide personal...
Who are the users of synthetic DNA? Using metaphors to activate microorganisms at the center of synthetic biology [0.03%]
合成DNA的使用者都有谁？用隐喻激活合成生物学核心的微生物
Erika Amethyst Szymanski
Erika Amethyst Szymanski
Synthetic biology, a multidisciplinary field involving designing and building with DNA, often designs and builds in microorganisms. The role of these microorganisms tends to be understood through metaphors making the microbial cell like a m...
Disease surveillance data sharing for public health: the next ethical frontiers [0.03%]
公共卫生传染病监控数据共享的伦理问题——下一个伦理前沿
Patty Kostkova
Patty Kostkova
In the recent years, we have been witnessing a digital revolution in public and global health creating unprecedented opportunities for epidemic intelligence and public health emergencies. However, these opportunities created a double edge s...