Comparative proteomic analysis of cerebrospinal fluid and brain tissue using Orbitrap Astral and timsTOF Pro 2 platforms with data-independent acquisition [0.03%]
基于轨道离子阱Astral和timsTOF Pro 2平台数据非依赖型采集的脑脊液和脑组织比较蛋白质组学分析
Miyo K Chatanaka,Maria Pascual Lorén,Cassandra J Wong et al.
Miyo K Chatanaka et al.
Objectives: Cerebrospinal fluid (CSF) contains thousands of proteins, and some of them are useful biomarkers for brain diseases, including neurodegeneration. Our objective was to compare two state-of-the-art mass spectrom...
Balancing benefit, harm, and uncertainty in diagnosis: determining the testing threshold in clinical practice [0.03%]
诊断中的利弊与不确定性评估：确定临床实践中的检验门槛
Erin H Yang,Zaven Sargsyan,Prathit A Kulkarni
Erin H Yang
Decision making related to diagnostic testing is central to the daily practice of clinical medicine. The decision to obtain or defer certain diagnostic testing can be straightforward in some cases but more nuanced in others. Explicit use of...
Diagnostic uncertainty as a public health imperative: a call for R69 code adoption [0.03%]
关于采纳R69代码以应对诊断不确定性这一公共卫生要求的呼吁
Helen W Hernandez,Helene M Epstein,Mohamed Zahir Alimohamed et al.
Helen W Hernandez et al.
Failure of the Galleri multi-cancer detection trial to meet its primary endpoint [0.03%]
Galleri多癌症检测试验主要终点分析未达到预期结果
Eleftherios P Diamandis
Eleftherios P Diamandis
Cancer screening has been at the forefront of the war against cancer for decades. Yet professional organizations such as the U.S. Preventive Services Task Force (USPSTF) recommend cancer screening for only a handful of cancers (cervical, lu...
Identification and analysis of the evidence gaps in the field of diagnostic errors research in Japan: a scoping review [0.03%]
日本诊断错误研究领域的证据缺口识别与分析：系统综述
Kotaro Kunitomo,Yukinori Harada,Tomoharu Suzuki et al.
Kotaro Kunitomo et al.
Objectives: This scoping review aimed to identify and map the existing evidence for the status of diagnostic errors in adult patients in Japan. Methods: ...
Toshiki Nakamura,Reo Uegaki,Takahiro Suzuki et al.
Toshiki Nakamura et al.
The Diagnostic Efficiency Ratio (DER): conceptual rationale, mathematical derivation, and hypothetical evaluation of a prevalence-sensitive benefit-harm metric [0.03%]
诊断效率比（DER）：概念论理，数学推导及一种敏感流行病学优势-危害衡量标准的假设评估
Matthew L Rubinstein
Matthew L Rubinstein
Objectives: Traditional diagnostic accuracy metrics - sensitivity, specificity, predictive values, likelihood ratios, and global indices such as Youden's J and the diagnostic odds ratio - describe important statistical pr...
A new perspective: blending ecological psychology and Safety II to learn from diagnostic excellence [0.03%]
新视角：融合生态心理学和Safety II的学习诊断优秀经验
Jonathan G Sawicki,Russell Leslie,Daniel Nystrom
Jonathan G Sawicki
Objectives: Traditional safety frameworks applied in isolation have been insufficient to address the problem of diagnostic error in healthcare. We created a novel blend of approaches - leveraging Safety II and ecological ...
Lakshmi Krishnan,Christine Cassel
Lakshmi Krishnan
The integration of artificial intelligence into clinical practice demands fundamental reconsideration of how we conceptualize diagnosis. Clinical and popular discourse often frames diagnosis as a "virtuoso model" emphasizing individual phys...
Comparison of AI, diagnostic generator, and expert opinion in difficult neurologic diagnosis: real-world case study [0.03%]
人工智能、诊断生成器和专家意见在神经疑难病诊断中的比较：真实世界病例研究
Pasquale F Finelli
Pasquale F Finelli
Objectives: Comparative diagnosis of AI vs. diagnostic generator and expert opinion in complex neurologic cases is limited. We present the results of a comparative study of these three diagnostic methods. ...