Jesse Ling,Clay S Bennett
Jesse Ling
Because of their pivotal biological functions, attention to sugars and glycobiology has grown rapidly in recent decades, leading to increased demand for homogeneous oligosaccharides. The stereoselective preparation of oligosaccharides by ch...
Ajay L Chandgude,Jingyao Li,Alexander Dömling
Ajay L Chandgude
2-Nitrobenzyl isocyanide is reported as a universal convertible isocyanide with extensive applicability in both Ugi four-component reaction (Ugi-4CR) and Ugi-tetrazole reaction. The cleavage of this isocyanide from 17 examples in both acidi...
Lukas Roiser,Katharina Zielke,Mario Waser
Lukas Roiser
The use of readily accessible ammonium ylides for (asymmetric) transformations, especially cyclization reactions, has received considerable attention over the past two decades. A variety of highly enantioselective protocols to facilitate an...
Syntheses of Highly Functionalized Spirocyclohexenes by Formal [4+2] Annulation of Arylidene Azlactones with Allenoates [0.03%]
通过 arylenes azlactones 和 allenoates 的 [4+2]环加成反应合成高度官能化的 spirocyclohexenes
Andreas Eitzinger,Katharina Zielke,Michael Widhalm et al.
Andreas Eitzinger et al.
A straightforward phosphine-catalyzed formal [4+2] annulation between α-branched allenoates and arylidene azlactones has been developed to access highly functionalized spirocyclohexenes. This cyclization favors the γ-addition of the phosp...
Recent Developments in Pd(0)-Catalyzed Alkene Carboheterofunctionalization Reactions [0.03%]
近年来钯(0)催化烯烃卡宾杂化官能团化反应的研究进展
Zachary J Garlets,Derick R White,John P Wolfe
Zachary J Garlets
This review summarizes recent developments in palladium-catalyzed alkene carboalkoxylation and carboamination reactions. New synthetic methods that have been reported in the past four years are described, along with mechanistic issues and t...
Kimberly S Petersen
Kimberly S Petersen
The synthesis of enantioenriched small molecules is an ongoing goal of organic chemists. This focus review explores the use of kinetic resolutions catalyzed by chiral Brønsted acids. Methods include classic kinetic resolutions and dynamic ...
San Khong,Ohyun Kwon
San Khong
Phosphinocatalysis provides a new approach toward 3-substituted-4-quinolones. A simple procedure, which uses Ph3P as an inexpensive catalyst and S-phenyl 2-(N-tosylamido)benzothioates and activated alkynes as starting materials, provides di...
Rapid Construction of (-)-Paroxetine and (-)-Femoxetine via N-Heterocyclic Carbene Catalyzed Homoenolate Addition to Nitroalkenes [0.03%]
新型N-杂环卡宾催化硝基烯烃与 enamino 酯的对映选择性加成反应及其在抗抑郁药物（-）帕罗西汀和（-）伏硫西汀合成中的应用研究
Nicholas A White,Kerem E Ozboya,Darrin M Flanigan et al.
Nicholas A White et al.
A concise enantioselective synthesis of (-)-paroxetine (Paxil) and (-)-femoxetine has been achieved. Key to these syntheses is a N-heterocyclic carbene catalyzed homoenolate addition to a nitroalkene followed by in situ reduction of the nit...