An integrative docking and simulation-based approach towards the development of epitope-based vaccine against enterotoxigenic Escherichia coli [0.03%]
基于对接和模拟的整合方法开发针对产肠毒素大肠杆菌的抗原表位疫苗
Fariya Khan,Ajay Kumar
Fariya Khan
Enterotoxigenic E.coli is causing diarrheal illness in children as well as adults with the majority of the cases occurring in developing countries. To reduce the number of cases occurring worldwide, the development of an effectual vaccine a...
Exploring the active constituents of Oroxylum indicum in intervention of novel coronavirus (COVID-19) based on molecular docking method [0.03%]
基于分子对接方法探索预证的碱式树活性成分干预新型冠状病毒（COVID-19）肺炎的有效成分研究
Sapan Shah,Dinesh Chaple,Sumit Arora et al.
Sapan Shah et al.
The severe acute respiratory syndrome COVID-19 declared a global pandemic by WHO has become the present wellbeing worry to the whole world. There is an emergent need to search for possible medications. We report in this study a molecular do...
Louie Florendo Dy,Jomar Fajardo Rabajante
Louie Florendo Dy
The number of confirmed COVID-19 cases admitted in hospitals is continuously increasing in the Philippines. Frontline health care workers are faced with imminent risks of getting infected. In this study, we formulate a theoretical model to ...
Molecular docking suggests repurposing of brincidofovir as a potential drug targeting SARS-CoV-2 ACE2 receptor and main protease [0.03%]
分子对接提示brincidofovir作为一种潜在药物用于靶向SARS-CoV-2 ACE2受体和主蛋白酶的再利用可能性
Mostafa A Hussien,Ahmed E M Abdelaziz
Mostafa A Hussien
Abstract: The current outbreak of the highly transmittable and life-threatening severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved rapidly and posed a global health emergency. Many clinical trials ar...
Shilpa Shiragannavar,Shivakumar Madagi,Joy Hosakeri et al.
Shilpa Shiragannavar et al.
Chlamydia trachomatis, a gram-negative bacterium known to infect the genital sites mainly columnar epithelial cells of the cervix, urethra and rectum in women and causes acute epididymitis, urinary tract inflammation and DNA damage to the s...
A new insight into identification of in silico analysis of natural compounds targeting GPR120 [0.03%]
针对GPR120靶点的天然产物化学信息识别的新见解
Nagaraju Chinthakunta,Srinivasulu Cheemanapalli,Surekha Chinthakunta et al.
Nagaraju Chinthakunta et al.
G-protein coupled receptor (GPR120) is an omega-3 fatty acid receptor that inhibits macrophage-induced tissue inflammation. Recent studies revealed GPR120 promotes colorectal carcinoma through modulation of VEGF, IL-8, PGE2, and NF-kB expre...
Employing the Gini coefficient to measure participation inequality in treatment-focused Digital Health Social Networks [0.03%]
运用基尼系数衡量以治疗为核心的数字健康社交网络中的参与不平等现象
Trevor van Mierlo,Douglas Hyatt,Andrew T Ching
Trevor van Mierlo
Digital Health Social Networks (DHSNs) are common; however, there are few metrics that can be used to identify participation inequality. The objective of this study was to investigate whether the Gini coefficient, an economic measure of sta...
Implementation and comparison of kernel-based learning methods to predict metabolic networks [0.03%]
基于核方法的学习算法在代谢网络预测中的实现及比较研究
Abiel Roche-Lima
Abiel Roche-Lima
Metabolic pathways can be conceptualized as the biological equivalent of a data pipeline. In living cells, series of chemical reactions are carried out by different proteins called enzymes in a stepwise manner. However, many pathways remain...
Towards Evaluating and Enhancing the Reach of Online Health Forums for Smoking Cessation [0.03%]
增进并评估戒烟线上论坛影响力的评价及增强方法研究
Michael Stearns,Siddhartha Nambiar,Alexander Nikolaev et al.
Michael Stearns et al.
Online pro-health social networks facilitating smoking cessation through web-assisted interventions have flourished in the past decade. In order to properly evaluate and increase the impact of this form of treatment on society, one needs to...
Exploiting Thread-Level and Instruction-Level Parallelism to Cluster Mass Spectrometry Data using Multicore Architectures [0.03%]
利用多核体系结构并行处理思路及指令以聚类质谱数据
Fahad Saeed,Jason D Hoffert,Trairak Pisitkun et al.
Fahad Saeed et al.
Modern mass spectrometers can produce large numbers of peptide spectra from complex biological samples in a short time. A substantial amount of redundancy is observed in these data sets from peptides that may get selected multiple times in ...