Tiago Rodrigues
Tiago Rodrigues
Natural products have long played a leading role as direct source of drugs or as a means to inspire informed molecular design. Indeed, natural products have been biologically prevalidated as protein-binding motifs by millions of years of ev...
Resources for Chemical, Biological, and Structural Data on Natural Products [0.03%]
天然产物的化学、生物和结构数据资源
Ya Chen,Christina de Bruyn Kops,Johannes Kirchmair
Ya Chen
Natural products from plants, marine life, animals, fungi, bacteria, and other organisms remain the most productive source of inspiration for small-molecule drug discovery. Today, a wealth of information on natural products that is particul...
Fernando D Prieto-Martínez,Ulf Norinder,José L Medina-Franco
Fernando D Prieto-Martínez
The chemistry of natural products is fascinating and has continuously attracted the attention of the scientific community for many reasons including, but not limited to, biosynthesis pathways, chemical diversity, the source of bioactive com...
Secondary Metabolites of Endophytic Actinomycetes: Isolation, Synthesis, Biosynthesis, and Biological Activities [0.03%]
内生放线菌次级代谢产物的研究：分离、合成、生物合成及其生物活性
Darlon Irineu Bernardi,Fernanda Oliveira das Chagas,Afif Felix Monteiro et al.
Darlon Irineu Bernardi et al.
Endophytic Actinobacteria are a microbial group that is still poorly investigated. Their association with plants constitutes a unique trait conferring specific biological and chemical features to endophytic Actinobacteria. This contribution...
Serena Fiorito,Francesco Epifano,Francesca Preziuso et al.
Serena Fiorito et al.
Oxyprenylated secondary metabolites (e.g. phenylpropanoids and polyketides) represent a rare class of natural compounds. Over the past two decades, this group of phytochemicals has become a topic of intense research activity by several team...
Rachel Mata,Mario Figueroa,Andrés Navarrete et al.
Rachel Mata et al.
Herbal medicines are an integral element of alternative medical care in Mexico, and the best testimony to their efficacy and cultural value is their persistence in contemporary Mexican marketplaces where the highest percentages of medicinal...
Runner R T Majinda
Runner R T Majinda
The period of the past 5 years has witnessed a remarkable increase in all of the number, structural variety, and complexity of erythrinan alkaloids reported. This structural diversity seems to be most pronounced in the alkaloids reported fr...
Joshua M Henkin,Yulin Ren,Djaja Djendoel Soejarto et al.
Joshua M Henkin et al.
Many of the clinically used anticancer agents in Western medicine are derived from secondary metabolites found in terrestrial microbes, marine organisms, and higher plants, with additional compounds of this type being currently in clinical ...
Satyajit D Sarker,Lutfun Nahar
Satyajit D Sarker
Coumarins are the largest group of 1-benzopyran derivatives found in plants. The initial member of this group of compounds, coumarin (2H-1-benzopyran-2-one), a fragrant colorless compound, was first isolated from the Tonka bean (Dipteryx od...
Human Deiminases: Isoforms, Substrate Specificities, Kinetics, and Detection [0.03%]
人类的去甲基天冬氨酰化酶：同工酶、底物特异性、动力学和检测方法
Bushra Amin,Wolfgang Voelter
Bushra Amin
Peptidylarginine deiminase (PAD) enzymes are of enormous interest in biomedicine. They catalyze the conversion of a positively-charged guanidinium at an arginine side chain into a neutral ureido group. As a result of this conversion, protei...