Sesterterpenoids [0.03%]
四倍半萜类化合物
Takaaki Mitsuhashi,Ikuro Abe
Takaaki Mitsuhashi
Sesterterpenoids are known as a relatively small group of natural products. However, they represent a variety of simple to more complex structural types. This contribution focuses on the chemical structures of sesterterpenoids and how their...
Natalia Blicharska,Veronique Seidel
Natalia Blicharska
Natural remedies have for centuries played a significant role in traditional medicine and continue to be a unique reservoir of new chemical entities in drug discovery and development research. Propolis is a natural substance, collected by b...
Hideyuki Shigemori
Hideyuki Shigemori
Since higher plants are unable to move in their environment, interesting and mysterious developmental events (allelopathy, phototropism, apical dominance, nyctinasty, flowering, senescence) are observed in their life cycle. Chemical compoun...
Edda Gössinger
Edda Gössinger
Isolation, structure determination, synthesis, and biochemistry of the low-molecular-weight compounds of the secretion of exocrine glands of termites are described, with an emphasis on pheromones and defensive compounds. ...
A Strength-Weaknesses-Opportunities-Threats (SWOT) Analysis of Cheminformatics in Natural Product Research [0.03%]
天然产物研究中化学信息学的优缺点分析（SWOT）
Benjamin Kirchweger,Judith M Rollinger
Benjamin Kirchweger
Cheminformatics-based techniques, such as molecular modeling, docking, virtual screening, and machine learning, are well accepted for their usefulness in drug discovery and development of therapeutically relevant small molecules. Although d...
Open-Access Activity Prediction Tools for Natural Products. Case Study: hERG Blockers [0.03%]
天然产物的开放访问活性预测工具。以hERG阻滞剂为例
Fabian Mayr,Christian Vieider,Veronika Temml et al.
Fabian Mayr et al.
Interference with the hERG potassium ion channel may cause cardiac arrhythmia and can even lead to death. Over the last few decades, several drugs, already on the market, and many more investigational drugs in various development stages, ha...
Daniel Reker
Daniel Reker
Fragment-like natural products play a pivotal role in natural product research given their improved synthetic and computational tractability as well as commercial availability compared to more complex natural product structures. A multitude...
The Pharmacophore Concept and Its Applications in Computer-Aided Drug Design [0.03%]
药效团概念及其在计算机辅助药物设计中的应用
Thomas Seidel,Doris A Schuetz,Arthur Garon et al.
Thomas Seidel et al.
Pharmacophore-based techniques currently are an integral part of many computer-aided drug design workflows and have been successfully and extensively applied for tasks such as virtual screening, de novo design, and lead optimization. Pharma...
Tiago Rodrigues
Tiago Rodrigues
Natural products have long played a leading role as direct source of drugs or as a means to inspire informed molecular design. Indeed, natural products have been biologically prevalidated as protein-binding motifs by millions of years of ev...
Resources for Chemical, Biological, and Structural Data on Natural Products [0.03%]
天然产物的化学、生物和结构数据资源
Ya Chen,Christina de Bruyn Kops,Johannes Kirchmair
Ya Chen
Natural products from plants, marine life, animals, fungi, bacteria, and other organisms remain the most productive source of inspiration for small-molecule drug discovery. Today, a wealth of information on natural products that is particul...