Antileishmanial Activity of Lignans, Neolignans, and Other Plant Phenols [0.03%]
植物酚的抗利什曼病活性：木脂素、 neo-木脂素及其他植物酚类
Jiří Pospíšil,Daniela Konrádová,Miroslav Strnad
Jiří Pospíšil
Secondary metabolites (SM) from organisms have served medicinal chemists over the past two centuries as an almost inexhaustible pool of new drugs, drug-like skeletons, and chemical probes that have been used in the "hunt" for new biological...
From Plant to Patient: Thapsigargin, a Tool for Understanding Natural Product Chemistry, Total Syntheses, Biosynthesis, Taxonomy, ATPases, Cell Death, and Drug Development [0.03%]
从植物到患者——噻巴苷：理解天然产物化学、全合成、生物合成、分类学、ATP酶、细胞死亡和药物开发的工具
Søren Brøgger Christensen,Henrik Toft Simonsen,Nikolai Engedal et al.
Søren Brøgger Christensen et al.
Thapsigargin, the first representative of the hexaoxygenated guaianolides, was isolated 40 years ago in order to understand the skin-irritant principles of the resin of the umbelliferous plant Thapsia garganica. The pronounced cytotoxicity ...
The Role of Total Synthesis in Structure Revision and Elucidation of Decanolides (Nonanolides) [0.03%]
全合成在脱氧苦素（诺氧苦素）结构修订和阐明中的作用
Bernd Schmidt
Bernd Schmidt
Ten-membered lactones are commonly observed structures of natural products. They are mostly fungal metabolites, which often act as plant pathogens, but recently ten-membered lactones were identified as pheromones of frogs and termites. Alth...
Yingjie Bai,Liyun Zhang,Xiaoguang Lei
Yingjie Bai
Natural products are a class of chemical compounds that are biosynthesized by living organisms, including humans. Endogenous natural products are produced by human cells as well as by the human microbiome. This contribution describes the cu...
Julio C Pardo-Novoa,Carlos M Cerda-García-Rojas
Julio C Pardo-Novoa
The most significant new techniques that have been used in the twenty-first century for the structure elucidation of sesquiterpenes and some derivatives are reviewed in this chapter. A distinctive feature of these methodologies is the combi...
Nwet Nwet Win,Hiroyuki Morita
Nwet Nwet Win
Myanmar is a country with rich natural resources and of these, medicinal plants play a vital role in the primary health care of its population. The people of Myanmar have used their own system of traditional medicine inclusive of the use of...
Hucheng Zhu,Chunmei Chen,Qingyi Tong et al.
Hucheng Zhu et al.
Cytochalasans are a group of fungal-derived natural products characterized by a perhydro-isoindolone core fused with a macrocyclic ring, and they exhibit a high structural diversity and a broad spectrum of bioactivities. Cytochalasans have ...
Chemical Constituents of Ligularia Species (Asteraceae) and Their Diversity in East Asia [0.03%]
黄花属（菊科）化学成分及东亚地区的多样性分布研究进展
Motoo Tori,Chiaki Kuroda
Motoo Tori
More than 100 Ligularia species and those of several related genera (Cremanthodium, Cacalia, Senecio, and others) in the plant family Senecioneae grow in East Asia. For many years, researchers have studied the chemical constituents of these...
Samantha S Yee,Lin Du,April L Risinger
Samantha S Yee
Microtubule stabilizers are a mainstay in the treatment of many solid cancers and continue to find utility in combination therapy with molecularly targeted anticancer agents and immunotherapeutics. However, innate and acquired resistance to...
Chuan-Yun Xiao,Qing Mu,Simon Gibbons
Chuan-Yun Xiao
Hypericum L. is a genus of the family Hypericaceae within the dicotyledones. The constituents of Hypericum species are valued for their important biological properties. Their use is in the treatment of depression and as antibacterial agents...