Personalized antiplatelet therapy: are we ready for a precision medicine approach [0.03%]
个性化抗血小板治疗：我们准备好采用精准医疗的方法了吗？
Sai Praneeth Chaparala,Abhishek Hanumanpratap Singh Kshatri,Amritha Suresh et al.
Sai Praneeth Chaparala et al.
Dual antiplatelet therapy (DAPT), combining aspirin with a P2Y12 inhibitor, remains central to secondary prevention after acute coronary syndrome and percutaneous coronary intervention. However, substantial interindividual variability in an...
Predicting COVID-19 severity using machine learning: the role of clinical parameters, blood groups, and vaccination status across age groups [0.03%]
基于机器学习预测COVID-19的严重程度：临床参数、血型和疫苗接种状态在不同年龄组中的作用
Laila A Damiati,Mohammed A Baghdadi,Safa A Damiati et al.
Laila A Damiati et al.
Objectives: COVID-19 has had strong impacts on both global health systems and economies. Therefore, understanding disease severity and progression is crucial. This cross-sectional study aims to investigate possible link b...
Ferulic acid and not ascorbic acid reversed cardiac energy metabolism disruption in acute aluminum chloride exposed mice via PPARα/AMPK pathway [0.03%]
白杨素而非抗坏血酸通过PPARα/AMPK信号通路逆转急性铝暴露小鼠心脏能量代谢紊乱
Olufemi I Oluranti,Lawrence D Adedayo,Esther O Ojo-Ayangoke et al.
Olufemi I Oluranti et al.
Objectives: Proper cardiac function depends on adequate supply and metabolism of energy substrates. Aluminum chloride exposure has been linked to adverse cardiac events. This study investigated the ameliorative effect of ...
Gestational diabetes mellitus and long-term cancer risk: a narrative review of epidemiological and mechanistic evidence [0.03%]
妊娠期糖尿病与长期癌症风险：流行病学和机制证据的综述式回顾
Ana Lúcia Abdo Ladeira
Ana Lúcia Abdo Ladeira
Gestational diabetes mellitus (GDM) is a common metabolic complication of pregnancy and is increasingly recognized as a marker of long-term metabolic vulnerability. Beyond its established association with cardiometabolic diseases, emerging ...
GDF-11 triggers cold-induced browning and metabolic activation of adipose tissue [0.03%]
GDF-11触发冷诱导的脂肪组织褐变和代谢活化
Serena Sagliocchi,Lucia Acampora,Caterina Miro et al.
Serena Sagliocchi et al.
Objectives: White adipose tissue (WAT) browning enhances energy expenditure and represents a promising target for metabolic disease. Growth differentiation factor 11 (GDF-11), a circulating member of the TGF-β superfamil...
Environmental diabetogens: biochemical links between microplastic exposure, endocrine disruption, and glucose metabolic dysfunction [0.03%]
环境糖尿病发病因素：微塑料暴露、内分泌干扰和葡萄糖代谢紊乱之间的生化联系
Robin Singh,Jaspreet Kaur,Bhumika Upadhyay
Robin Singh
The increase in the incidence of type 2 diabetes mellitus (T2DM) worldwide cannot be attributed solely to genetic and lifestyle factors, underscoring the growing role of environmental metabolic disruptors. Microplastics are increasingly bei...
Serum bilirubin as a predictor of complicated appendicitis: a diagnostic accuracy study [0.03%]
血清胆红素作为复杂性阑尾炎预测因素的诊断准确性研究
Edwin Joy,Thesneem Changanath Kader
Edwin Joy
Objectives: Early identification of complicated acute appendicitis remains a clinical challenge. Serum bilirubin has been proposed as a potential biomarker reflecting disease severity rather than primary diagnosis. To eva...
Neurophysiology of abdominal pain: a review of peripheral, spinal, central mechanisms and emerging research trends [0.03%]
腹部疼痛的神经生理学：外周、脊髓和中枢机制及新兴研究趋势综述
Ravindran Revand,Rani Kumari
Ravindran Revand
Experience of visceral pain occurs when there is discomfort originating from internal organs of the body, often resulting from injury, infection, inflammation, ischemia, tumors, or neuropathy. In clinical practice, visceral pain is recogniz...
Ahmed A Sedik,Renad Alrefaei
Ahmed A Sedik
Hepatic encephalopathy (HE) encompasses a wide spectrum of neuropsychiatric disturbances that arise as a consequence of acute or chronic liver dysfunction. It represents a critical event in the natural history of cirrhosis and serves as an ...
Ginsenoside Rg1 attenuates right ventricular remodeling in hypoxic pulmonary hypertension and is associated with suppression of HIF-1α-related glycolytic signaling [0.03%]
人参皂苷Rg1通过抑制HIF-1α相关的糖酵解信号通路缓解缺氧性肺动脉高压右心室重塑作用
Peng He,Wei Tan,Yanjie Zhu et al.
Peng He et al.
Objectives: To determine whether ginsenoside Rg1 attenuates right ventricular remodeling in hypoxic pulmonary hypertension and whether this effect is associated with suppression of HIF-1α-related glycolytic signaling. ...