Enhanced citric acid production via aconitase co-inhibition strategy using L-cysteine HCl-resistant Aspergillus niger NA-CYS3 [0.03%]
L-半胱氨酸盐酸盐抗性菌株Aspergillus niger NA-CYS3介导的酶法协同抑制提高柠檬酸发酵滴度
Nudrat Jabeen,Mahmood Ul Hassan,Sikander Ali et al.
Nudrat Jabeen et al.
The present study presents a new approach to boost citric acid production by combining genetic improvement and enzyme inhibition in the fungus Aspergillus niger. A mutant strain, named NA-CYS3, was developed by chemically treating the wild-...
Intergenic trans-splicing-driven formation of a chimeric FAM168B::ANKRD42 transcript in prostate cancer [0.03%]
前列腺癌中由反式剪接形成的FAM168B::ANKRD42嵌合转录本的形成
Sidharth Dash Sharma,Sreemoyee Sensharma,Arne Kutzner et al.
Sidharth Dash Sharma et al.
The present study identifies a novel intergenic mRNA trans-splicing event that generates a previously uncharacterized chimeric transcript comprising family with sequence similarity 168 member B (FAM168B), and ankyrin repeat domain 42 (ANKRD...
Endophytic microorganisms as sustainable sources of antidiabetic metabolites: biochemical mechanisms, bioprospecting strategies, and translational challenges [0.03%]
内生微生物作为抗糖尿病代谢物的可持续来源：生化机制、生物勘探策略和转化挑战
Sherif B Adeyemi,Mercy A Alabi,Hafizah Y Chenia et al.
Sherif B Adeyemi et al.
Diabetes mellitus affects over 589 million adults globally, with projections exceeding 900 million by 2050. Conventional antidiabetic therapies are limited by adverse effects, high cost, and single-target pharmacology. Endophytic microorgan...
Study on the role and clinical relevance of gut microbiota in diabetic foot ulcers [0.03%]
糖尿病足溃疡发病机制中的肠道菌群作用及临床意义研究分析
Huayan Zheng,Jing Zhuang,Qinghua Lin et al.
Huayan Zheng et al.
Diabetic foot ulcers (DFU) are severe and costly complications of diabetes, predisposing to infection, amputation, and mortality, highlighting the urgent need to clarify their mechanisms for optimized clinical management. This study integra...
Tongfu Pingchuan decoction enhances Chrm4 expression in intestinal macrophages to alleviate sepsis in rats [0.03%]
通腑平喘汤通过上调肠系膜巨噬细胞中乙酰胆碱受体表达缓解脓毒症大鼠内脏功能障碍的作用研究
Limeng Yang,Jialong Qi,Jun Wang et al.
Limeng Yang et al.
This study aims to explore the protective role of Tongfu Pingchuan decoction (TFP) on sepsis. Thirty rats were randomly assigned to Sham, sepsis (cecal ligation and puncture, CLP), and CLP + Tongfu Pingchuan decoction (TFP) groups (n = 10 p...
Transparent keratin nanocomposite films incorporating silver nanoparticles and aloe vera for wound management [0.03%]
一种用于伤口管理的掺入银纳米颗粒和芦荟凝胶的角蛋白纳米复合素薄膜
S Anitha,Srividya Shivakumar
S Anitha
Keratin was extracted from human hair waste and incorporated with neem-mediated silver nanoparticles (AgNPs), carboxymethyl cellulose, and aloe vera to fabricate a transparent nanocomposite film. The extracted keratin exhibited a characteri...
Cyanobacteria as biochemical treasure troves: unveiling bioactive metabolites for pharmaceutical and global sustainability [0.03%]
蓝藻作为生化宝库：揭示具有药用和全球可持续发展价值的生物活性代谢产物
Surbhi Kharwar,Zeba Parveen,Rahul Prasad Singh et al.
Surbhi Kharwar et al.
Cyanobacteria, among the most ancient and versatile microorganisms on Earth, thrive across different aquatic ecosystems, ranging from freshwater to marine environments. In addition to being important producers of structurally diverse second...
Engineering the flexibility of the β-sheet containing Y58 in L-aspartate-α-decarboxylase to relieve mechanism-based inactivation [0.03%]
通过在L-天冬氨酸-α-脱羧酶中的β-折叠体含Y58以缓解基于机制的失活工程改造Y58的灵活性
Junping Zhou,Feng Wang,Yingli Zhao et al.
Junping Zhou et al.
Aspartate-α-decarboxylase (ADC) catalyzes the decarboxylation of L-aspartate to produce β-alanine, while was restricted for applications by its mechanism-based inactivation. Here the flexibility of the β-sheet containing Y58, a critical ...
XBP1 gene silencing augments quercetin-induced apoptosis and anti-metastatic activity in breast cancer cell lines [0.03%]
XBP1基因沉默增强芸香素诱导的乳腺癌细胞系凋亡及抑制转移作用
Sedef Akçaalan,Canan Eroğlu Güneş,Ercan Kurar
Sedef Akçaalan
This study investigated the combined effects of quercetin (Que) and shRNA-mediated XBP1 silencing on the MCF7 and MDA-MB-231 breast cancer cell lines. Que was selected because of its well-known anticancer effects. XBP1, on the other hand, w...
Discovery of lactic acid bacteria metabolites as quorum sensing inhibitors suppressing Aeromonas hydrophila virulence [0.03%]
类乳酸菌的代谢产物作为群体感应抑制剂以抑制气单胞菌致病性研究发现
M Fiqriansyah Wahab,Nisa Rachmania Mubarik,Baso Manguntungi et al.
M Fiqriansyah Wahab et al.
Metabolites derived from 33 lactic acid bacteria (LAB) isolates were screened for quorum sensing (QS) inhibitory activity against Aeromonas hydrophila using Chromobacterium violaceum as a biosensor. Three isolates (AZMS2, AZMFK2, and AZMDH7...