Correlation of autophagy and Alzheimer's disease with special emphasis on the role of phosphodiesterase-4 [0.03%]
自噬与阿尔茨海默病的相关性及其对磷酸二酯酶-4的作用研究
Aniruddha Banerjee,Dithu Thekkekkara,S N Manjula et al.
Aniruddha Banerjee et al.
Autophagy disruption is important in Alzheimer's disease (AD) as it prevents misfolded proteins from being removed, which leads to the accumulation of amyloid plaques and neurofibrillary tangles (NFTs). Restoring autophagy improves neuronal...
Marine polysaccharides from green seaweeds belonging to the class Ulvophyceae mitigate cyclophosphamide-induced immunosuppression: an in vivo study [0.03%]
绿藻类海洋多糖缓解环磷酰胺所致免疫抑制：体内实验研究
Shilpa Kamalakar Pai,Akkarapaka Neelima,Kajal Chakraborty et al.
Shilpa Kamalakar Pai et al.
Polysaccharides derived from seaweeds possess notable immunomodulatory and antioxidant properties. This study investigated the therapeutic potential of polysaccharides extracted from four green seaweed species-Ulva reticulata (URP), Ulva la...
Israt Jahan,Mohammad Harun-Ur-Rashid,Mohammed S Almuhayawi et al.
Israt Jahan et al.
This review highlights the transformative applications of ultrafast technologies in biotechnology, focusing on their ability to provide real-time visualization and precise manipulation of biomolecular processes. Femtosecond lasers have enha...
High resilience of human cerebellum in Alzheimer's disease: reciprocal coupling of cellular anabolic and catabolic fluxes enable intensive neuroprotection [0.03%]
人类小脑在阿尔茨海默病中的高恢复力：细胞合成和分解代谢的相互耦合实现高强度神经保护
Brijesh Baghel,Bindu Kumari,Anindita Bhattacharjee et al.
Brijesh Baghel et al.
We elucidate that the cerebellum displays striking resilience to neurodegenerative changes under aging or Alzheimer's disease (AD). We identify the neurobiological factors that underlie the natural neuroprotective characteristic of cerebell...
Purification and characterization of a bacteriocin produced by the probiotic Lactiplantibacillus plantarum subsp. argentoratensis s train I1B [0.03%]
由益生菌植物乳杆菌茵株I1B亚种阿根苏丹ensis产生的细菌素的纯化和表征
Jahnavi Kumari Singh,Palanisamy Bruntha Devi,Potunuru Uma Rani et al.
Jahnavi Kumari Singh et al.
This study is aimed to characterize a broad-spectrum bacteriocin produced by Lactiplantibacillus plantarum subsp. argentoratensis strain I1B of fermented food origin and also to evaluate the in vitro probiotic properties of this strain. Cel...
Transcriptomic signatures of prostate cancer progression: a comprehensive RNA-seq study [0.03%]
基于RNA测序的前列腺癌进展转录标志物研究
Shristi Modanwal,Viswajit Mulpuru,Ashutosh Mishra et al.
Shristi Modanwal et al.
Transcriptomics has been entirely transformed by RNA-sequencing (RNA-seq) due to its high sensitivity, accuracy, and precision. This study analyzed RNA-seq data to identify potential biomarkers for prostate cancer (PCa), a serious health is...
Investigating cigarette smoke-induced airway inflammation and sperm activity impairment in rats based on cilia-associated proteins [0.03%]
基于纤毛相关蛋白研究烟草烟雾致大鼠气道炎症及精子活动力损伤机制
Lei Wang,Min Pan,Jinhui Dong et al.
Lei Wang et al.
The aim of this study was to investigate the mechanism of smoking-induced chronic obstructive pulmonary disease (COPD) and its impact on reproductive function in male rats and its relationship with chronic lung inflammation. The study used ...
Design, synthesis, and pharmacological evaluation of heteroaryl thiol-linked kojic acid derivatives as a novel class of acetylcholinesterase inhibitors for Alzheimer's disease therapy [0.03%]
设计、合成及药理评价异芳香族硫醇连接的 koji 酸衍生物作为一类新型乙酰胆碱酯酶抑制剂用于阿尔茨海默病治疗
Madan Singh,Chandrabose Karthikeyan,Digambar Kumar Waiker et al.
Madan Singh et al.
Natural products have long served as versatile templates for discovering lead molecules against various targets of pharmacological interest. Kojic acid, a fungal metabolite epitomizes this versatility as it elicits broad-spectrum biological...
Genetically engineered silk fibroin with antibacterial and antioxidant properties [0.03%]
具有抗菌和抗氧化性能的转基因丝素蛋白
Chitra Manoharan,Dyna Susan Thomas,Rasalkar Sandhya Yashwant et al.
Chitra Manoharan et al.
Bombyx mori silk fibroin and the antimicrobial peptide cecropin B are promising biomolecules for biomedical applications due to their unique and complementary properties. In this study, we successfully expressed recombinant silk fibroin (R....
Synergistic activity of synbiotic blend between Lactococcus lactis KAFF 1-4 and fibersol-2 on gut microbiota modulation and anti-VRE properties [0.03%]
植物乳杆菌KAFF 1-4与Fibersol-2的合生元混合物对肠道菌群调控和抗VRE的作用研究
Witida Sathitkowitchai,Kevin Mok,Patkakorn Udomsri et al.
Witida Sathitkowitchai et al.
The study evaluated the effectiveness of a synbiotic blend containing Lactococcus lactis KA-FF 1-4 and Fibersol-2 in modulating gut microbiota and inhibiting vancomycin-resistant Enterococcus (VRE). Compared to probiotic or prebiotic treatm...