Insight into improved specificity and thermostability of Geobacillus zalihae T1 lipase by introducing novel molecular interactions via phenylalanin to cysteine substitution [0.03%]
通过苯丙氨酸到半胱氨酸的替代引入新型分子相互作用提高Geobacillus zalihae T1脂肪酶特异性和热稳定性的见解
Samah Hashim Albayati,Muna Hilal Shabeeb,Oluwasola Michael Akinola et al.
Samah Hashim Albayati et al.
Lipase specificity is a crucial requirement for industrial employment; however, tuning the lipase specificity in some cases can impair the structure and affect its stability. To enhance the T1 lipase specificity, we targeted the conserved b...
Exosome miR-152-3p derived from small intestinal epithelium modulates aging process in adipocytes [0.03%]
小肠上皮来源的外泌体miR-152-3p调控脂肪细胞衰老过程
Wenjuan Di,Cheng Xue,Yunyun Lin et al.
Wenjuan Di et al.
Exosomes play a crucial role in facilitating intracellular communication between cells and tissues. The small intestine epithelium secretes exosomes, which is involved in various physiologic and pathologic processes. In this study, we inves...
Unlocking the potential of Artemisia annua for artemisinin production: current insights and emerging strategies [0.03%]
解读 Artemisia annua 中青蒿素的潜力：当前见解与新兴策略
Divya Vashisth,Sudhanshu Mishra
Divya Vashisth
Malaria is a deadly disease, and the best effective treatments depend on artemisinin, a sesquiterpene lactone compound isolated from the plant Artemisia annua. However, artemisinin is produced in very small amount within the plant which is ...
QBD-based optimization of sequential extraction of anthocyanins from Krishna Tulsi (Ocimum tenuiflorum): investigation of its bioactivities for biomedical applications [0.03%]
基于QBD的Krishna Tulsi（Ocimum tenuiflorum）花色苷顺序提取优化：其生物活性的探究及其在生物医药领域的应用
Amrita Chatterjee,Rajdeep Saha,Ravi Adinarayan Somabattini et al.
Amrita Chatterjee et al.
Krishna Tulsi (Ocimum tenuiflorum L.), is known for its rich polyphenolic composition, including anthocyanins, which contribute to its bioactivity. Efficient extraction methods are critical to maximizing the yield of these bioactive compoun...
Ability to use ITS and rbcL sequencing for determination of the genetic diversity and relationships among olive (Olea europaea L.) genotypes [0.03%]
ITS和rbcL序列分析在橄榄（Olea europaea L.）种质遗传多样性和亲缘关系研究中的应用能力
Sobhan Firouzi,Mahmood Solouki,Bahman Fazeli-Nasab et al.
Sobhan Firouzi et al.
Olives are of considerable economic and commercial importance and are mostly used in both daily life and industries. The DNA barcode method has a lot of potential for reviving the science of arithmetics and traditional biodiversity studies,...
Green Synthesis of Cymodocea serrulata Zinc Oxide Nanoparticles for Sustainable Antibacterial, and Mosquito Control and their Toxicity to non-target Organisms [0.03%]
利用海洋植物绿合氯叶藻锌纳米颗粒的合成及其可持续抗菌、控蚊和对非靶生物毒性研究
Vadivel Amutha,Paramasivam Deepak,Chidambaram Tamilselvan et al.
Vadivel Amutha et al.
Mosquito-borne diseases such as dengue, malaria, and filariasis have become serious global health concerns due to their contagious nature and widespread prevalence. In this study, ZnO NPs biosynthesized using the seagrass extract of Cymodoc...
Elucidating the mechanisms of echinocandin B biosynthesis under fatty acid feeding in Aspergillus nidulans based on genome and transcriptome sequencing [0.03%]
基于基因组和转录组测序揭示脂肪酸诱导下粗糙脉抱菌棘白菌素B生物合成机制
Xiaozhang Yang,Lianggang Huang,Kai Wang et al.
Xiaozhang Yang et al.
Echinocandin B (ECB), a non-ribosomal lipopeptide synthesized by ascomycete fungi, serves as a first-line therapeutic agent for invasive fungal infections. While the biosynthetic gene clusters of ECB have been identified in several Aspergil...
Toxicity profiling and HR-LCMS analysis of Indigofera longiracemosa leaf methanolic extract exhibiting anti-inflammatory activity [0.03%]
展现抗炎活性的Indigofera longiracemosa叶甲醇提取物的毒性分析和HR-LCMS分析
Aswathy Chankaramkandath Vasu,Vignesh Attuvalappil Ravidas,Sheeja T Tharakan et al.
Aswathy Chankaramkandath Vasu et al.
Indigofera longiracemosa, a member of the Fabaceae family documented in traditional medicine for its therapeutic potential, holds promise as a viable natural indigo source. The dearth of reliable and coherent research on the safety and medi...
De novo assembly, gene annotation and marker development using illumina paired-end transcriptome sequences in nutmeg (Myristica fragrans Houtt .) [0.03%]
基于 Illumina 高通量测序的肉豆蔻转录组从头拼接组装、基因注释及分子标记开发
Otih Rostiana,Rubi Heryanto,Tias Arlianti et al.
Otih Rostiana et al.
Nutmeg (Myristica fragrans) is a high-value spice crop widely utilized in culinary, medicinal, and industrial sectors. Despite its economic and cultural significance, genetic research on nutmeg is severely limited, hindering efforts to impr...
Exploring the modern approaches to enhance fungal endophyte-derived bioactive secondary metabolites [0.03%]
探究增强真菌内生菌生物活性次级代谢物的现代方法
Palakjot Kour Sodhi,Tanveer Kour,Gursharan Kaur et al.
Palakjot Kour Sodhi et al.
Over the past few decades, microbial-derived bioactive compounds have been tested for antiviral, antimicrobial, and anticancer properties. In addition, fungal-derived bioactive secondary metabolites (SMs) are increasingly being suggested as...