Reversal of diabetes-associated cognitive impairment through modulation of BDNF, insulin, and NF-κB pathways by a marketed herbal formulation [0.03%]
黄连解毒汤通过调节BDNF、胰岛素和NF-κB信号途径逆转糖尿病相关认知障碍
Nabeel Kinattingal,Venugopal Bovilla,Seema Mehdi et al.
Nabeel Kinattingal et al.
Diabetes-associated cognitive impairment is a recognized complication of chronic hyperglycemia affecting learning and memory. We investigated whether Tamarindus indica seed extract (TSE) and Diabecon, a marketed herbal formulation (MHF), co...
Sustainable agriculture: benefits of slurry microbial fertilizer on corn yield and soil ecology [0.03%]
可持续农业：粪便微生物肥料对玉米产量和土壤生态的影响
Keran Li,Li He,Ning Wang et al.
Keran Li et al.
Abstract: The rapid development of circular agriculture has led to the secondary agricultural pollutants such as biogas slurry. Biogas slurry fermentation enriches beneficial microbial communities, enhances nutrient conte...
In-vivo evaluation of neuroprotective effect of methanolic extract of Turbinaria ornata combined with AKG against aluminium chloride-induced Alzheimer's in Wistar rats [0.03%]
甲基营养琼脂提取物联合AKG对抗Wistar大鼠铝氯化物诱导的阿尔茨海默病的神经保护作用的体内评价
Deepika Kale,Ishwarya Ramachandran,Sreeja Lakshmi et al.
Deepika Kale et al.
The progressive neurodegenerative disease known as Alzheimer's disease (AD) is typified by behavioral abnormalities and cognitive deterioration. In the current investigation, the preventive potential of a combination formulation of alkyl gl...
Nitro-substituted tert-butyl peresters induce apoptosis and exhibit multi-targeted anticancer activity in breast cancer cells [0.03%]
硝基取代的叔丁基过代酯诱导乳腺癌细胞凋亡及多靶点抗癌活性
Hedyeh Zafari,Raheleh Shakeri,Khadijeh Pouraghajan et al.
Hedyeh Zafari et al.
The anticancer effects of six tert-butyl peresters derivatives were investigated against MDA‑MB‑231 (triple‑negative) and MCF‑7 (hormone receptor‑positive) breast cancer cells. Specifically, only the nitro‑substituted derivatives, inc...
Alogliptin-metformin synergy ameliorates diabetes-associated bone loss via modulation of DPP-4 activity and OPG/RANKL signaling [0.03%]
DPP-4抑制剂阿格列汀与二甲双胍联合使用通过调节OPG/RANKL信号缓解糖尿病相关骨量减少的作用及机制研究
Tufail Ahmad,Syed Sufian Ahmad,Faraha Ahmed et al.
Tufail Ahmad et al.
Type 2 diabetes mellitus (T2DM) disrupts normal bone remodeling and increases fracture risk; however, most antidiabetic therapies offer limited skeletal protection. This study evaluated the metabolic and bone-protective effects of aloglipti...
NRF2 activation by myrcene restores redox balance and metabolic homeostasis in a mouse model of type 2 diabetes [0.03%]
β-石竹烯通过激活NRF2恢复2型糖尿病小鼠模型中的氧化还原平衡和代谢稳态
Ruchi Pandey,Adarsh Kumar Ray,Priya Bisht et al.
Ruchi Pandey et al.
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterised by impaired insulin signalling, chronic hyperglycaemia, and associated metabolic dysfunction. Plant-derived bioactive compounds are increasingly explored as potential the...
Awanish Kumar,Sanjukta Vidyant,Vikas Sharma et al.
Awanish Kumar et al.
Visceral Leishmaniasis (VL) encompasses a broad range of manifestations of protozoan parasite Leishmania in human. This infection remains asymptomatic/subclinical in many cases, or can follow an acute, subacute, or chronic course. It advers...
Laccase immobilization on a natural lignocellulosic biomass support: optimization, characterization, and bisphenol A degradation [0.03%]
固定在天然木质纤维素生物质载体上的漆酶的固定化：优化、表征及双酚A降解
Metin Utku Koç,Ceyhun Işık
Metin Utku Koç
Laccase (LAC) was immobilized onto sponge gourd (Luffa cylindrica) through a two step method involving physical adsorption followed by glutaraldehyde-mediated crosslinking. The immobilization parameters were systematically optimized, result...
Drought-induced shifts in soil microbial communities and carbon dynamics in agricultural and forest soils of Bangladesh [0.03%]
干旱引起的孟加拉国农业和森林土壤微生物群落及碳动态变化
Abdullah Al Mamun
Abdullah Al Mamun
Drought significantly alters soil microbial activity and carbon cycling, yet its effects across contrasting land-use systems remain insufficiently understood. This study investigated drought-induced changes in microbial communities and carb...
USP39 reduces BRCA1 methylation to promote mitochondrial biogenesis and lower drug sensitivity in ovarian cancer through deubiquitinating ZC3H18 [0.03%]
USP39通过去泛素化ZC3H18降低卵巢癌中BRCA1甲基化以促进线粒体生物发生和降低药物敏感性
Jing Wang,Xinyu Li,Jianmiao Chang et al.
Jing Wang et al.
Ovarian cancer (OV) is a leading cause of mortality related to gynecological malignancies. Chemoresistance represents a major clinical obstacle. Carboplatin (CBP) is a first-line chemotherapeutic agent widely used for ovarian cancer treatme...