Exploring the neuroprotective role of Asparagus racemosus (Shatavari) in Alzheimer's disease: mechanisms, evidence, and future directions [0.03%]
探讨Asparagus racemosus（沙瓦里）在阿尔茨海默病中的神经保护作用：机制、证据和未来方向
Mohd Nadeem,Mohd Ashif Khan,Farhan Jalees Ahmad et al.
Mohd Nadeem et al.
Alzheimer's disease (AD), a progressive neurodegenerative disease, is characterized by cognitive decline, memory loss, and pathological features such as amyloid-beta plaques, tau hyperphosphorylation, oxidative stress, and neuroinflammation...
Fabrication of Achyranthes aspera extract loaded ZIF-8 nanocomposite for lung cancer treatment, an in vitro assessment [0.03%]
基于ZIF-8纳米复合材料的苍耳子提取物负载微球体对肺癌治疗的体外评估研究
Lakshmanan Govindan,Prabhu Raju,Surendirakumar Kannaiah et al.
Lakshmanan Govindan et al.
Medicinal plant-based biocompatible nanomaterials have become increasingly important in the healthcare field. Zeolitic imidazole (ZIF-8) frameworks are fascinating porous crystalline materials that have great attention in the field of drug ...
Biogenic synthesis and characterization of copper nanoparticles using Crossandra infundibuliformis leaves and evaluation of antimicrobial, antioxidant, cytotoxic analysis and wound healing activity on HaCaT cells [0.03%]
利用Crossandra infundibuliformis叶子进行生物合成和表征铜纳米颗粒及其抗菌，抗氧化，细胞毒性分析及对HaCaT细胞伤口愈合活性的研究
Reya Rene Philip,Jayashri Seetharaman,R Akshaya Priya et al.
Reya Rene Philip et al.
The objective of this study is to assess functional groups and phytochemical components of Crossandra infundibuliformis leaf extract, characterisation of green synthesised copper nanoparticles and evaluation of their Antimicrobial, Antioxid...
Exploring anticancer activity of baicalin, naringenin, and noscapine via binding and inhibition of sphingosine kinase 1 [0.03%]
黄芩素、芸苔素和可待因通过结合和抑制鞘氨醇-1-磷酸合成酶1抗肿瘤作用的研究
Ilma Shakeel,Taj Mohammad,Shaista Haider et al.
Ilma Shakeel et al.
Sphingosine kinase 1 (SphK1) is an essential enzyme in sphingolipid metabolism, catalyzing the phosphorylation of sphingosine to produce sphingosine-1-phosphate (S1P), a bioactive lipid with diverse roles in cell proliferation, survival, an...
Design and evaluation of carnosic acid-loaded thermosensitive lipidic nanogels for nasal delivery: ex vivo permeation, nasal ciliotoxicity, and antioxidant assessment [0.03%]
一种用于鼻给药的含右旋糖苷酸的热敏脂质纳米凝胶的设计与评价：体外渗透、鼻纤毛毒理和抗氧化评估
Musarrat Husain Warsi,Abuzer Ali,Mohd Aamir Mirza et al.
Musarrat Husain Warsi et al.
Carnosic acid (CA) is a diterpene phenolic compound derived from the leaves of Rosmarinus officinalis, known for its neuroprotective, anti-inflammatory, and antioxidant properties. However, its effectiveness is limited due to poor solubilit...
Adjunctive use of Streptococcus salivarius M18 probiotic in the treatment of periodontitis: a randomized controlled trial [0.03%]
乳球菌M18益生菌辅助治疗牙周炎的疗效研究：一项随机对照试验
Wei-Ju Chen,Lavanya Ajay Sharma,Peng Shao et al.
Wei-Ju Chen et al.
This randomized double-blind placebo-controlled clinical trial aimed to evaluate the adjunctive use of Streptococcus salivarius M18 probiotic lozenges in the treatment of periodontitis. Following non-surgical periodontal therapy (NSPT), 55 ...
pH-responsive silica nanocarriers of olaparib for augmenting anticancer activity: development, characterization, and in vitro cytotoxicity study against MCF-7 breast cancer cells [0.03%]
一种用于增强抗癌活性的PARP抑制剂奥拉帕尼的pH响应型介孔硅纳米载体：设计、表征及体外细胞毒性研究
Ankita Gupta,Swatantra K S Kushwaha,Amit Mishra
Ankita Gupta
This study focuses on the development and assessment of innovative chitosan-grafted silica nanocarriers encapsulating the PARP inhibitor, olaparib, designed for targeted delivery in breast cancer cells. The formulation aims to enhance thera...
Haplotype characterization of phosphorus homeostasis gene, SPX-MFS3 under combination of low nitrogen and phosphorus conditions in indica rice at seedling stage [0.03%]
低氮磷互作条件下水稻幼苗期磷稳态基因SPX-MFS3位点的单倍型分析（籼稻）
Baishnab Charan Muduli,Sabarinathan Selvaraj,Shivraj Sahu et al.
Baishnab Charan Muduli et al.
Plants establish a complex signalling network to acquire nitrogen (NO2⁻/NH4⁺) and phosphate (Pi) from the soil. In rice, OsSPX-MFS3 (LOC_Os06g0129400) has been characterized as a vacuolar low-affinity Pi transporter gene, which plays a cr...
Cleavage efficiency of CRISPR/Cas9 system with G-quadruplex-capped single-guide RNA motifs in RNase II and RNase R [0.03%]
RNase II和RNase R介导的具有G-四链体帽sgRNA骨架的CRISPR / Cas系统切割效率研究
Dung Thanh Dang
Dung Thanh Dang
Modification of sgRNA has been considered as a necessary approach to enhance the stability and cleavage efficiency of the CRISPR/Cas9 system. In this study, a rigid G-quadruplex structure was genetically applied to the 3' end of typical sgR...
Sustainable vinblastine production by Alternaria alternata, an endophytic fungus isolated from Catharanthus roseus in the Northern Himalayan Region [0.03%]
采自北喜马拉雅地区长春花的内生真菌Alternaria alternata的 Vinblastine 生物合成研究
Aditya Banyal,Rahul Thakur,Pryanka Thakur et al.
Aditya Banyal et al.
Vinblastine, a potent anticancer drug, is traditionally extracted from Catharanthus roseus, but its low yield and high production costs necessitate alternative sources. In this study, twelve endophytic fungi were isolated from Catharanthus ...