Process optimization for regulating ethyl acetate synthesis via co-fermentation of Wickerhamomyces anomalus and Saccharomyces cerevisiae [0.03%]
利用Wickerhamomyces anomalus和Saccharomyces cerevisiae共发酵优化乙酸乙酯合成路径
Zhilei Fu,Xiaoguang Liu,Yunzhong Wang et al.
Zhilei Fu et al.
To enhance the synthesis efficiency of ethyl acetate, a key flavor compound in Baijiu (Chinese liquor), a co-fermentation system was developed by integrating the high ethyl acetate-producing yeast Wickerhamomyces anomalus YF1503 with the hi...
Structural bioinformatics-based targeting of Epstein-Barr virus BPLF1 deubiquitinase activity against EBV infection and in-vitro validation [0.03%]
基于结构生物信息学的靶向Epstein-Barr病毒BPLF1去泛素酶活性以对抗EB病毒感染及体外验证
Atta Ullah,Saeed Ullah,Najeeb Ur Rehman et al.
Atta Ullah et al.
We screened an in-house library of ~ 900 natural and naturally derived compounds to identify potential inhibitors targeting the BPLF1 deubiquitinase of Epstein-Barr virus, a significant regulator of the NF-κB signaling pathway and viral DN...
Insights into gut microbiota-mediated inhibition of intervertebral disc degeneration by Bushen Huoxue prescription [0.03%]
补肾活血方通过调控肠道微生物介导椎间盘退变的作用及机制研究
Huiyi Peng,Honghui Li,Heng Lei et al.
Huiyi Peng et al.
Intervertebral disc degeneration (IDD) is the main factor of low back pain (LBP), and Bushen Huoxue prescription (BSHX) can treat the pain caused by IDD. We discussed the potential mechanism of BSHX in improving chronic inflammation caused ...
Causal effect of gut Streptococcus abundance on maternal genitourinary infection during pregnancy: a two-sample Mendelian randomization study [0.03%]
母体肠道链球菌丰度对孕期泌尿生殖系统感染影响的因果效应：两样本孟德尔随机化研究
Rihan Wu,Baoyin Batu,Jargalsaikhan Badarch et al.
Rihan Wu et al.
Genitourinary infections (GUIs) during pregnancy are a significant clinical concern linked to maternal morbidity. To investigate the potential causal effect of gut Streptococcus abundance on the risk of maternal genitourinary infection duri...
Statistical optimization of acid phosphatase production by Trichoderma spp. in submerged fermentation [0.03%]
稻绿革菌酸性磷酸酶液体发酵的统计学优化研究
Frederico Alves Lima,Jussara Maria Martins de Almeida Afonso,Amanda Rocha Carmelo et al.
Frederico Alves Lima et al.
The production of acid phosphatase (ACPase) by Trichoderma spp. was evaluated and optimized under submerged fermentation using low-cost culture media. Among the strains tested, T. reesei showed the highest enzymatic potential. A Central Com...
Harnessing genipin as a biocompatible crosslinker in nanomedicine for oncology applications [0.03%]
利用生物相容性交联剂genipin进行纳米医学抗肿瘤研究
Tanuj Sharma,Simranjit Kaur,Jai Bharti Sharma et al.
Tanuj Sharma et al.
Genipin-crosslinked nanocarrier systems demonstrate enhanced physicochemical and therapeutic performance across multiple platforms, including nanoparticles, liposomes, hydrogels, nanogels, and lipid-based systems. These systems consistently...
Chitosan loaded copper and selenium nanoparticles synergistically inhibit HepG2-hepatic cancer cells viability and angiogenesis [0.03%]
壳聚糖负载的铜和硒纳米颗粒协同抑制HepG2肝癌细胞活力和血管生成
Danar Shahbur,Maryam Ghobeh,Ali Es-Haghi et al.
Danar Shahbur et al.
Chitosan-stabilized copper-selenium nanoparticles (CS-Se-Cu NPs) were synthesized via a facile green reduction method using ascorbic acid as the reducing agent. The nanoparticles were comprehensively characterized by powder X-ray diffractio...
Comparative biochemical characterization and industrial potential of alkaline proteases from wild-type Bacillus subtilis PTK56 and its EMS-induced mutant [0.03%]
野生型芽孢杆菌PTK56和其乙基甲磺酸突变体中碱性蛋白酶的生化特性及工业潜力的比较研究
Tuna Karaytuğ,Burhan Arıkan
Tuna Karaytuğ
In this study, a wild-type alkaline protease-producing Bacillus strain isolated from soil was biochemically and molecularly characterized. The strain was identified as Bacillus subtilis PTK56 based on 16 S rRNA analysis. Random mutagenesis ...
Touxie Quyin Compound regulates histone lactylation-mediated Fabp4/5 and tissue-resident memory T cells to improve psoriasis recurrence in mice [0.03%]
透析祛银复方通过调控组蛋白乳酰化介导的脂肪酸结合蛋白及组织 resident memory T 细胞改善小鼠银屑病复发
Jiaqin Deng,Qiuping Liu,Wei Liu et al.
Jiaqin Deng et al.
Formula PSORI-CM01 has been used to alleviate psoriasis symptoms. Here, we developed a novel formula, Touxie Quyin Compound (TQC), which is composed of PSORI-CM01 and Artemisia annua. This study evaluated its therapeutic effects and the und...
From predicted interfaces to measured affinity: mapping a growth-factor receptor binding mechanism relevant to meniscus regeneration [0.03%]
从预测的界面到测量的亲和力：映射与半月板再生相关的生长因子受体结合机制
Longfei Zhao,Shiliang Hu,Zhihao Li et al.
Longfei Zhao et al.
To delineate the molecular recognition features of the FGF7-FGFR2b signaling axis relevant to meniscus regeneration, we integrated AI-based structural modeling (AlphaFold3), mutational energetics, molecular dynamics (MD) simulations, and is...