Delineating a Pathway for the Discovery of Functional Connectome Biomarkers of Autism [0.03%]
自闭症功能连接组生物标志物的发现途径研究
Shinwon Park,Phoebe Thomson,Gregory Kiar et al.
Shinwon Park et al.
The promise of individually tailored care for autism has driven efforts to establish biomarkers. This chapter appraises the state of precision-medicine research focused on biomarkers based on the functional brain connectome. This work is gr...
David G Amaral,Derek Sayre Andrews,Christine Wu Nordahl
David G Amaral
Since the early 1990s, there have literally been thousands of reports related to magnetic resonance imaging of the autistic brain. The goals of these studies have ranged from identifying the earliest biological predictors of an autistic dia...
Towards Biomarkers for Autism Spectrum Disorder: Contributions of Magnetoencephalography (MEG) [0.03%]
向自闭症谱系障碍的生物标志物迈进：脑磁图(MEG)的贡献
Timothy P L Roberts,William C Gaetz,Charlotte Birnbaum et al.
Timothy P L Roberts et al.
There is no simple blood test for autism. Consequently, much attention has been paid to identifying noninvasive biomarkers using imaging (e.g., Magnetic resonance imaging, MRI) and electrophysiological (e.g., electroencephalography, EEG and...
Mismatch Negativity (MMN) as a Pharmacodynamic/Response Biomarker for NMDA Receptor and Excitatory/Inhibitory Imbalance-Targeted Treatments in Schizophrenia [0.03%]
用于精神分裂症N-甲基-D天冬氨酸受体和兴奋性/抑制性不平衡靶向治疗的药物动力学/反应生物标志物失匹配负波（MMN）
Daniel C Javitt
Daniel C Javitt
Schizophrenia is a major mental disorder that affects approximately 0.5% of the population worldwide. Persistent negative symptoms and cognitive impairments associated with schizophrenia (CIAS) are key features of the disorder and primary p...
Neurophysiological Models in Individuals at Clinical High Risk for Psychosis: Using Translational EEG Paradigms to Forecast Psychosis Risk and Resilience [0.03%]
临床高风险个体的精神病生理学模型：使用转化EEG范式预测精神病的危险性和韧性
Holly K Hamilton,Daniel H Mathalon
Holly K Hamilton
Over the last several decades, there have been major research efforts to improve the identification of youth and young adults at clinical high-risk for psychosis (CHR-P). Among individuals identified as CHR-P based on clinical criteria, app...
Altered Sleep Oscillations as Neurophysiological Biomarkers of Schizophrenia [0.03%]
睡眠振荡异常作为精神分裂症的神经生理生物标志物
Ahmad Mayeli,Francesco L Donati,Fabio Ferrarelli
Ahmad Mayeli
Sleep spindles and slow waves are the two main oscillatory activities occurring during nonrapid eye movement (NREM) sleep. Here, we will first describe the electrophysiological characteristics of these sleep oscillations along with the neur...
Gamma Oscillations as a Biomarker of Neural Circuit Function in Psychosis: Where Are We, and Where Do We Go from Here? [0.03%]
幻觉障碍神经环路功能的生物标志物——γ振荡：我们处于什么位置，将来向何处去？
Kevin M Spencer
Kevin M Spencer
This chapter is a selective and critical review of the literature on gamma oscillations in schizophrenia and related studies in other relevant fields that pertain to the hypothesis that abnormal gamma oscillations underlie symptoms of psych...
The Use of Event-Related Potentials in the Study of Schizophrenia: An Overview [0.03%]
事件相关电位在精神分裂症研究中的应用概述
Lindsey M Crown,Robert E Featherstone,Janet L Sobell et al.
Lindsey M Crown et al.
Event-related potentials (ERPs) are small voltage changes in the brain that reliably occur in response to auditory or visual stimuli. ERPs have been extensively studied in both humans and animals to identify biomarkers, test pharmacological...
Amber M Howell,Alan Anticevic
Amber M Howell
Schizophrenia is a debilitating neuropsychiatric disorder that affects approximately 1% of the population and poses a major public health problem. Despite over 100 years of study, the treatment for schizophrenia remains limited, partially d...
Monica N O&#x;Connell,Annamaria Barczak
Monica N O&#x;Connell
Animal models of neuropsychiatric disorders with appropriate biomarkers can greatly inform the neurobiological basis of disorder-related deficits of cognitive and/or sensory processes. Given the genetic, physiologic, and behavioral similari...