Emergence of the Hippocampus as a Vector for Goal-Directed Spatial Navigation [0.03%]
海马体在目标导向空间导航中的作用机制及其演化发育规律的研究进展
Susumu Takahashi,Fumiya Sawatani,Kaoru Ide
Susumu Takahashi
The hippocampus, which is deeply involved in episodic memory, plays a pivotal role in spatial navigation, an essential animal behavior. Spatial navigation requires the calculation of the distance and direction from a current to the final po...
Determination of Neuronal Activity and Its Meaning for the Processes of Learning and Memory [0.03%]
神经元活动的确定及其对学习和记忆过程的意义
Yuri I Alexandrov,A A Sozinov,O E Svarnik et al.
Yuri I Alexandrov et al.
Despite the years of studies in the field of systems neuroscience, the functions of neural circuits and behavior-related systems are still not entirely understood. The systems description of brain activity has recently been associated with ...
The Less Things Change, the More They Remain the Same: Impaired Neural Plasticity as a Critical Target for Drug Development in Neuropsychiatry [0.03%]
变化的是相同的：神经可塑性受损是 neuropsychiatry 药物开发的关键目标
Joshua T Kantrowitz,Daniel C Javitt
Joshua T Kantrowitz
Neuropsychiatric disability is related to reduced ability to change in response to clinical interventions, e.g., plasticity. Study of biomarkers and interventional strategies for plasticity, however, are sparse. In this chapter, we focus on...
Visual Neurophysiological Biomarkers for Patient Stratification and Treatment Development Across Neuropsychiatric Disorders [0.03%]
神经精神疾病患者的视觉神经生理生物标志物的分类和治疗方法的发展
Antígona Martínez,Steven A Hillyard,Daniel C Javitt
Antígona Martínez
The human visual system begins in the retina and projects to cortex through both the thalamocortical and retinotectal visual pathways. The thalamocortical system is divided into separate magnocellular and parvocellular divisions, which enga...
Biomarkers for Cognitive Control, Response Inhibition, Aggressivity, Impulsivity, and Violence [0.03%]
认知控制、反应抑制、攻击性、冲动性和暴力行为的生物标志物
Matthew J Hoptman,Ragy R Girgis,Daniel C Javitt
Matthew J Hoptman
Deficits in cognitive control contribute to behavioral impairments across neuropsychiatric disorders. Cognitive control is captured as a construct in the Research Domain Construct (RDoC) matrix and incorporate subdomains of goal selection, ...
Categorical and Dimensional Approaches for Psychiatric Classification and Treatment Targeting: Considerations from Psychosis Biotypes [0.03%]
精神病分类和治疗靶点的类别与维度方法：来自精神病生物亚型的考量
Brett A Clementz,Michal Assaf,John A Sweeney et al.
Brett A Clementz et al.
Categorical diagnosis, a pillar of the medical model, has not worked well in psychiatry where most diagnoses are still exclusively symptom based. Uncertainty continues about whether categories or dimensions work better for the assessment an...
Victoria L Fisher,Gabriel X Hosein,Boris Epié et al.
Victoria L Fisher et al.
Auditory-verbal hallucinations (AVH) are debilitating symptoms experienced by those diagnosed with psychosis as well as many other neurological and psychiatric disorders. Critical to supporting individuals with AVH is identifying biomarkers...
Sophie Holmes,Sule Tinaz
Sophie Holmes
Idiopathic Parkinson's disease (PD) is a neurodegenerative disorder that affects multiple systems in the body and is characterized by a variety of motor and non-motor (e.g., psychiatric, autonomic) symptoms. As the fastest growing neurologi...
Translating Decades of Neuroscience Research into Diagnostic and Treatment Biomarkers for ADHD [0.03%]
几十年来将神经科学研究转化为注意力缺陷多动障碍的诊断和治疗生物标志物
Sandra K Loo,Agatha Lenartowicz,Luke J Norman et al.
Sandra K Loo et al.
In this chapter, we review scientific findings that form the basis for neuroimaging and neurophysiological biomarkers for ADHD diagnosis and treatment. We then highlight the different challenges in translating mechanistic findings into biom...
EEG Biomarkers for Autism: Rational, Support, and the Qualification Process [0.03%]
自闭症 EEG 生物标志物：逻辑、支持及认定流程
Caitlin M Hudac,Sara Jane Webb
Caitlin M Hudac
In this chapter, we highlight the advantages, progress, and pending challenges of developing electroencephalography (EEG) and event-related potential (ERP) biomarkers for use in autism spectrum disorder (ASD). We describe reasons why global...