Alexei Verkhratsky,Chenju Yi,Jianqin Niu et al.
Alexei Verkhratsky et al.
The evolution of the nervous system emerged in primaeval animals to coordinate their behaviour then advanced by the division of function between neurones and neuroglia; neurones became dedicated to information processing and neuroglia speci...
Jianqin Niu,Alexei Verkhratsky,Arthur Butt et al.
Jianqin Niu et al.
Oligodendroglia are the only cell lineage of the central nervous system (CNS) responsible for producing myelin. They originate from precursor cells known as oligodendrocyte precursor cells (OPCs), which are born around the ventricular zones...
Russell W Chan,Bradley Jay Edelman,Shui Ying Tsang et al.
Russell W Chan et al.
Systems neuroscience explores the intricate organization and dynamic function of neural circuits and networks within the brain. By elucidating how these complex networks integrate to execute mental operations, this field aims to deepen our ...
Multilayer Analysis of RNA Sequencing Data in Alzheimer's Disease to Unravel Molecular Mysteries [0.03%]
多层分析阿尔茨海默病的RNA测序数据以解开分子之谜
Dilara Uzuner,Atılay İlgün,Elif Düz et al.
Dilara Uzuner et al.
Alzheimer's disease (AD) is a complex disease, and numerous cellular events may be involved in etiology. RNAseq-based transcriptome data hold multilayer information content, which could be crucial in unraveling molecular mysteries of AD. It...
Minshu Li,Qiang Liu
Minshu Li
Over the past decades, a large number of immunomodulatory or immunosuppressive treatments have been approved to treat central nervous system (CNS) demyelinating disorders such as multiple sclerosis (MS). Owing to the heterogeneity of patien...
Xiaoyan Sun,Weiqi Zhang
Xiaoyan Sun
As our population continues to age, the search for effective therapeutic strategies to combat neurodegenerative diseases, particularly Alzheimer's disease (AD), has become more pressing than ever. For over a decade, researchers have focused...
Pengfei Guo,Yanxiang Deng
Pengfei Guo
The human brain's complexity is underpinned by billions of neurons and trillions of synapses, necessitating coordinated activities across diverse cell types. Conventional techniques like in situ hybridization and immunohistochemistry, while...
Fuqiang Xu,Qing Liu
Fuqiang Xu
Neural circuits provide an anatomical basis for functional networks. Therefore, dissecting the structure of neural circuits is an indispensable prerequisite to understanding how the brain functions. Knowing how the neural circuits organize ...
Adeno-associated Virus-Mediated Gene Delivery Across the Blood-Brain Barrier [0.03%]
血液脑屏障转染的腺相关病毒载体基因递送技术
Yizheng Yao,Fengfeng Bei
Yizheng Yao
Recombinant adeno-associated viruses (AAVs) have emerged as a popular tool for gene therapy in the central nervous system (CNS). Given the dense vasculature in the CNS, systemic administration is an appealing approach for achieving a broad ...
Modelling and Controlling System Dynamics of the Brain: An Intersection of Machine Learning and Control Theory [0.03%]
脑的系统动力学建模与控制：机器学习与控制理论的交叉点
Quanying Liu,Chen Wei,Youzhi Qu et al.
Quanying Liu et al.
The human brain, as a complex system, has long captivated multidisciplinary researchers aiming to decode its intricate structure and function. This intricate network has driven scientific pursuits to advance our understanding of cognition, ...