Eneritz López-Muguruza,Carla Peiró-Moreno,Asier Ruiz et al.
Eneritz López-Muguruza et al.
Multiple sclerosis (MS) is a chronic autoimmune and progressive neurodegenerative disease of the central nervous system (CNS) that has a highly variable clinical manifestation and course. MS targets primarily myelin and oligodendroglia; how...
Katarzyna Pieczonka,Oliver Zhang,Sogolie Kouhzaei et al.
Katarzyna Pieczonka et al.
This chapter provides a comprehensive review of white matter injuries, with a particular focus on oligodendrocyte lineage cell-mediated mechanisms and strategies. Traumatic mechanical insults, vascular conditions, perinatal injuries, and de...
Alexei Verkhratsky,Jianqin Niu,Chenju Yi et al.
Alexei Verkhratsky et al.
Leukodystrophies are a diverse group of inherited diseases characterised by white matter degenerative pathology. Leukodystrophies have a highly heterogeneous genetic background linked mainly to mutations in oligodendrocyte and astrocyte gen...
Jianqin Niu,Alexei Verkhratsky,Arthur Butt et al.
Jianqin Niu et al.
Myelinating oligodendrocytes and oligodendrocyte precursor cells (OPCs) make up half the cells in the central nervous system and are affected by and contribute to all neurological diseases. The pathology of myelinating oligodendrocytes is f...
Plasticity of Myelination [0.03%]
髓鞘的可塑性
Grace Flower,Svenja Vorthmann,Daniel Fulton et al.
Grace Flower et al.
Myelin plasticity, the capacity for dynamic changes in myelination and myelin structure, challenges the long-held view of myelin as a static entity post-development. Emerging evidence highlights its pivotal role in adapting neural circuits ...
Qi Han,Jin Cheng
Qi Han
Oligodendrocytes (OLs) exhibit complex metabolic interactions essential for neuronal function and CNS health. This chapter analyzes the metabolism of OLs, particularly glucose, lipid, and amino acid metabolism, and their impact on myelin sy...
Arthur Butt,Adam Willis,Ian Hunter et al.
Arthur Butt et al.
Oligodendroglia are highly specialised to myelinate axons and ensure rapid electrical conduction of action potentials in the central nervous system (CNS). The oligodendroglial cell lineage comprises mature myelinating oligodendrocytes, toge...
Arthur Butt,Adam Willis,Rachel Stevens et al.
Arthur Butt et al.
Oligodendrocytes are cells in the central nervous system that are specialised to form myelin sheaths around axons. They are generated from oligodendrocyte precursor cells that persist in the adult brain and are responsible for myelin plasti...
Seeing Is Believing: Insights into Myelination and Remyelination in Zebrafish [0.03%]
明察秋毫：斑马鱼髓鞘形成和再形成的见解
Peng Liu,Qiang Chen,Cheng He
Peng Liu
Myelin is the lipid-rich insulating layer that wraps axons, providing trophic support and ensuring rapid propagation of the electrical impulses that underlie nervous system function. In the CNS, myelin is produced by mature oligodendrocytes...
Hao Huang,Xiaofeng Xu,Mengsheng Qiu
Hao Huang
Myelin sheaths formed by oligodendrocytes (OLs) wrap around neuronal axons and allow for saltatory conduction of nerve impulses, significantly increasing the speed of electrical signal transmission. The development of oligodendrocyte lineag...