Christina Besada,Ole Valente Mortensen
Christina Besada
The dopamine transporter (DAT) is a plasma membrane protein expressed in dopamine (DA) neurons of the central nervous system and is critical for regulating DA neurotransmission. The DAT is responsible for the reuptake of released DA back in...
Unlocking the Potential of High-Quality Dopamine Transporter Pharmacological Data: Advancing Robust Machine Learning-Based QSAR Modeling [0.03%]
释放高质量多巴胺 transporter 药理数据的潜力：推进稳健的机器学习基于QSAR 模型
Kuo Hao Lee,Sung Joon Won,Precious Oyinloye et al.
Kuo Hao Lee et al.
The dopamine transporter (DAT) plays a critical role in the central nervous system and has been implicated in numerous psychiatric disorders. The ligand-based approaches are instrumental to decipher the structure-activity relationship (SAR)...
Substrate Binding and Conformational Dynamics of the Monoamine Transporters [0.03%]
单胺转运蛋白的底物结合及其构象动力学
Jeppe C Nielsen,Claus J Loland
Jeppe C Nielsen
The monoamine transporters move substrates across the plasma membrane by an alternating-access mechanism, in which a central substrate-binding site is alternately exposed to either the extracellular milieu or the cytoplasm at any given time...
Pharmacological Mechanisms of SLC6 Neurotransmitter Transporter Inhibition [0.03%]
SLC6神经递质转运体抑制的药理机制
Dipanjana Bandyopadhyay,Smruti Ranjan Nayak,Aravind Penmatsa
Dipanjana Bandyopadhyay
Solute carrier 6 family members comprise of neurotransmitter sodium symporters that are the transporters primarily involved in the reuptake of released neurotransmitters from the synaptic space. The family includes structurally related tran...
Gating of Neuroplasticity: Effects and Mechanisms of Acute Aerobic Exercise as a Brain Stimulation for the Sensorimotor Cortex [0.03%]
急性有氧运动作为感觉运动皮层脑刺激的作用和机制：神经可塑性开启的影响和机制
Yudai Yamazaki,Daisuke Sato,Koya Yamashiro
Yudai Yamazaki
Aerobic exercise works as a "brain stimulation" or "medicine" to improve executive function, memory, and mental health. In addition to this evidence, recent studies have demonstrated that aerobic exercise positively affects neuroplasticity ...
Healthy Cognitive Aging Through Movement: A Practical Approach of Light-Intensity Aerobic Dance for Older Adults [0.03%]
动中求智——适合老年人的低强度有氧舞蹈认知训练项目之实践探索
Kazuki Hyodo,Hideaki Soya
Kazuki Hyodo
Cognitive decline is a natural part of aging, though its progression varies significantly among individuals. There is a great deal of evidence showing that exercise is one of the most promising lifestyle factors that can both improve cognit...
Genta Ochi,Yuhki Yamada,Hideaki Soya
Genta Ochi
While moderate exercise has been demonstrated to enhance executive function, this beneficial effect may vary depending on the exercise environment. For instance, the decline in blood oxygen levels (hypoxemia) associated with ascent to high ...
Enriched Exercise Environment Boosting Exercise Effects on the Brain: Beneficial Effects of Music [0.03%]
富集运动环境增强运动对大脑的影响：音乐的积极作用
Kazuya Suwabe,Takemune Fukuie,Hideaki Soya
Kazuya Suwabe
Physical exercise is a potential medicine for cognitive function and mental health; however, regular exercise is more difficult than taking a pill every day. Developing an exercise environment that promotes a positive affective response to ...
Min-Chul Lee,Hideaki Soya
Min-Chul Lee
The importance of physical activity in neuroscience is gaining increasing recognition. The question arises: What is the specific focus of exercise, and what factors contribute to the observed benefits of exercise in neuroscience? Various fo...
Jang Soo Yook,Hideaki Soya
Jang Soo Yook
Oxidative stress in the brain is associated with the development and progression of neurological disorders, posing antioxidant nutrients as an effective strategy for protecting neuronal cells and potentially slowing cognitive decline. Bioac...