Axel T Brunger,Richard G Held,Yousuf A Khan et al.
Axel T Brunger et al.
Synaptic transmission between pre- and postsynaptic neurons occurs when the presynaptic neuron terminal is temporarily depolarized upon action potential arrival, opening voltage-gated Ca2+ channels at synapses. Ca2+ will flow into the presy...
Nano-organization of the Synapse: A Requisite Framework for Synaptic Signaling [0.03%]
纳米化突触组织：突触信号传导所需的基本框架
Ege T Kavalali
Ege T Kavalali
Synapses are the fundamental units of communication and information processing in the nervous system. They show remarkable functional autonomy, as well as speed of signaling, bidirectional plasticity, and diversity. Synapses shape complex n...
Monoamine-Uptake Inhibitors and Pain: Antidepressant Drugs Among First-Line Treatments Against Neuropathic Pain and Fibromyalgia [0.03%]
单胺再摄取抑制剂与镇痛：抗抑郁药是神经病理性疼痛和纤维肌痛症一线治疗药物之一
Michel Barrot,Henrico-Pio Basile,Mélanie Kremer
Michel Barrot
Some monoamine-uptake inhibitors are among first-line treatments for specific chronic pain conditions. It concerns tricyclic antidepressant drugs, such as amitriptyline or nortriptyline, and the more selective serotonergic and noradrenergic...
Yibin Xu,Hanming Zeng,Shaili Aggarwal et al.
Yibin Xu et al.
Dopamine (DA) is an important modulatory neurotransmitter that is involved in daily activities such as movement, memory, and reward-oriented learning of essential behaviors and needs. DA signaling is initiated by the release of DA into the ...
The Ins and Outs of Dopamine Transporter Gene Manipulation: In Vivo Models of DAT Dysfunction [0.03%]
多巴胺转运蛋白基因操作的幕后：DAT功能障碍的体内模型
Adele Stewart,Randy D Blakely
Adele Stewart
The clinical efficacy of psychostimulant drugs, which target monoamine transporters, in treating attention-deficit/hyperactivity disorders (ADHDs) has stimulated interest on the role of transporter proteins like the dopamine (DA) transporte...
Drosophila as an Animal Model To Determine the Functional and Behavioral Significance of Dopamine Transporter Genetic Variations Associated with Brain Disorders [0.03%]
拟南芥作为模式动物确定多巴胺转运蛋白遗传变异与大脑疾病的功能和行为的关系
Samuel J Mabry,Angela M Carter,Aurelio Galli
Samuel J Mabry
Drosophila melanogaster, commonly referred to as the "fruit fly," has been a long-utilized animal model in multiple areas of biological research. It is estimated that 75% of human genes, which are associated with disease, have homologues in...
Annalisa Scimemi
Annalisa Scimemi
Some neuronal populations in the brain have the ability to release multiple neurotransmitters, which may be packaged in the same vesicle, or released by distinct subsets of vesicles. Here, we review current knowledge on the molecular mechan...
Monoamine Transporters in Drugs of Abuse: Insights from Fast Scan Cyclic Voltammetry [0.03%]
快速扫描循环伏安法在药物滥用单胺转运蛋白中的应用及启示
Shanna B Samels,Pelin Yuksel,Rodrigo A España
Shanna B Samels
Monoamine transmission is critical for regulating numerous physiological processes, including stress, learning, motor activity, and reward. Over the past few decades, the adoption of fast scan cyclic voltammetry has unveiled an intricate in...
Electrophysiological Methods to Explore the Function of Monoamine Transporters [0.03%]
电生理学方法探索单胺转运体功能
Danila Boytsov,Michael Freissmuth,Walter Sandtner
Danila Boytsov
In this chapter we will show how electrophysiological recordings were used to gain insights into the transport kinetics and pharmacology of monoamine transporters (MATs). We will discuss data obtained from whole cell patch clamp recordings ...
Sammanda Ramamoorthy,Durairaj Ragu Varman,Lankupalle D Jayanthi
Sammanda Ramamoorthy
Monoamine transporters are essential proteins located at presynaptic terminals that play a crucial role in regulating neurotransmission of serotonin, dopamine, and norepinephrine by rapid reuptake of released amines from the synapse. Clinic...