Henry H C Lee,Mustafa Sahin
Henry H C Lee
Advances in molecular biology and genetics are increasingly revealing the complex etiology of autism spectrum disorder (ASD). In parallel, a number of biochemical, anatomical, and electrophysiological measures are emerging as potential dise...
Modern Methods for Unraveling Cell- and Circuit-Level Mechanisms of Neurophysiological Biomarkers in Psychiatry [0.03%]
揭秘精神病学神经生理生物标志物的细胞和环路机制的现代方法
A M Rader Groves,C G Gallimore,J P Hamm
A M Rader Groves
Methods for studying the mammalian brain in vivo have advanced dramatically in the past two decades. State-of-the-art optical and electrophysiological techniques allow direct recordings of the functional dynamics of thousands of neurons acr...
Magnetoencephalography in Psychiatry: A Perspective on Translational Research and Applications [0.03%]
脑电磁图在精神病学中的应用及转化研究展望
Angelantonio Tavella,Peter J Uhlhaas
Angelantonio Tavella
Magnetoencephalography (MEG) is a neuroimaging technique that has excellent temporal as well as good spatial resolution for measuring neural activity and has been extensively employed in cognitive neuroscience. However, MEG has only been mo...
Advanced Methodology for Neurophysiological Analysis and Biomarker Development: Time-Frequency and Source-Localization Approaches [0.03%]
高级神经生理分析和生物标志物开发方法学：时频和源定位法
Pejman Sehatpour,Daniel C Javitt
Pejman Sehatpour
The development of new treatments for neuropsychiatric disorders requires the development of physiological measures that can accurately translate between preclinical animal models and clinical human studies. Neurophysiological measures, esp...
Methods for and Use of Functional Magnetic Resonance Imaging in Psychiatry [0.03%]
精神病学中功能磁共振成像的方法及应用
Jessica K Lee,Andrew T Drysdale,A Benjamin Srivastava et al.
Jessica K Lee et al.
Functional magnetic resonance imaging (fMRI) is a noninvasive technique for measuring brain activity that uses MRI to measure the blood oxygen level dependent (BOLD) signal. Over the 30+ years since the technique was first described (Ogawa ...
Public-Private Partnerships for Neuropsychiatric Drug Development: A Perspective [0.03%]
神经精神药物开发的公私合作模式：一种观点
William Z Potter
William Z Potter
There is a long-standing interest in developing biomarkers for neuropsychiatric disorders that might assist in drug development or clinical management. To date, however, progress has been limited in part because of the limited nature of the...
Neural Circuitry-Related Biomarkers for Drug Development in Psychiatry: An Industry Perspective [0.03%]
神经环路相关生物标志物在精神病药物研发中的作用：工业界视角
Patricio O&#x;Donnell,Derek L Buhl,Jason Johannesen et al.
Patricio O&#x;Donnell et al.
Drug development in psychiatry has been hampered by the lack of reliable ways to determine the neurobiological effects of the assets tested, difficulties in identifying patient subsets more amenable to benefit from a given asset, and issues...
Margaret C Grabb,Linda S Brady
Margaret C Grabb
Biomarkers are critically important in the development of drugs, biologics, medical devices, and psychosocial interventions for psychiatric disorders. As the lead federal agency charged with setting and supporting the national agenda for me...
Age at Injury as a Modifier of Preclinical TBI Behavioral, Neuropathological, and Inflammatory Outcomes [0.03%]
受伤年龄作为修饰预临床TBI行为、神经病理和炎症结果的因素
Wai Hang Cheng,Mehwish Anwer,Jianjia Fan et al.
Wai Hang Cheng et al.
Traumatic brain injury (TBI) is a leading cause of injury-related death and disability. In high-income countries, TBI is most prevalent among the older population (≥65 years), commonly caused by falls. Though age at injury is associated wi...
The Neuroimmune Interface: Age-Related Responses to Traumatic Brain Injury [0.03%]
神经免疫界面：创伤性脑损伤的年龄相关反应
John Leonard,Liliana Ladner,Elizabeth A Harris et al.
John Leonard et al.
Traumatic Brain Injury (TBI) is a significant public health issue, with diverse consequences across the lifespan. This comprehensive review explores the complex interplay between age-related responses and the immune system following TBI. TB...