Glucagon and insulin prescribing trends and cost implications in Japan: a 10-year analysis using the National Database Open Data Japan [0.03%]
日本胰高血糖素和胰岛素处方趋势及成本影响的十年分析：利用国家数据库开放数据日本进行的研究
Tomoyuki Saito,Kazutoshi Fujibayashi,Hiroshi Ohtsu et al.
Tomoyuki Saito et al.
Introduction: In 2020, ready-to-use nasal glucagon was introduced in Japan, enabling more rapid caregiver response during episodes of severe hypoglycemia. However, nationwide prescribing patterns and changes in drug expen...
The combination of the D-dimer/fibrinogen ratio and the CHA2DS2-VA score is exploited for the prediction of carotid atherosclerosis in patients with type 2 diabetes mellitus: a retrospective cohort study [0.03%]
D-二聚体/纤维蛋白原比值与CHA2DS2-VA评分结合用于预测2型糖尿病患者颈动脉粥样硬化的队列研究
Shikai Wang,Zhenzhen Long,Junli Zhang et al.
Shikai Wang et al.
Background: The ratio of D-dimer to fibrinogen is intimately associated with the occurrence, progression, and severity of coronary artery lesions in atherosclerosis (Hou in Chin J Stroke 16:805-809, 2021; Alkhalfan in Am ...
RFX6 expression is central to the development and function of the neuroendocrine compartments of the pancreas and intestine and strongly affects diabetes risk [0.03%]
RFX6的表达是胰腺和肠道神经内分泌区室发育和功能的核心，对糖尿病风险具有重要影响
Thomas S R Bate,Yuanhao Huang,Xin Luo et al.
Thomas S R Bate et al.
Transcription factors are central to the developmental and functional regulation of cells through co-ordination of gene expression via interaction with the genome. RFX6 is a winged-helix transcription factor whose expression is highly speci...
Domenico Accili,Wen Du,Takumi Kitamoto et al.
Domenico Accili et al.
Diabetes is associated with β-cell destruction (Type 1) or functional failure (Type 2). Our research has shown that β-cell failure in Type 2 Diabetes is secondary to the progression of β-cell dedifferentiation. Until recently, it was unc...
Hypoglycemia problem-solving ability as a key predictor of severe hypoglycemia: a machine learning approach in adults with type 1 diabetes [0.03%]
低血糖问题解决能力是1型糖尿病成人严重低血糖的关键预测因素：一种机器学习方法
Naoki Sakane,Ken Kato,Sonyun Hata et al.
Naoki Sakane et al.
Aims/introduction: Severe hypoglycemia (SH) is a major complication in adults with type 1 diabetes mellitus (T1DM). The multifactorial etiology of T1DM highlights the need for predictive tools that integrate clinical, beh...
Impact of diabetes care discontinuation on healthcare costs in older patients with type 2 diabetes: a retrospective study using medical claims data [0.03%]
糖尿病治疗中断对2型糖尿病老年患者医疗费用的影响：一项基于医疗保险数据的回顾性研究
Akira Kurishima,Kenjiro Imai,Yusuke Kuwai et al.
Akira Kurishima et al.
Aim: Despite the increasing number of older patients with diabetes in Japan, few studies have examined the impact of care interruption on older patients. This study aimed to investigate care interruption in older patients...
Identification of severe hypoglycemia in adults with type 1 diabetes using CGM-based machine learning: evidence from the FGM-Japan study [0.03%]
基于CGM的机器学习在1型糖尿病成人患者中识别严重低血糖：来自日本FGM研究组的证据
Naoki Sakane,Yushi Hirota,Akane Yamamoto et al.
Naoki Sakane et al.
Background: Severe hypoglycemia (SH) in adults with type 1 diabetes mellitus (T1DM) is associated with significant morbidity and mortality; however, its underlying causes are often complex and multifactorial. Improved too...
Clinical utility of the MAF-5 score for assessing MAFLD/MASLD in a Japanese population with obesity [0.03%]
MAFLD/MASLD日本肥胖人群的临床实用性maf-5评分评估
Hayato Fukumitsu,Kazuhiko Sakaguchi,Marika Nishisaka et al.
Hayato Fukumitsu et al.
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) coexists with type 2 diabetes and is rising in Japan. Liver fibrosis progression in MASLD causes adverse outcomes, highlighting the need for ear...
Heart rate variability analysis using electrocardiograms during cardio-ankle vascular index measurement shows good agreement with resting electrocardiogram-based analysis in patients with diabetes: a retrospective cross-sectional study [0.03%]
基于心电图的糖尿病患者静息和踝部血压测量期间的心率变异性分析：回顾性横断面研究
Yuka Shibata,Toshiki Kiyose,Tatsuhito Himeno et al.
Yuka Shibata et al.
Background: Cardiovascular autonomic neuropathy (CAN) is a common but underrecognized diabetic complication. Although heart rate variability (HRV) analysis is a less invasive alternative to cardiovascular autonomic reflex...
Molecular mechanism for pancreatic β-cell dysfunction and atherosclerosis [0.03%]
胰岛β细胞功能紊乱和动脉粥样硬化病变的分子机制研究
Hideaki Kaneto
Hideaki Kaneto
It is well known in clinical practice that when pancreatic β-cells are chronically exposed to hyperglycemia, β-cell function is gradually deteriorated. It has been revealed that under diabetic conditions oxidative stress is provoked and e...