Generation and Propagation of MALDI Ion Packets Probed by Sheet-Like Nanosecond UV Laser Light [0.03%]
利用片状纳秒紫外线激光探测基质辅助激光解析离子包的产生及传输
Tatsuro Shirota,Kennosuke Hoshina
Tatsuro Shirota
A sheet-like ultraviolet (UV) probe laser is used to investigate the ejection and propagation of ion packets of matrix CHCA, which are produced by matrix-assisted laser desorption and ionization (MALDI). Laser irradiation of the expanding M...
OH-Radical Oxidation of Lung Surfactant Protein B on Aqueous Surfaces [0.03%]
溶剂表面上肺表面活性物质蛋白B的羟自由基氧化反应
Shinichi Enami,Agustín J Colussi
Shinichi Enami
Air pollutants generate reactive oxygen species on lung surfaces. Here we report how hydroxyl radicals (·OH) injected on the surface of water react with SP-B1-25, a 25-residue polypeptide surrogate of human lung surfactant protein B. Our e...
Shoichiro Yokota
Shoichiro Yokota
Isotope analyses using mass spectrometers have been frequently utilized in the laboratories for the earth planetary science and other scientific and industrial fields. In order to conduct in-situ measurements of compositions and isotope rat...
Distribution of Antisense Oligonucleotides in Rat Eyeballs Using MALDI Imaging Mass Spectrometry [0.03%]
基于矩阵辅助激光解析电离质谱的反义寡核苷酸在大鼠眼球内分布研究
Yuko Nakashima,Mitsutoshi Setou
Yuko Nakashima
Oligonucleotide-based therapeutics such as antisense oligonucleotides, small interfering RNAs (siRNAs), decoy and aptamer have been extensively developed. To investigate the pharmacokinetics of oligonucleotide therapeutics, it is common to ...
Development of a Vacuum Electrospray Droplet Ion Gun for Secondary Ion Mass Spectrometry [0.03%]
用于二次离子质谱的电喷雾离子枪的发展
Satoshi Ninomiya,Yuji Sakai,Lee Chuin Chen et al.
Satoshi Ninomiya et al.
Atmospheric pressure electrospray had been used in previous studies to generate massive water droplet ion beams, and the beams successfully achieved efficient desorption/ionization of biomolecules, low damage etching of polymers and nonsele...
Mass Spectrometry-Inspired Degradation of Disinfection By-Product, 2,6-Dichloro-1,4-benzoquinone, in Drinking Water by Heating [0.03%]
加热引发的饮用水中消毒副产物2,6-二氯苯醌降解：质谱学启示
Jiying Pei,Ruiling Zhang,Chengchih Hsu et al.
Jiying Pei et al.
2,6-Dichloro-1,4-benzoquinone (DCBQ), a highly toxic and carcinogenic disinfection by-product, was degraded during the electrospray process by elevating the source temperature. This unexpected finding inspired us to use heating to degrade D...
Mass Spectrometry-Based Method to Study Inhibitor-Induced Metabolic Redirection in the Central Metabolism of Cancer Cells [0.03%]
基于质谱的癌细胞中心代谢途径代谢重组研究方法学建立及应用
Chie Araki,Nobuyuki Okahashi,Kousuke Maeda et al.
Chie Araki et al.
Cancer cells often respond to chemotherapeutic inhibitors by redirecting carbon flow in the central metabolism. To understand the metabolic redirections of inhibitor treatment on cancer cells, this study established a 13C-metabolic flux ana...
Physicochemical Prediction of Metabolite Fragmentation in Tandem Mass Spectrometry [0.03%]
基于物理化学预测代谢产物在串联质谱中的碎裂规律
Wataru Tanaka,Masanori Arita
Wataru Tanaka
Current bottleneck of comprehensive non-target metabolite identification is insufficient spectral library. Many research groups have tried to build a theoretical product ion spectral library independent of measurement condition or settings,...
iQuant2: Software for Rapid and Quantitative Imaging Using Laser Ablation-ICP Mass Spectrometry [0.03%]
iQuant2：基于激光剥蚀等离子体质谱的快速定量影像分析软件
Toshihiro Suzuki,Shuhei Sakata,Yoshiki Makino et al.
Toshihiro Suzuki et al.
We report on the development of a software program named iQuant2 which creates visual images from two-dimensional signal intensity data obtained by a laser ablation-ICP-mass spectrometry (LA-ICPMS) technique. Time-resolved signal intensity ...
pH Dependence of the Number of Discrete Conformers of Carbonic Anhydrase 2, as Evaluated from Collision Cross-Section Using Ion Mobility Coupled with Electrospray Ionization [0.03%]
基于电喷雾电离与离子淌度耦合的碰撞截面积计算得出的溶质酸2在不同pH条件下的构象异构体数目及其分布规律
Yoshiaki Nabuchi,Kenji Hirose,Mitsuo Takayama
Yoshiaki Nabuchi
Ion mobility experiments coupled with electrospray ionization (ESI) were conducted to evaluate the folding states of bovine carbonic anhydrase 2 (CA2) under three different pH conditions. Collision cross-section (CCS) of the CA2 ions genera...