Electrospray Ionization Mass Spectrometry of Transferrin: Use of Quadrupole Mass Analyzers for Congenital Disorders of Glycosylation [0.03%]
应用四极质量分析器对转铁蛋白进行电喷雾离子化质谱分析研究糖蛋白先天性代谢缺陷疾病
Yoshinao Wada,Nobuhiko Okamoto
Yoshinao Wada
Electrospray ionization (ESI) mass spectrometry of transferrin can be used to diagnose congenital disorders of glycosylation (CDG) by detecting abnormal N-glycosylation due to reduced site occupancy or processing failure. Time-of-flight mas...
Electrospray Ionization Mass Spectrometry of Apolipoprotein CIII to Evaluate O-glycan Site Occupancy and Sialylation in Congenital Disorders of Glycosylation [0.03%]
用于评估先天性糖基化障碍中O-聚糖位点占有率和唾液酸化的载脂蛋白CIII的电喷雾离子化质谱分析
Yoshinao Wada,Nobuhiko Okamoto
Yoshinao Wada
Congenital disorders of glycosylation (CDG) are inherited metabolic diseases that affect the synthesis of glycoconjugates. Defects in mucin-type O-glycosylation occur independently or in combination with N-glycosylation disorders, and the p...
Fragmentation and Ionization Efficiency of Positional and Functional Isomers of Paeoniflorin Derivatives in Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry [0.03%]
基质辅助激光解吸/离子化飞行时间质谱中芍药苷衍生物位置异构体和功能异构体的碎片离子化效率研究
Tohru Yamagaki,Kohtaro Sugahara,Kohki Fujikawa et al.
Tohru Yamagaki et al.
Paeoniflorin and albiflorin, which are functional isomers, are the major constituents of an herbal medicine derived from Paeonia lactiflora. Those functional isomers and their galloylated derivatives, which are positional isomers, were stud...
Shuichi Shimma
Shuichi Shimma
Mass spectrometry imaging (MSI) is a technique for obtaining information on the distribution of various molecules by performing mass spectrometry directly on the sample surface. The applications range from small molecules such as lipids to ...
Corona Discharge and Field Electron Emission in Ambient Air Using a Sharp Metal Needle: Formation and Reactivity of CO3 -• and O2 -• [0.03%]
使用尖金属针在环境空气中产生冠放电和场致电子发射：CO3 -• 和O2 -•的形成及反应性
Kenzo Hiraoka,Stephanie Rankin-Turner,Satoshi Ninomiya et al.
Kenzo Hiraoka et al.
CO3 -• and O2 -• are known to be strong oxidizing reagents in biological systems. CO3 -• in particular can cause serious damage to DNA and proteins by H• abstraction reactions. However, H• abstraction of CO3 -• in the gas phase has no...
Improvement in Ionization Efficiency Using Metal Oxide Nanoparticles in Laser Desorption/Ionization Mass Spectrometry of a Cancer Drug [0.03%]
金属氧化物纳米颗粒在激光解吸电离质谱癌症药物分析中的离子化效率研究
Hiroki Kannen,Yuto Miyoshi,Hisanao Hazama et al.
Hiroki Kannen et al.
Mass spectrometry imaging (MSI) without labeling has the potential for faster screening in drug development. Matrix-assisted laser desorption/ionization (MALDI) is typically used, but it has a large matrix size and uneven drug distribution....
A Method for Expanding Mass Range on a Multi-Turn Time-of-Flight Mass Spectrometer by a Lap Superimposed Spectrum [0.03%]
多圈飞行时间质谱仪通过叠加拉普谱图扩展质量范围的方法
Toshinobu Hondo,Michisato Toyoda
Toshinobu Hondo
A time-of-flight mass spectrometer that uses a closed-orbit flight path can achieve a high mass resolving power and a high mass accuracy with a small instrument footprint. It has long been known that a drawback to a closed flight path is an...
Quantification of Amino Acid Enantiomers Using Electrospray Ionization and Ultraviolet Photodissociation [0.03%]
用电喷雾电离和紫外光解离定量氨基酸对映体
Kanako Inoue,Akimasa Fujihara
Kanako Inoue
The enantioselectivity of tryptophan (Trp) for amino acids, such as alanine (Ala), valine (Val), and serine (Ser), was investigated using ultraviolet (UV) photoexcitation and tandem mass spectrometry. Product ion spectra of cold gas-phase a...
Direct Liquid Extraction and Ionization Techniques for Understanding Multimolecular Environments in Biological Systems (Secondary Publication) [0.03%]
用于理解生物系统中多分子环境的直接液体提取和离子化技术
Yoichi Otsuka
Yoichi Otsuka
A combination of direct liquid extraction using a small volume of solvent and electrospray ionization allows the rapid measurement of complex chemical components in biological samples and visualization of their distribution in tissue sectio...
Gas-Phase Adsorption of N2 on Protonated Molecules and Its Application to the Structural Elucidation of Small Molecules [0.03%]
氮气在质子化分子上的气相吸附及其在小分子结构解析中的应用
Hiromori Murashima,Akimasa Fujihara
Hiromori Murashima
The gas-phase adsorption of N2 on protonated serine (Ser, C3H7NO3), threonine (Thr, C4H9NO3), glycine (Gly, C2H5NO2), and 2-aminoethanol (C2H7NO) was investigated using a tandem mass spectrometer equipped with an electrospray ionization sou...